SPRY2


Summary: This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
sprouty RTK signaling antagonist 2MIM:602466Ensembl:ENSG00000136158HGNC:HGNC:11270PA3609913q31.1

GO terms in SPRY2


Term TypeEvidence TypeGO Term IDGO Des.
CCISSGO:0005634nucleus
CCIBAGO:0005829cytosol
CCISSGO:0005829cytosol
CCTASGO:0005829cytosol
CCISSGO:0005856cytoskeleton
CCIEAGO:0005874microtubule
CCTASGO:0005886plasma membrane
CCIDAGO:0015630microtubule cytoskeleton
CCISSGO:0016020membrane
CCIEAGO:0032587ruffle membrane
BPIEAGO:0000132establishment of mitotic spindle orientation
BPIEAGO:0007605sensory perception of sound
BPIEAGO:0008285negative regulation of cell proliferation
BPIMPGO:0010628positive regulation of gene expression
BPIDAGO:0010801negative regulation of peptidyl-threonine phosphorylation
BPIMPGO:0016525negative regulation of angiogenesis
BPIMPGO:0030335positive regulation of cell migration
BPISSGO:0031345negative regulation of cell projection organization
BPIMPGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIEAGO:0034260negative regulation of GTPase activity
BPIDAGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIBAGO:0040037negative regulation of fibroblast growth factor receptor signaling pathway
BPIEAGO:0040037negative regulation of fibroblast growth factor receptor signaling pathway
BPTASGO:0042059negative regulation of epidermal growth factor receptor signaling pathway
BPIEAGO:0042472inner ear morphogenesis
BPIMPGO:0043066negative regulation of apoptotic process
BPIBAGO:0043407negative regulation of MAP kinase activity
BPIEAGO:0043407negative regulation of MAP kinase activity
BPIEAGO:0045165cell fate commitment
BPIEAGO:0045595regulation of cell differentiation
BPIBAGO:0046580negative regulation of Ras protein signal transduction
BPIEAGO:0046580negative regulation of Ras protein signal transduction
BPIBAGO:0048513animal organ development
BPIEAGO:0051387negative regulation of neurotrophin TRK receptor signaling pathway
BPIMPGO:0051897positive regulation of protein kinase B signaling
BPIEAGO:0060437lung growth
BPIEAGO:0060449bud elongation involved in lung branching
BPIDAGO:0070373negative regulation of ERK1 and ERK2 cascade
BPIMPGO:0070373negative regulation of ERK1 and ERK2 cascade
BPISSGO:0070373negative regulation of ERK1 and ERK2 cascade
BPIMPGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIEAGO:0071902positive regulation of protein serine/threonine kinase activity
BPIDAGO:1900747negative regulation of vascular endothelial growth factor signaling pathway
BPIEAGO:1990830cellular response to leukemia inhibitory factor
MFIPIGO:0005515protein binding
MFIPIGO:0019901protein kinase binding
MFICGO:0030291protein serine/threonine kinase inhibitor activity
MFIMPGO:0043539protein serine/threonine kinase activator activity

Gene expression in normal tissue: SPRY2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SPRY2


DatabasePathway IDPathway Des.
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
piderbb1_internalization_pathwayInternalization of ErbB1
pidfgf_pathwayFGF signaling pathway
pidptp1bpathwaySignaling events mediated by PTP1B
netpathPathway_EGFR1EGFR1
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2263Androgen Receptor Network in Prostate Cancer
wikipathwaysWP2858Ectoderm Differentiation
wikipathwaysWP437EGF-EGFR Signaling Pathway
reactomeR-HSA-1295596Spry regulation of FGF signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-177929Signaling by EGFR
reactomeR-HSA-182971EGFR downregulation
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-5654726Negative regulation of FGFR1 signaling
reactomeR-HSA-5654727Negative regulation of FGFR2 signaling
reactomeR-HSA-5654732Negative regulation of FGFR3 signaling
reactomeR-HSA-5654733Negative regulation of FGFR4 signaling
reactomeR-HSA-5654736Signaling by FGFR1
reactomeR-HSA-5654738Signaling by FGFR2
reactomeR-HSA-5654741Signaling by FGFR3
reactomeR-HSA-5654743Signaling by FGFR4
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
biocartasprypathwaysprouty regulation of tyrosine kinase signals

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD474Avrainvillamide9
iGMDRD267Oligomycin A2
iGMDRD872BRD71372
iGMDRD100Zebularine1
iGMDRD871BRD63683
iGMDRD188Piperlongumine6
iGMDRD398Sepantronium3
iGMDRD329Merck603
iGMDRD577BIX012946
iGMDRD147Prima-13
iGMDRD886Compound 1541A3
iGMDRD82Quiflapon3
iGMDRD353PD03259012
iGMDRD126Tipifarnib2
iGMDRD772BRD47703
iGMDRD427ABT7372
iGMDRD144NSC953976
iGMDRD116CD4375
iGMDRD781Sirolimus1
iGMDRD201SKI II3
iGMDRD536PLX-47202
iGMDRD280CYTOCHALASIN B6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SPRY2

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