MRTFA


Summary: The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
myocardin related transcription factor AMIM:606078Ensembl:ENSG00000196588HGNC:HGNC:14334PA3082722q13.1-q13.2

GO terms in MRTFA


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
BPIEAGO:0006351transcription, DNA-templated
BPIDAGO:0010735positive regulation of transcription via serum response element binding
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIBAGO:0051145smooth muscle cell differentiation
BPIMPGO:0051145smooth muscle cell differentiation
MFISSGO:0003713transcription coactivator activity
MFIDAGO:0003779actin binding
MFISSGO:0003785actin monomer binding
MFIPIGO:0005515protein binding
MFIPIGO:0043522leucine zipper domain binding

Gene expression in normal tissue: MRTFA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MRTFA


DatabasePathway IDPathway Des.
pidrhoa_pathwayRhoA signaling pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3899300SUMOylation of transcription cofactors
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5663220RHO GTPases Activate Formins
reactomeR-HSA-597592Post-translational protein modification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD577BIX012942
iGMDRD562Navitoclax3
iGMDRD60Quinoclamine3
iGMDRD369TGX-1152
iGMDRD474Avrainvillamide2
iGMDRD318PAC-15
iGMDRD885Compound 1103
iGMDRD634SCHEMBL26080416
iGMDRD280CYTOCHALASIN B2
iGMDRD679Bistramide A1
iGMDRD394BX-7952
iGMDRD889Compound 7d-cis2
iGMDRD579PF7503
iGMDRD772BRD47703
iGMDRD126Tipifarnib4
iGMDRD781Sirolimus3
iGMDRD144NSC953972
iGMDRD329Merck602
iGMDRD286Nsc 6328393
iGMDRD871BRD63683
iGMDRD367Ro 28-16753
iGMDRD872BRD71373
iGMDRD42Vorinostat4
iGMDRD300Tozasertib3
iGMDRD552AZD-17753
iGMDRD137Indisulam3
iGMDRD158NSC1415402
iGMDRD434BMS-5369243
iGMDRD351GW843682X1
iGMDRD219Bax channel blocker1
iGMDRD85Ursolic acid1
iGMDRD435BI-25363
iGMDRD154NSC237663
iGMDRD148Pifithrin-mu3
iGMDRD307Manumycin A2
iGMDRD560MK-22062

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MRTFA

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