TWF2

Summary: The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nametwinfilin actin binding protein 2
OMIM IDMIM:607433
Ensembl IDEnsembl:ENSG00000247596
HGNC IDHGNC:HGNC:9621
PHARMGKB IDPA162407429
Map Location3p21.2

Gene Categories:

TYROSINE KINASEKINASE

GO terms in TWF2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0010591 regulation of lamellipodium assembly
BP IMP GO:0010592 positive regulation of lamellipodium assembly
BP IBA GO:0010976 positive regulation of neuron projection development
BP IMP GO:0010976 positive regulation of neuron projection development
BP IEA GO:0030030 cell projection organization
BP IBA GO:0030042 actin filament depolymerization
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Gene expression in normal tissue: TWF2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TWF2


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Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD505 Pevonedistat 3
iGMDRD399 Selumetinib 3
iGMDRD57 Chloropentafluorobenzene 3
iGMDRD780 PP-30 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TWF2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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