CXCR4
Summary: This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| C-X-C motif chemokine receptor 4 | MIM:162643 | Ensembl:ENSG00000121966 | HGNC:HGNC:2561 | PA27058 | 2q22.1 |
GO terms in CXCR4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IDA | GO:0003779 | actin binding |
| MF | TAS | GO:0004930 | G-protein coupled receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0015026 | coreceptor activity |
| MF | IBA | GO:0016493 | C-C chemokine receptor activity |
| MF | NAS | GO:0016494 | C-X-C chemokine receptor activity |
| MF | IBA | GO:0019956 | chemokine binding |
| MF | IBA | GO:0019957 | C-C chemokine binding |
| MF | IPI | GO:0019957 | C-C chemokine binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IDA | GO:0032027 | myosin light chain binding |
| MF | IDA | GO:0043130 | ubiquitin binding |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005764 | lysosome |
| CC | IDA | GO:0005764 | lysosome |
| CC | IDA | GO:0005769 | early endosome |
| CC | IDA | GO:0005769 | early endosome |
| CC | IDA | GO:0005770 | late endosome |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0030054 | cell junction |
| CC | IDA | GO:0031252 | cell leading edge |
| CC | IDA | GO:0031410 | cytoplasmic vesicle |
| CC | IMP | GO:0032991 | protein-containing complex |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | IEP | GO:0001666 | response to hypoxia |
| BP | TAS | GO:0002407 | dendritic cell chemotaxis |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IBA | GO:0006935 | chemotaxis |
| BP | TAS | GO:0006954 | inflammatory response |
| BP | IBA | GO:0006955 | immune response |
| BP | IDA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | TAS | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IBA | GO:0007420 | brain development |
| BP | TAS | GO:0009615 | response to virus |
| BP | TAS | GO:0019064 | fusion of virus membrane with host plasma membrane |
| BP | IBA | GO:0019722 | calcium-mediated signaling |
| BP | IMP | GO:0019722 | calcium-mediated signaling |
| BP | IBA | GO:0022008 | neurogenesis |
| BP | TAS | GO:0030260 | entry into host cell |
| BP | ISS | GO:0043217 | myelin maintenance |
| BP | ISS | GO:0048714 | positive regulation of oligodendrocyte differentiation |
| BP | IMP | GO:0050920 | regulation of chemotaxis |
| BP | IBA | GO:0060326 | cell chemotaxis |
| BP | IEA | GO:0070098 | chemokine-mediated signaling pathway |
| BP | IDA | GO:0071345 | cellular response to cytokine stimulus |
Gene expression in normal tissue: CXCR4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CXCR4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | barrestinpathway | -arrestins in gpcr desensitization |
| biocarta | barrestinsrcpathway | roles of arrestin dependent recruitment of src kinases in gpcr signaling |
| biocarta | barrmapkpathway | role of -arrestins in the activation and targeting of map kinases |
| biocarta | ccr5pathway | pertussis toxin-insensitive ccr5 signaling in macrophage |
| biocarta | chrebppathway | chrebp regulation by carbohydrates and camp |
| biocarta | cskpathway | activation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor |
| biocarta | cxcr4pathway | cxcr4 signaling pathway |
| biocarta | gspathway | activation of camp-dependent protein kinase pka |
| biocarta | raccpathway | ion channels and their functional role in vascular endothelium |
| biocarta | vifpathway | hiv-1 defeats host-mediated resistance by cem15 |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162594 | Early Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-173107 | Binding and entry of HIV virion |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375276 | Peptide ligand-binding receptors |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
| reactome | R-HSA-380108 | Chemokine receptors bind chemokines |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-500792 | GPCR ligand binding |
| reactome | R-HSA-5663205 | Infectious disease |
| wikipathways | WP24 | Peptide GPCRs |
| wikipathways | WP2406 | Cardiac Progenitor Differentiation |
| wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
| wikipathways | WP3678 | Amplification and Expansion of Oncogenic Pathways as Metastatic Traits |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP455 | GPCRs, Class A Rhodopsin-like |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04672 | Intestinal immune network for IgA production - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | s1p_s1p3_pathway | S1P3 pathway |
| pid | syndecan_4_pathway | Syndecan-4-mediated signaling events |
| netpath | Pathway_IL4 | IL4 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD584 | VER 155008 | 3 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD309 | 17AAG | 2 |
| iGMDRD294 | Batimastat | 6 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD226 | ML006 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CXCR4
CLASSFICATION
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