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COL3A1

Summary: This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
collagen type III alpha 1 chain	MIM:120180	Ensembl:ENSG00000168542	HGNC:HGNC:2201	PA26716	2q32.2

Gene Categories:

DRUGGABLE GENOME

GO terms in COL3A1

Term Type	Evidence Type	GO Term ID	GO Des.
CC	HDA	GO:0005576	extracellular region
CC	TAS	GO:0005576	extracellular region
CC	IBA	GO:0005586	collagen type III trimer
CC	IDA	GO:0005586	collagen type III trimer
CC	IMP	GO:0005586	collagen type III trimer
CC	NAS	GO:0005586	collagen type III trimer
CC	IBA	GO:0005615	extracellular space
CC	IDA	GO:0005615	extracellular space
CC	NAS	GO:0005615	extracellular space
CC	TAS	GO:0005788	endoplasmic reticulum lumen
CC	IMP	GO:0031012	extracellular matrix
CC	HDA	GO:0062023	collagen-containing extracellular matrix
CC	TAS	GO:0062023	collagen-containing extracellular matrix
BP	IEA	GO:0001501	skeletal system development
BP	IDA	GO:0007160	cell-matrix adhesion
BP	IDA	GO:0007179	transforming growth factor beta receptor signaling pathway
BP	IMP	GO:0007229	integrin-mediated signaling pathway
BP	IMP	GO:0007507	heart development
BP	IEA	GO:0007568	aging
BP	IDA	GO:0009314	response to radiation
BP	IEA	GO:0009612	response to mechanical stimulus
BP	IDA	GO:0018149	peptide cross-linking
BP	ISS	GO:0021987	cerebral cortex development
BP	NAS	GO:0030168	platelet activation
BP	IBA	GO:0030198	extracellular matrix organization
BP	TAS	GO:0030198	extracellular matrix organization
BP	IMP	GO:0030199	collagen fibril organization
BP	NAS	GO:0030199	collagen fibril organization
BP	IDA	GO:0034097	response to cytokine
BP	ISS	GO:0035025	positive regulation of Rho protein signal transduction
BP	IDA	GO:0042060	wound healing
BP	NAS	GO:0042060	wound healing
BP	IMP	GO:0043588	skin development
BP	IEA	GO:0048565	digestive tract development
BP	TAS	GO:0050776	regulation of immune response
BP	IMP	GO:0050777	negative regulation of immune response
BP	IEA	GO:0060414	aorta smooth muscle tissue morphogenesis
BP	IEA	GO:0071230	cellular response to amino acid stimulus
BP	IMP	GO:0097435	supramolecular fiber organization
BP	ISS	GO:2001223	negative regulation of neuron migration
MF	IPI	GO:0002020	protease binding
MF	IMP	GO:0005178	integrin binding
MF	NAS	GO:0005178	integrin binding
MF	IBA	GO:0005201	extracellular matrix structural constituent
MF	IMP	GO:0005201	extracellular matrix structural constituent
MF	IPI	GO:0005515	protein binding
MF	HDA	GO:0030020	extracellular matrix structural constituent conferring tensile strength
MF	IEA	GO:0046332	SMAD binding
MF	IEA	GO:0046872	metal ion binding
MF	IDA	GO:0048407	platelet-derived growth factor binding

Gene expression in normal tissue: COL3A1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in COL3A1

