Summary: This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014].

Fas ligandMIM:134638Ensembl:ENSG00000117560HGNC:HGNC:11936PA561q24.3

GO terms in FASLG

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005102signaling receptor binding
MFIEAGO:0005123death receptor binding
MFIEAGO:0005125cytokine activity
MFIEAGO:0005164tumor necrosis factor receptor binding
MFIPIGO:0005515protein binding
CCTASGO:0005576extracellular region
CCIDAGO:0005615extracellular space
CCIDAGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIEAGO:0009897external side of plasma membrane
CCIEAGO:0043202lysosomal lumen
CCIEAGO:0048471perinuclear region of cytoplasm
CCIEAGO:0060205cytoplasmic vesicle lumen
CCIDAGO:0070062extracellular exosome
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006351transcription, DNA-templated
BPTASGO:0006915apoptotic process
BPIGIGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPIMPGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPTASGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPIEAGO:0006925inflammatory cell apoptotic process
BPIEAGO:0006955immune response
BPTASGO:0007165signal transduction
BPTASGO:0007267cell-cell signaling
BPIEAGO:0008284positive regulation of cell proliferation
BPIDAGO:0008625extrinsic apoptotic signaling pathway via death domain receptors
BPIEAGO:0010469regulation of signaling receptor activity
BPIDAGO:0016525negative regulation of angiogenesis
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0030644cellular chloride ion homeostasis
BPIEAGO:0032496response to lipopolysaccharide
BPIDAGO:0043065positive regulation of apoptotic process
BPIEPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0043525positive regulation of neuron apoptotic process
BPIEAGO:0045742positive regulation of epidermal growth factor receptor signaling pathway
BPIEAGO:0046666retinal cell programmed cell death
BPIEAGO:0048388endosomal lumen acidification
BPIDAGO:0070231T cell apoptotic process
BPIDAGO:0070266necroptotic process
BPIEAGO:0070848response to growth factor
BPIDAGO:0097190apoptotic signaling pathway
BPTASGO:0097190apoptotic signaling pathway
BPIDAGO:0097191extrinsic apoptotic signaling pathway
BPIDAGO:0097527necroptotic signaling pathway
BPTASGO:1902041regulation of extrinsic apoptotic signaling pathway via death domain receptors
BPTASGO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
BPIDAGO:1903514release of sequestered calcium ion into cytosol by endoplasmic reticulum
BPIDAGO:2000353positive regulation of endothelial cell apoptotic process

Gene expression in normal tissue: FASLG

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FASLG

DatabasePathway IDPathway Des.
biocartaachpathwayrole of nicotinic acetylcholine receptors in the regulation of apoptosis
biocartaaktpathwayakt signaling pathway
biocartafaspathwayfas signaling pathway (cd95)
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartahsp27pathwaystress induction of hsp regulation
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartakeratinocytepathwaykeratinocyte differentiation
biocartaptenpathwaypten dependent cell cycle arrest and apoptosis
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-140534via Death Receptors in the presence of ligand
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168256Immune System
reactomeR-HSA-3371378Regulation by c-FLIP
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-5213460RIPK1-mediated regulated necrosis
reactomeR-HSA-5218859Regulated Necrosis
reactomeR-HSA-5218900CASP8 activity is inhibited
reactomeR-HSA-5357769Caspase activation via extrinsic apoptotic signalling pathway
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5668541TNFR2 non-canonical NF-kB pathway
reactomeR-HSA-5669034TNFs bind their physiological receptors
reactomeR-HSA-5675482Regulation of necroptotic cell death
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-69416Dimerization of procaspase-8
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-75157FasL/ CD95L signaling
reactomeR-HSA-8862803Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
reactomeR-HSA-8863678Neurodegenerative Diseases
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP2507Nanomaterial induced apoptosis
wikipathwaysWP314Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP384Apoptosis Modulation by HSP70
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP4115Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer,s disease models
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling
wikipathwaysWP710DNA Damage Response (only ATM dependent)
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa04940Type I diabetes mellitus - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05143African trypanosomiasis - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05320Autoimmune thyroid disease - Homo sapiens (human)
kegghsa05330Allograft rejection - Homo sapiens (human)
kegghsa05332Graft-versus-host disease - Homo sapiens (human)
pidcaspase_pathwayCaspase Cascade in Apoptosis
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidfaspathwayFAS (CD95) signaling pathway
pidfoxopathwayFoxO family signaling
pidhivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
pidil12_2pathwayIL12-mediated signaling events
pidil2_stat5pathwayIL2 signaling events mediated by STAT5
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
pidtcrcalciumpathwayCalcium signaling in the CD4+ TCR pathway

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FASLG