TET1

Summary: DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nametet methylcytosine dioxygenase 1
OMIM IDMIM:607790
Ensembl IDEnsembl:ENSG00000138336
HGNC IDHGNC:HGNC:29484
PHARMGKB IDPA162405605
Map Location10q21.3

GO terms in TET1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IDA GO:0003677 DNA binding
MF IBA GO:0005506 iron ion binding
MF IDA GO:0005506 iron ion binding
MF IEA GO:0008270 zinc ion binding
MF IBA GO:0070579 methylcytosine dioxygenase activity
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Gene expression in normal tissue: TET1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

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Pathways in TET1


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Database
Pathway ID
Pathway Des.
smpdb SMP02291 The oncogenic action of 2-hydroxyglutarate
smpdb SMP02292 The oncogenic action of Succinate
smpdb SMP02295 The oncogenic action of Fumarate
smpdb SMP02358 The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria
smpdb SMP02359 The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria
wikipathways WP2857 Mesodermal Commitment Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD427 ABT737 2
iGMDRD781 Sirolimus 1
iGMDRD84 Lovastatin acid 1
iGMDRD126 Tipifarnib 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TET1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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