FASLG
Summary: This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Fas ligand | MIM:134638 | Ensembl:ENSG00000117560 | HGNC:HGNC:11936 | PA56 | 1q24.3 |
GO terms in FASLG
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IEA | GO:0005123 | death receptor binding |
| MF | IEA | GO:0005125 | cytokine activity |
| MF | IEA | GO:0005164 | tumor necrosis factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0005901 | caveola |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | IEA | GO:0043202 | lysosomal lumen |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IEA | GO:0060205 | cytoplasmic vesicle lumen |
| CC | IDA | GO:0070062 | extracellular exosome |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IGI | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IMP | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0006925 | inflammatory cell apoptotic process |
| BP | IEA | GO:0006955 | immune response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IDA | GO:0016525 | negative regulation of angiogenesis |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0030644 | cellular chloride ion homeostasis |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0043525 | positive regulation of neuron apoptotic process |
| BP | IEA | GO:0045742 | positive regulation of epidermal growth factor receptor signaling pathway |
| BP | IEA | GO:0046666 | retinal cell programmed cell death |
| BP | IEA | GO:0048388 | endosomal lumen acidification |
| BP | IDA | GO:0070231 | T cell apoptotic process |
| BP | IDA | GO:0070266 | necroptotic process |
| BP | IEA | GO:0070848 | response to growth factor |
| BP | IDA | GO:0097190 | apoptotic signaling pathway |
| BP | TAS | GO:0097190 | apoptotic signaling pathway |
| BP | IDA | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | IDA | GO:0097527 | necroptotic signaling pathway |
| BP | TAS | GO:1902041 | regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | TAS | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IDA | GO:1903514 | release of sequestered calcium ion into cytosol by endoplasmic reticulum |
| BP | IDA | GO:2000353 | positive regulation of endothelial cell apoptotic process |
Gene expression in normal tissue: FASLG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FASLG
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | achpathway | role of nicotinic acetylcholine receptors in the regulation of apoptosis |
| biocarta | aktpathway | akt signaling pathway |
| biocarta | faspathway | fas signaling pathway (cd95) |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | hsp27pathway | stress induction of hsp regulation |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | ptenpathway | pten dependent cell cycle arrest and apoptosis |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-140534 | via Death Receptors in the presence of ligand |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-3371378 | Regulation by c-FLIP |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5213460 | RIPK1-mediated regulated necrosis |
| reactome | R-HSA-5218859 | Regulated Necrosis |
| reactome | R-HSA-5218900 | CASP8 activity is inhibited |
| reactome | R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5669034 | TNFs bind their physiological receptors |
| reactome | R-HSA-5675482 | Regulation of necroptotic cell death |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-69416 | Dimerization of procaspase-8 |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75157 | FasL/ CD95L signaling |
| reactome | R-HSA-8862803 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| reactome | R-HSA-8863678 | Neurodegenerative Diseases |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP2507 | Nanomaterial induced apoptosis |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP384 | Apoptosis Modulation by HSP70 |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4115 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer,s disease models |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa04940 | Type I diabetes mellitus - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05143 | African trypanosomiasis - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05320 | Autoimmune thyroid disease - Homo sapiens (human) |
| kegg | hsa05330 | Allograft rejection - Homo sapiens (human) |
| kegg | hsa05332 | Graft-versus-host disease - Homo sapiens (human) |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | cd8tcrdownstreampathway | Downstream signaling in naïve CD8+ T cells |
| pid | faspathway | FAS (CD95) signaling pathway |
| pid | foxopathway | FoxO family signaling |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | il2_stat5pathway | IL2 signaling events mediated by STAT5 |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| pid | tcrcalciumpathway | Calcium signaling in the CD4+ TCR pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FASLG
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.