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CSPP1

Summary: This gene encodes a centrosome and spindle pole associated protein. The encoded protein plays a role in cell-cycle progression and spindle organization, regulates cytokinesis, interacts with Nephrocystin 8 and is required for cilia formation. Mutations in this gene result in primary cilia abnormalities and classical Joubert syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
centrosome and spindle pole associated protein 1	MIM:611654	Ensembl:ENSG00000104218	HGNC:HGNC:26193	PA142672066	8q13.1-q13.2

Gene Categories:

TUMOR SUPPRESSOR

GO terms in CSPP1

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0032467	positive regulation of cytokinesis
BP	IMP	GO:0032467	positive regulation of cytokinesis
BP	IMP	GO:0051781	positive regulation of cell division
CC	IBA	GO:0000922	spindle pole
CC	IDA	GO:0000922	spindle pole
CC	IEA	GO:0005737	cytoplasm
CC	IBA	GO:0005813	centrosome
CC	IDA	GO:0005813	centrosome
CC	IDA	GO:0005819	spindle
CC	IEA	GO:0005874	microtubule

Gene expression in normal tissue: CSPP1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CSPP1

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD318	PAC-1	2
iGMDRD187	BRD9876	2
iGMDRD474	Avrainvillamide	2
iGMDRD268	Cerulenin	2
iGMDRD598	QS-11	3
iGMDRD188	Piperlongumine	4
iGMDRD887	Compound 23 citrate	2
iGMDRD577	BIX01294	3
iGMDRD562	Navitoclax	4
iGMDRD427	ABT737	2
iGMDRD483	SCH-529074	2
iGMDRD494	Neopeltolide	1
iGMDRD781	Sirolimus	2
iGMDRD599	Salermide	1
iGMDRD772	BRD4770	2
iGMDRD280	CYTOCHALASIN B	3
iGMDRD466	Chaetocin	2
iGMDRD446	LY 2183240	1
iGMDRD61	Kinetin riboside	1
iGMDRD6	AM-580	4
iGMDRD105	Triptolide	1
iGMDRD289	Parthenolide	4
iGMDRD192	CIL56	1
iGMDRD158	NSC141540	2
iGMDRD5	Tyrphostin AG 1478	2
iGMDRD552	AZD-1775	1
iGMDRD147	Prima-1	2
iGMDRD246	NPC26	2
iGMDRD414	MST-312	2
iGMDRD67	PENFLURIDOL	3
iGMDRD286	Nsc 632839	1
iGMDRD662	JQ-1	2
iGMDRD211	(1S,3R)-RSL3	2
iGMDRD945	ML214	2
iGMDRD85	Ursolic acid	4
iGMDRD237	ABT-751	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CSPP1

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.