CSPP1
Summary: This gene encodes a centrosome and spindle pole associated protein. The encoded protein plays a role in cell-cycle progression and spindle organization, regulates cytokinesis, interacts with Nephrocystin 8 and is required for cilia formation. Mutations in this gene result in primary cilia abnormalities and classical Joubert syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:611654 Ensembl IDEnsembl:ENSG00000104218 HGNC IDHGNC:HGNC:26193 PHARMGKB IDPA142672066 Map Location8q13.1-q13.2 | |||||
Gene Categories:
TUMOR SUPPRESSORGO terms in CSPP1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0032467 | positive regulation of cytokinesis |
| BP | IMP | GO:0032467 | positive regulation of cytokinesis |
| BP | IMP | GO:0051781 | positive regulation of cell division |
| CC | IBA | GO:0000922 | spindle pole |
| CC | IDA | GO:0000922 | spindle pole |
| CC | IEA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: CSPP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CSPP1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CSPP1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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