TWF2
Summary: The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| twinfilin actin binding protein 2 | MIM:607433 | Ensembl:ENSG00000247596 | HGNC:HGNC:9621 | PA162407429 | 3p21.2 |
GO terms in TWF2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0010591 | regulation of lamellipodium assembly |
| BP | IMP | GO:0010592 | positive regulation of lamellipodium assembly |
| BP | IBA | GO:0010976 | positive regulation of neuron projection development |
| BP | IMP | GO:0010976 | positive regulation of neuron projection development |
| BP | IEA | GO:0030030 | cell projection organization |
| BP | IBA | GO:0030042 | actin filament depolymerization |
| BP | ISS | GO:0030837 | negative regulation of actin filament polymerization |
| BP | IC | GO:0032532 | regulation of microvillus length |
| BP | IMP | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IBA | GO:0042989 | sequestering of actin monomers |
| BP | ISS | GO:0042989 | sequestering of actin monomers |
| BP | IMP | GO:0045773 | positive regulation of axon extension |
| BP | IBA | GO:0051016 | barbed-end actin filament capping |
| BP | ISS | GO:0051016 | barbed-end actin filament capping |
| BP | IMP | GO:0071300 | cellular response to retinoic acid |
| BP | IMP | GO:0071363 | cellular response to growth factor stimulus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | NAS | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005856 | cytoskeleton |
| CC | IBA | GO:0005884 | actin filament |
| CC | IBA | GO:0030016 | myofibril |
| CC | ISS | GO:0030016 | myofibril |
| CC | ISS | GO:0030027 | lamellipodium |
| CC | ISS | GO:0030175 | filopodium |
| CC | IDA | GO:0030426 | growth cone |
| CC | ISS | GO:0032420 | stereocilium |
| CC | ISS | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0003785 | actin monomer binding |
| MF | ISS | GO:0003785 | actin monomer binding |
| MF | IPI | GO:0005080 | protein kinase C binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | ISS | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IBA | GO:0051015 | actin filament binding |
Gene expression in normal tissue: TWF2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TWF2
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TWF2
CLASSFICATION
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