COL3A1

Summary: This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecollagen type III alpha 1 chain
OMIM IDMIM:120180
Ensembl IDEnsembl:ENSG00000168542
HGNC IDHGNC:HGNC:2201
PHARMGKB IDPA26716
Map Location2q32.2

Gene Categories:

DRUGGABLE GENOME

GO terms in COL3A1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC HDA GO:0005576 extracellular region
CC TAS GO:0005576 extracellular region
CC IBA GO:0005586 collagen type III trimer
CC IDA GO:0005586 collagen type III trimer
CC IMP GO:0005586 collagen type III trimer
CC NAS GO:0005586 collagen type III trimer
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Gene expression in normal tissue: COL3A1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined38PI3K/MTOR signaling2Stilbenoid, diarylheptanoid and gingerol biosynthesis1DNA replication1Apoptosis regulation1IGFR signaling1ERK MAPK signaling1p53 pathway1

Pathways in COL3A1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-1442490 Collagen degradation
reactome R-HSA-1442490 Collagen degradation
reactome R-HSA-1474228 Degradation of the extracellular matrix
reactome R-HSA-1474228 Degradation of the extracellular matrix
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD433 Lexibulin 6
iGMDRD599 Salermide 5
iGMDRD420 Leucascandrolide A 3
iGMDRD1008 SR-II-138A 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in COL3A1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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