CDK11B
Summary: This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase 11B | MIM:176873 | Ensembl:ENSG00000248333 | HGNC:HGNC:1729 | PA26262 | 1p36.33 |
GO terms in CDK11B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0000278 | mitotic cell cycle |
| BP | IEP | GO:0001558 | regulation of cell growth |
| BP | NAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | NAS | GO:0006915 | apoptotic process |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IBA | GO:0010468 | regulation of gene expression |
| BP | IDA | GO:0050684 | regulation of mRNA processing |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IEA | GO:0005737 | cytoplasm |
| MF | HDA | GO:0003723 | RNA binding |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
Gene expression in normal tissue: CDK11B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDK11B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| reactome | R-HSA-380287 | Centrosome maturation |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| humancyc | PWY-7434 | terminal O-glycans residues modification |
| pid | ar_pathway | Coregulation of Androgen receptor activity |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 4 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD269 | Purmorphamine | 1 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 4 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD394 | BX-795 | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDK11B
CLASSFICATION
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