SPRY2
Summary: This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602466 Ensembl IDEnsembl:ENSG00000136158 HGNC IDHGNC:HGNC:11270 PHARMGKB IDPA36099 Map Location13q31.1 | |||||
GO terms in SPRY2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | ISS | GO:0005634 | nucleus |
| CC | IBA | GO:0005829 | cytosol |
| CC | ISS | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | ISS | GO:0005856 | cytoskeleton |
| CC | IEA | GO:0005874 | microtubule |
Gene expression in normal tissue: SPRY2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SPRY2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| pid | erbb1_internalization_pathway | Internalization of ErbB1 |
| pid | fgf_pathway | FGF signaling pathway |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| netpath | Pathway_EGFR1 | EGFR1 |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SPRY2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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