STAT6


Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
signal transducer and activator of transcription 6MIM:601512Ensembl:ENSG00000166888HGNC:HGNC:11368PA33912q13.3

Gene Categories:

DRUGGABLE GENOME

GO terms in STAT6


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIPIGO:0019903protein phosphatase binding
MFIPIGO:0042802identical protein binding
CCIEAGO:0000790nuclear chromatin
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0031965nuclear membrane
CCIEAGO:0045121membrane raft
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0002296T-helper 1 cell lineage commitment
BPIEAGO:0002829negative regulation of type 2 immune response
BPTASGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006366transcription by RNA polymerase II
BPTASGO:0007165signal transduction
BPTASGO:0019221cytokine-mediated signaling pathway
BPTASGO:0032481positive regulation of type I interferon production
BPIEAGO:0033598mammary gland epithelial cell proliferation
BPIMPGO:0035771interleukin-4-mediated signaling pathway
BPIEAGO:0042127regulation of cell proliferation
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0048295positive regulation of isotype switching to IgE isotypes
BPIEAGO:0060443mammary gland morphogenesis
BPIEAGO:0070301cellular response to hydrogen peroxide
BPIEAGO:1902170cellular response to reactive nitrogen species

Gene expression in normal tissue: STAT6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STAT6


DatabasePathway IDPathway Des.
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP236Adipogenesis
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP3972PDGFR-beta pathway
pidil12_2pathwayIL12-mediated signaling events
pidil4_2pathwayIL4-mediated signaling events
pidtcptp_pathwaySignaling events mediated by TCPTP
netpathPathway_IL4IL4
netpathPathway_IL9IL9
netpathPathway_TSLPTSLP
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)
biocartail4pathwayil 4 signaling pathway
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-1834941STING mediated induction of host immune responses
reactomeR-HSA-1834949Cytosolic sensors of pathogen-associated DNA
reactomeR-HSA-186763Downstream signal transduction
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-3249367STAT6-mediated induction of chemokines
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD177Teniposide2
iGMDRD211(1S,3R)-RSL33
iGMDRD901ELCPK3
iGMDRD85Ursolic acid1
iGMDRD351GW843682X3
iGMDRD116CD4373
iGMDRD486Tosedostat3
iGMDRD148Pifithrin-mu3
iGMDRD512nutlin 36
iGMDRD246NPC265
iGMDRD505Pevonedistat3
iGMDRD886Compound 1541A3
iGMDRD872BRD71373
iGMDRD280CYTOCHALASIN B5
iGMDRD446LY 21832403
iGMDRD193Fqi12
iGMDRD494Neopeltolide2
iGMDRD1008SR-II-138A4
iGMDRD772BRD47703
iGMDRD60Quinoclamine2
iGMDRD451Serdemetan2
iGMDRD887Compound 23 citrate1
iGMDRD100Zebularine2
iGMDRD870BRD636103
iGMDRD441TW 373
iGMDRD318PAC-13
iGMDRD138PX 123
iGMDRD8024-methylfasudil1
iGMDRD255SB2250023
iGMDRD123Isoevodiamine3
iGMDRD945ML2144
iGMDRD341Triacsin c5
iGMDRD219Bax channel blocker3
iGMDRD698Neratinib3
iGMDRD150RITA2
iGMDRD405PIK-752
iGMDRD48Dexamethasone3
iGMDRD248BRD43543
iGMDRD263AACOCF32
iGMDRD322FK 8665
iGMDRD286Nsc 6328394
iGMDRD871BRD63683
iGMDRD329Merck602
iGMDRD105Triptolide5
iGMDRD289Parthenolide6
iGMDRD705Nakiterpiosin2
iGMDRD137Indisulam2
iGMDRD158NSC1415404
iGMDRD121GMX17785
iGMDRD202Curcumin2
iGMDRD103SN-383
iGMDRD466Chaetocin4
iGMDRD152179324-69-73
iGMDRD61Kinetin riboside8
iGMDRD670ML 2103
iGMDRD76Simvastatin2
iGMDRD126Tipifarnib2
iGMDRD420Leucascandrolide A5
iGMDRD64Parbendazole6
iGMDRD356PNU-746542
iGMDRD23Gossypol2
iGMDRD188Piperlongumine1
iGMDRD171Pemetrexed4
iGMDRD187BRD98763
iGMDRD474Avrainvillamide2
iGMDRD260FQI-22

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STAT6

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