NAV3
Summary: This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| neuron navigator 3 | MIM:611629 | Ensembl:ENSG00000067798 | HGNC:HGNC:15998 | PA31453 | 12q21.2 |
GO terms in NAV3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0008017 | microtubule binding |
| CC | IEA | GO:0005640 | nuclear outer membrane |
| CC | IMP | GO:1990752 | microtubule end |
| BP | IMP | GO:0007026 | negative regulation of microtubule depolymerization |
| BP | IBA | GO:0007399 | nervous system development |
| BP | IMP | GO:0030336 | negative regulation of cell migration |
| BP | IMP | GO:0031116 | positive regulation of microtubule polymerization |
| BP | IMP | GO:0032703 | negative regulation of interleukin-2 production |
| BP | IMP | GO:1905929 | positive regulation of invadopodium disassembly |
Gene expression in normal tissue: NAV3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NAV3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2880 | Glucocorticoid Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD251 | ML162 | 4 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD705 | Nakiterpiosin | 4 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD662 | JQ-1 | 1 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD42 | Vorinostat | 4 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD148 | Pifithrin-mu | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD698 | Neratinib | 8 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 4 |
| iGMDRD138 | PX 12 | 6 |
| iGMDRD474 | Avrainvillamide | 9 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD885 | Compound 110 | 1 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD866 | BRD1812 | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD670 | ML 210 | 1 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD71 | Sparfosic acid | 1 |
| iGMDRD797 | ISOX DUAL | 1 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD394 | BX-795 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NAV3
CLASSFICATION
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