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1280218	Adaptive Immune System
reactome	R-HSA-1442490	Collagen degradation
reactome	R-HSA-1442490	Collagen degradation
reactome	R-HSA-1474228	Degradation of the extracellular matrix
reactome	R-HSA-1474228	Degradation of the extracellular matrix
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1474244	Extracellular matrix organization
reactome	R-HSA-1474290	Collagen formation
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1650814	Collagen biosynthesis and modifying enzymes
reactome	R-HSA-168256	Immune System
reactome	R-HSA-186797	Signaling by PDGF
reactome	R-HSA-198933	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
reactome	R-HSA-2022090	Assembly of collagen fibrils and other multimeric structures
reactome	R-HSA-216083	Integrin cell surface interactions
reactome	R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors
reactome	R-HSA-3000170	Syndecan interactions
reactome	R-HSA-3000171	Non-integrin membrane-ECM interactions
reactome	R-HSA-3000171	Non-integrin membrane-ECM interactions
reactome	R-HSA-3000178	ECM proteoglycans
reactome	R-HSA-3000178	ECM proteoglycans
reactome	R-HSA-3000480	Scavenging by Class A Receptors
reactome	R-HSA-375165	NCAM signaling for neurite out-growth
reactome	R-HSA-419037	NCAM1 interactions
reactome	R-HSA-422475	Axon guidance
reactome	R-HSA-5653656	Vesicle-mediated transport
reactome	R-HSA-6806834	Signaling by MET
reactome	R-HSA-8874081	MET activates PTK2 signaling
reactome	R-HSA-8875878	MET promotes cell motility
reactome	R-HSA-8948216	Collagen chain trimerization
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
wikipathways	WP2002	miR-targeted genes in epithelium - TarBase
wikipathways	WP2005	miR-targeted genes in muscle cell - TarBase
wikipathways	WP2911	miRNA targets in ECM and membrane receptors
wikipathways	WP306	Focal Adhesion
wikipathways	WP3932	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways	WP3967	miR-509-3p alteration of YAP1-ECM axis
wikipathways	WP3980	Protein alkylation leading to liver fibrosis
wikipathways	WP453	Inflammatory Response Pathway
wikipathways	WP615	Senescence and Autophagy in Cancer
pharmgkb	PA154444041	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
pid	avb3_integrin_pathway	Integrins in angiogenesis
pid	endothelinpathway	Endothelins
pid	integrin1_pathway	Beta1 integrin cell surface interactions
pid	syndecan_1_pathway	Syndecan-1-mediated signaling events
kegg	hsa04611	Platelet activation - Homo sapiens (human)
kegg	hsa04926	Relaxin signaling pathway - Homo sapiens (human)
kegg	hsa04933	AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegg	hsa04974	Protein digestion and absorption - Homo sapiens (human)
kegg	hsa05146	Amoebiasis - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD433	Lexibulin	6
iGMDRD599	Salermide	5
iGMDRD420	Leucascandrolide A	3
iGMDRD1008	SR-II-138A	2
iGMDRD772	BRD4770	2
iGMDRD779	PRL-3 Inhibitor I	1
iGMDRD546	BMS-754807	2
iGMDRD494	Neopeltolide	4
iGMDRD718	Pyrvinium pamoate	1
iGMDRD193	Fqi1	1
iGMDRD466	Chaetocin	1
iGMDRD394	BX-795	3
iGMDRD359	OSW-1	2
iGMDRD474	Avrainvillamide	3
iGMDRD138	PX 12	5
iGMDRD255	SB225002	1
iGMDRD782	DC-45-A2	5
iGMDRD226	ML006	2
iGMDRD885	Compound 110	2
iGMDRD187	BRD9876	2
iGMDRD188	Piperlongumine	2
iGMDRD399	Selumetinib	2
iGMDRD577	BIX01294	1
iGMDRD562	Navitoclax	2
iGMDRD64	Parbendazole	1
iGMDRD524	ISX-9	2
iGMDRD451	Serdemetan	2
iGMDRD330	BRD4132	1
iGMDRD248	BRD4354	3
iGMDRD116	CD437	1
iGMDRD523	Cyanoquinoline, 11	2
iGMDRD405	PIK-75	3
iGMDRD177	Teniposide	3
iGMDRD154	NSC23766	4
iGMDRD202	Curcumin	6
iGMDRD158	NSC141540	3
iGMDRD105	Triptolide	1
iGMDRD434	BMS-536924	2
iGMDRD481	Dactolisib	2
iGMDRD267	Oligomycin A	1
iGMDRD77	Itraconazole	2
iGMDRD414	MST-312	5
iGMDRD329	Merck60	3
iGMDRD366	PI-103	1
iGMDRD505	Pevonedistat	5
iGMDRD246	NPC26	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in COL3A1

SITE

DATATYPES

CLASSFICATION

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