FASLG


Summary: This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:134638
PHARMGKB IDPA56
Map Location1q24.3

GO terms in FASLG


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0005102 signaling receptor binding
MF IEA GO:0005123 death receptor binding
MF IEA GO:0005125 cytokine activity
MF IEA GO:0005164 tumor necrosis factor receptor binding
MF IPI GO:0005515 protein binding
CC TAS GO:0005576 extracellular region
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Gene expression in normal tissue: FASLG

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 18LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3

Gene-drug pathway distribution

undefined5Apoptosis regulation1p53 pathway1

Pathways in FASLG


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Database
Pathway ID
Pathway Des.
biocarta achpathway role of nicotinic acetylcholine receptors in the regulation of apoptosis
biocarta aktpathway akt signaling pathway
biocarta faspathway fas signaling pathway (cd95)
biocarta hivnefpathway hiv-1 nef: negative effector of fas and tnf
biocarta hsp27pathway stress induction of hsp regulation
biocarta il2rbpathway il-2 receptor beta chain in t cell activation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD187 BRD9876 3
iGMDRD451 Serdemetan 3
iGMDRD318 PAC-1 3
iGMDRD474 Avrainvillamide 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FASLG

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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