TET1
Summary: DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tet methylcytosine dioxygenase 1 | MIM:607790 | Ensembl:ENSG00000138336 | HGNC:HGNC:29484 | PA162405605 | 10q21.3 |
GO terms in TET1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IBA | GO:0005506 | iron ion binding |
| MF | IDA | GO:0005506 | iron ion binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IBA | GO:0070579 | methylcytosine dioxygenase activity |
| MF | IDA | GO:0070579 | methylcytosine dioxygenase activity |
| MF | IMP | GO:0070579 | methylcytosine dioxygenase activity |
| BP | ISS | GO:0001826 | inner cell mass cell differentiation |
| BP | IBA | GO:0006211 | 5-methylcytosine catabolic process |
| BP | IEA | GO:0006325 | chromatin organization |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | ISS | GO:0006493 | protein O-linked glycosylation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | ISS | GO:0019827 | stem cell population maintenance |
| BP | IMP | GO:0031062 | positive regulation of histone methylation |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IBA | GO:0070989 | oxidative demethylation |
| BP | IBA | GO:0080111 | DNA demethylation |
| BP | IMP | GO:0080111 | DNA demethylation |
| BP | IMP | GO:0090310 | negative regulation of methylation-dependent chromatin silencing |
| CC | IBA | GO:0005634 | nucleus |
| CC | IC | GO:0005634 | nucleus |
Gene expression in normal tissue: TET1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TET1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| smpdb | SMP02291 | The oncogenic action of 2-hydroxyglutarate |
| smpdb | SMP02292 | The oncogenic action of Succinate |
| smpdb | SMP02295 | The oncogenic action of Fumarate |
| smpdb | SMP02358 | The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria |
| smpdb | SMP02359 | The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP3584 | MECP2 and Associated Rett Syndrome |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-5221030 | TET1,2,3 and TDG demethylate DNA |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD427 | ABT737 | 2 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 6 |
| iGMDRD152 | 179324-69-7 | 5 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD207 | Capsaicin | 3 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD562 | Navitoclax | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TET1
CLASSFICATION
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