SPRY2
Summary: This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| sprouty RTK signaling antagonist 2 | MIM:602466 | Ensembl:ENSG00000136158 | HGNC:HGNC:11270 | PA36099 | 13q31.1 |
GO terms in SPRY2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | ISS | GO:0005634 | nucleus |
| CC | IBA | GO:0005829 | cytosol |
| CC | ISS | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0005856 | cytoskeleton |
| CC | IEA | GO:0005874 | microtubule |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0015630 | microtubule cytoskeleton |
| CC | ISS | GO:0016020 | membrane |
| CC | IEA | GO:0032587 | ruffle membrane |
| BP | IEA | GO:0000132 | establishment of mitotic spindle orientation |
| BP | IEA | GO:0007605 | sensory perception of sound |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | IDA | GO:0010801 | negative regulation of peptidyl-threonine phosphorylation |
| BP | IMP | GO:0016525 | negative regulation of angiogenesis |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | ISS | GO:0031345 | negative regulation of cell projection organization |
| BP | IMP | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IEA | GO:0034260 | negative regulation of GTPase activity |
| BP | IDA | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IBA | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway |
| BP | IEA | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway |
| BP | TAS | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| BP | IEA | GO:0042472 | inner ear morphogenesis |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043407 | negative regulation of MAP kinase activity |
| BP | IEA | GO:0043407 | negative regulation of MAP kinase activity |
| BP | IEA | GO:0045165 | cell fate commitment |
| BP | IEA | GO:0045595 | regulation of cell differentiation |
| BP | IBA | GO:0046580 | negative regulation of Ras protein signal transduction |
| BP | IEA | GO:0046580 | negative regulation of Ras protein signal transduction |
| BP | IBA | GO:0048513 | animal organ development |
| BP | IEA | GO:0051387 | negative regulation of neurotrophin TRK receptor signaling pathway |
| BP | IMP | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IEA | GO:0060437 | lung growth |
| BP | IEA | GO:0060449 | bud elongation involved in lung branching |
| BP | IDA | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| BP | ISS | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| BP | IDA | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IC | GO:0030291 | protein serine/threonine kinase inhibitor activity |
| MF | IMP | GO:0043539 | protein serine/threonine kinase activator activity |
Gene expression in normal tissue: SPRY2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SPRY2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| pid | erbb1_internalization_pathway | Internalization of ErbB1 |
| pid | fgf_pathway | FGF signaling pathway |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| netpath | Pathway_EGFR1 | EGFR1 |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| reactome | R-HSA-1295596 | Spry regulation of FGF signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-182971 | EGFR downregulation |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-5654726 | Negative regulation of FGFR1 signaling |
| reactome | R-HSA-5654727 | Negative regulation of FGFR2 signaling |
| reactome | R-HSA-5654732 | Negative regulation of FGFR3 signaling |
| reactome | R-HSA-5654733 | Negative regulation of FGFR4 signaling |
| reactome | R-HSA-5654736 | Signaling by FGFR1 |
| reactome | R-HSA-5654738 | Signaling by FGFR2 |
| reactome | R-HSA-5654741 | Signaling by FGFR3 |
| reactome | R-HSA-5654743 | Signaling by FGFR4 |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| biocarta | sprypathway | sprouty regulation of tyrosine kinase signals |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD474 | Avrainvillamide | 9 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD116 | CD437 | 5 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD536 | PLX-4720 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SPRY2
CLASSFICATION
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