CDK11B

Summary: This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecyclin dependent kinase 11B
OMIM IDMIM:176873
Ensembl IDEnsembl:ENSG00000248333
HGNC IDHGNC:HGNC:1729
PHARMGKB IDPA26262
Map Location1p36.33

GO terms in CDK11B


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Term Type
Evidence Type
GO Term ID
GO Des.
BP NAS GO:0000278 mitotic cell cycle
BP IEP GO:0001558 regulation of cell growth
BP NAS GO:0006355 regulation of transcription, DNA-templated
BP IBA GO:0006468 protein phosphorylation
BP IDA GO:0006468 protein phosphorylation
BP NAS GO:0006915 apoptotic process
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Gene expression in normal tissue: CDK11B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined21IGFR signaling1PI3K/MTOR signaling1DNA replication1Th17 cell differentiation1Other, kinases1

Pathways in CDK11B


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Database
Pathway ID
Pathway Des.
biocarta hivnefpathway hiv-1 nef: negative effector of fas and tnf
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
reactome R-HSA-380287 Centrosome maturation
reactome R-HSA-453274 Mitotic G2-G2/M phases
reactome R-HSA-69275 G2/M Transition
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 4
iGMDRD270 Ciclosporin 2
iGMDRD158 NSC141540 2
iGMDRD474 Avrainvillamide 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDK11B

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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