MYLK2

Summary: This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namemyosin light chain kinase 2
OMIM IDMIM:606566
Ensembl IDEnsembl:ENSG00000101306
HGNC IDHGNC:HGNC:16243
PHARMGKB IDPA31389
Map Location20q11.21

GO terms in MYLK2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISS GO:0004683 calmodulin-dependent protein kinase activity
MF IBA GO:0004687 myosin light chain kinase activity
MF IDA GO:0004687 myosin light chain kinase activity
MF ISS GO:0004687 myosin light chain kinase activity
MF IPI GO:0005515 protein binding
MF IC GO:0005516 calmodulin binding
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Gene expression in normal tissue: MYLK2

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 9undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 43BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 20

Gene-drug pathway distribution

undefined16Other, kinases1Cell cycle1

Pathways in MYLK2


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Database
Pathway ID
Pathway Des.
kegg hsa04020 Calcium signaling pathway - Homo sapiens (human)
kegg hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
kegg hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
kegg hsa04371 Apelin signaling pathway - Homo sapiens (human)
kegg hsa04510 Focal adhesion - Homo sapiens (human)
kegg hsa04611 Platelet activation - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD446 LY 2183240 6
iGMDRD341 Triacsin c 4
iGMDRD193 Fqi1 1
iGMDRD351 GW843682X 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MYLK2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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