FASLG
Summary: This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
NameFas ligand OMIM IDMIM:134638 Ensembl IDEnsembl:ENSG00000117560 HGNC IDHGNC:HGNC:11936 PHARMGKB IDPA56 Map Location1q24.3 | |||||
GO terms in FASLG
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IEA | GO:0005123 | death receptor binding |
| MF | IEA | GO:0005125 | cytokine activity |
| MF | IEA | GO:0005164 | tumor necrosis factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| CC | TAS | GO:0005576 | extracellular region |
Gene expression in normal tissue: FASLG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FASLG
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | achpathway | role of nicotinic acetylcholine receptors in the regulation of apoptosis |
| biocarta | aktpathway | akt signaling pathway |
| biocarta | faspathway | fas signaling pathway (cd95) |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | hsp27pathway | stress induction of hsp regulation |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FASLG
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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