GHR


Summary: This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
growth hormone receptorMIM:600946Ensembl:ENSG00000112964HGNC:HGNC:4263PA286745p13.1-p12

GO terms in GHR


Term TypeEvidence TypeGO Term IDGO Des.
BPISSGO:0000187activation of MAPK activity
BPISSGO:0000255allantoin metabolic process
BPISSGO:0006101citrate metabolic process
BPISSGO:00061032-oxoglutarate metabolic process
BPISSGO:0006105succinate metabolic process
BPISSGO:0006107oxaloacetate metabolic process
BPISSGO:0006549isoleucine metabolic process
BPISSGO:0006573valine metabolic process
BPISSGO:0006600creatine metabolic process
BPISSGO:0006631fatty acid metabolic process
BPIEAGO:0006897endocytosis
BPISSGO:0007259JAK-STAT cascade
BPIEAGO:0019221cytokine-mediated signaling pathway
BPISSGO:0019530taurine metabolic process
BPIMPGO:0032870cellular response to hormone stimulus
BPISSGO:0040014regulation of multicellular organism growth
BPIMPGO:0040018positive regulation of multicellular organism growth
BPIMPGO:0042445hormone metabolic process
BPISSGO:0042531positive regulation of tyrosine phosphorylation of STAT protein
BPISSGO:0042976activation of Janus kinase activity
BPIBAGO:0046427positive regulation of JAK-STAT cascade
BPISSGO:0046449creatinine metabolic process
BPIMPGO:0048009insulin-like growth factor receptor signaling pathway
BPIBAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPISSGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
BPIBAGO:0060396growth hormone receptor signaling pathway
BPIMPGO:0060396growth hormone receptor signaling pathway
BPTASGO:0060397JAK-STAT cascade involved in growth hormone signaling pathway
CCTASGO:0005576extracellular region
CCIDAGO:0005615extracellular space
CCIMPGO:0005615extracellular space
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIBAGO:0009897external side of plasma membrane
CCIDAGO:0009986cell surface
CCIDAGO:0016021integral component of membrane
CCIDAGO:0036464cytoplasmic ribonucleoprotein granule
CCIBAGO:0043235receptor complex
CCIDAGO:0043235receptor complex
CCIBAGO:0070195growth hormone receptor complex
CCIDAGO:0070195growth hormone receptor complex
MFIBAGO:0004896cytokine receptor activity
MFIEAGO:0004896cytokine receptor activity
MFIBAGO:0004903growth hormone receptor activity
MFIPIGO:0005515protein binding
MFIBAGO:0017046peptide hormone binding
MFIPIGO:0017046peptide hormone binding
MFIBAGO:0019838growth factor binding
MFISSGO:0019901protein kinase binding
MFIBAGO:0019955cytokine binding
MFIPIGO:0042802identical protein binding
MFIDAGO:0042803protein homodimerization activity
MFISSGO:0070064proline-rich region binding

Gene expression in normal tissue: GHR

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GHR


DatabasePathway IDPathway Des.
reactomeR-HSA-1170546Prolactin receptor signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-982772Growth hormone receptor signaling
reactomeR-HSA-982772Growth hormone receptor signaling
biocartaaktpathwayakt signaling pathway
biocartaeif4pathwayregulation of eif-4e and p70s6 kinase
biocartaghpathwaygrowth hormone signaling pathway
biocartamtorpathwaymtor signaling pathway
biocartatffpathwaytrefoil factors initiate mucosal healing
pidhes_heypathwayNotch-mediated HES/HEY network
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
wikipathwaysWP2593JAK-STAT
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP474Endochondral Ossification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD300Tozasertib4
iGMDRD367Ro 28-16755
iGMDRD414MST-3121
iGMDRD269Purmorphamine1
iGMDRD329Merck604
iGMDRD434BMS-5369244
iGMDRD289Parthenolide3
iGMDRD267Oligomycin A3
iGMDRD213SMR0000686504
iGMDRD103SN-383
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD945ML2143
iGMDRD351GW843682X1
iGMDRD560MK-22066
iGMDRD248BRD43542
iGMDRD60Quinoclamine5
iGMDRD690PRIMA-1MET2
iGMDRD268Cerulenin3
iGMDRD23Gossypol5
iGMDRD399Selumetinib3
iGMDRD887Compound 23 citrate6
iGMDRD188Piperlongumine2
iGMDRD780PP-301
iGMDRD562Navitoclax7
iGMDRD398Sepantronium4
iGMDRD224Necrostatin-12
iGMDRD506Fedratinib5
iGMDRD52Rotenone2
iGMDRD441TW 372
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD474Avrainvillamide6
iGMDRD247Blebbistatin2
iGMDRD270Ciclosporin3
iGMDRD255SB2250022
iGMDRD8024-methylfasudil5
iGMDRD466Chaetocin3
iGMDRD297Austocystin D3
iGMDRD380Pifithrin-alpha5
iGMDRD375GW-4058336
iGMDRD201SKI II3
iGMDRD152179324-69-71
iGMDRD61Kinetin riboside3
iGMDRD316N9-Isopropyl-olomoucine3
iGMDRD427ABT7379
iGMDRD144NSC953971
iGMDRD546BMS-7548074
iGMDRD781Sirolimus3
iGMDRD494Neopeltolide3
iGMDRD420Leucascandrolide A3
iGMDRD579PF7505

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GHR

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