BMI1
Summary: This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:164831 Ensembl IDEnsembl:ENSG00000168283 HGNC IDHGNC:HGNC:1066 PHARMGKB IDPA25376 Map Location10p12.2 | |||||
Gene Categories:
HISTONE MODIFICATIONGO terms in BMI1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0071535 | RING-like zinc finger domain binding |
| MF | IBA | GO:1990841 | promoter-specific chromatin binding |
| MF | IDA | GO:1990841 | promoter-specific chromatin binding |
| BP | IBA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
Gene expression in normal tissue: BMI1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BMI1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| biocarta | prc2pathway | the prc2 complex sets long-term gene silencing through modification of histone tails |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BMI1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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