INSRR
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| insulin receptor related receptor | MIM:147671 | Ensembl:ENSG00000027644 | HGNC:HGNC:6093 | PA29899 | 1q23.1 |
GO terms in INSRR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | NAS | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030238 | male sex determination |
| BP | IDA | GO:0031532 | actin cytoskeleton reorganization |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IBA | GO:0042593 | glucose homeostasis |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0046777 | protein autophosphorylation |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0071469 | cellular response to alkaline pH |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | NAS | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0005899 | insulin receptor complex |
| CC | IBA | GO:0030424 | axon |
| CC | IBA | GO:0043235 | receptor complex |
| CC | IDA | GO:0043235 | receptor complex |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IDA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | NAS | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IBA | GO:0005009 | insulin-activated receptor activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IEA | GO:0043548 | phosphatidylinositol 3-kinase binding |
| MF | IBA | GO:0043560 | insulin receptor substrate binding |
| MF | IEA | GO:0043560 | insulin receptor substrate binding |
Gene expression in normal tissue: INSRR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in INSRR
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD484 | Pluripotin | 5 |
| iGMDRD150 | RITA | 1 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD634 | SCHEMBL2608041 | 6 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD446 | LY 2183240 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in INSRR
CLASSFICATION
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.