MRTFA
Summary: The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| myocardin related transcription factor A | MIM:606078 | Ensembl:ENSG00000196588 | HGNC:HGNC:14334 | PA30827 | 22q13.1-q13.2 |
GO terms in MRTFA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0010735 | positive regulation of transcription via serum response element binding |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0051145 | smooth muscle cell differentiation |
| BP | IMP | GO:0051145 | smooth muscle cell differentiation |
| MF | ISS | GO:0003713 | transcription coactivator activity |
| MF | IDA | GO:0003779 | actin binding |
| MF | ISS | GO:0003785 | actin monomer binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0043522 | leucine zipper domain binding |
Gene expression in normal tissue: MRTFA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MRTFA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | rhoa_pathway | RhoA signaling pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3899300 | SUMOylation of transcription cofactors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-597592 | Post-translational protein modification |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD318 | PAC-1 | 5 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 6 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD42 | Vorinostat | 4 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD219 | Bax channel blocker | 1 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD560 | MK-2206 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MRTFA
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