STAT6
Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| signal transducer and activator of transcription 6 | MIM:601512 | Ensembl:ENSG00000166888 | HGNC:HGNC:11368 | PA339 | 12q13.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in STAT6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019903 | protein phosphatase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| CC | IEA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0031965 | nuclear membrane |
| CC | IEA | GO:0045121 | membrane raft |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0002296 | T-helper 1 cell lineage commitment |
| BP | IEA | GO:0002829 | negative regulation of type 2 immune response |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0032481 | positive regulation of type I interferon production |
| BP | IEA | GO:0033598 | mammary gland epithelial cell proliferation |
| BP | IMP | GO:0035771 | interleukin-4-mediated signaling pathway |
| BP | IEA | GO:0042127 | regulation of cell proliferation |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048295 | positive regulation of isotype switching to IgE isotypes |
| BP | IEA | GO:0060443 | mammary gland morphogenesis |
| BP | IEA | GO:0070301 | cellular response to hydrogen peroxide |
| BP | IEA | GO:1902170 | cellular response to reactive nitrogen species |
Gene expression in normal tissue: STAT6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STAT6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP3972 | PDGFR-beta pathway |
| pid | il12_2pathway | IL12-mediated signaling events |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL9 | IL9 |
| netpath | Pathway_TSLP | TSLP |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05321 | Inflammatory bowel disease (IBD) - Homo sapiens (human) |
| biocarta | il4pathway | il 4 signaling pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-1834941 | STING mediated induction of host immune responses |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-186763 | Downstream signal transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-3249367 | STAT6-mediated induction of chemokines |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD177 | Teniposide | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD486 | Tosedostat | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD512 | nutlin 3 | 6 |
| iGMDRD246 | NPC26 | 5 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD1008 | SR-II-138A | 4 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD802 | 4-methylfasudil | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD341 | Triacsin c | 5 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD150 | RITA | 2 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD48 | Dexamethasone | 3 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD263 | AACOCF3 | 2 |
| iGMDRD322 | FK 866 | 5 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD105 | Triptolide | 5 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD121 | GMX1778 | 5 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD61 | Kinetin riboside | 8 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD76 | Simvastatin | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD420 | Leucascandrolide A | 5 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD171 | Pemetrexed | 4 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD260 | FQI-2 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STAT6
CLASSFICATION
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