BMI1
Summary: This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BMI1 proto-oncogene, polycomb ring finger | MIM:164831 | Ensembl:ENSG00000168283 | HGNC:HGNC:1066 | PA25376 | 10p12.2 |
Gene Categories:
HISTONE MODIFICATIONGO terms in BMI1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0071535 | RING-like zinc finger domain binding |
| MF | IBA | GO:1990841 | promoter-specific chromatin binding |
| MF | IDA | GO:1990841 | promoter-specific chromatin binding |
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0006342 | chromatin silencing |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0007379 | segment specification |
| BP | IMP | GO:0010468 | regulation of gene expression |
| BP | IEP | GO:0030097 | hemopoiesis |
| BP | IBA | GO:0036353 | histone H2A-K119 monoubiquitination |
| BP | IMP | GO:0036353 | histone H2A-K119 monoubiquitination |
| BP | IMP | GO:0045814 | negative regulation of gene expression, epigenetic |
| BP | IMP | GO:0048146 | positive regulation of fibroblast proliferation |
| BP | IDA | GO:0051443 | positive regulation of ubiquitin-protein transferase activity |
| BP | TAS | GO:0070317 | negative regulation of G0 to G1 transition |
| CC | IDA | GO:0000151 | ubiquitin ligase complex |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IDA | GO:0031519 | PcG protein complex |
| CC | IBA | GO:0035102 | PRC1 complex |
| CC | IDA | GO:0035102 | PRC1 complex |
Gene expression in normal tissue: BMI1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BMI1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| biocarta | prc2pathway | the prc2 complex sets long-term gene silencing through modification of histone tails |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108214 | SUMOylation of DNA damage response and repair proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3899300 | SUMOylation of transcription cofactors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4551638 | SUMOylation of chromatin organization proteins |
| reactome | R-HSA-4570464 | SUMOylation of RNA binding proteins |
| reactome | R-HSA-4655427 | SUMOylation of DNA methylation proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8953750 | Transcriptional Regulation by E2F6 |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD6 | AM-580 | 6 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD82 | Quiflapon | 4 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD60 | Quinoclamine | 9 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD871 | BRD6368 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BMI1
CLASSFICATION
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