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FYN

Summary: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameFYN proto-oncogene, Src family tyrosine kinase OMIM IDMIM:137025 Ensembl IDEnsembl:ENSG00000010810 HGNC IDHGNC:HGNC:4037 PHARMGKB IDPA28454 Map Location6q21

Gene Categories:

KINASE DRUG RESISTANCE DRUGGABLE GENOME TYROSINE KINASE

GO terms in FYN

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	TAS	GO:0000165	MAPK cascade
BP	ISS	GO:0000304	response to singlet oxygen
BP	IEA	GO:0001764	neuron migration
BP	TAS	GO:0002223	stimulatory C-type lectin receptor signaling pathway
BP	IEA	GO:0002250	adaptive immune response
BP	IGI	GO:0003015	heart process

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Gene expression in normal tissue: FYN

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FYN

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Database	Pathway ID	Pathway Des.
biocarta	biopeptidespathway	bioactive peptide induced signaling pathway
biocarta	il7pathway	il-7 signal transduction
biocarta	integrinpathway	integrin signaling pathway
biocarta	mef2dpathway	role of mef2d in t-cell apoptosis
biocarta	tcrapathway	lck and fyn tyrosine kinases in initiation of tcr activation
biocarta	tcrpathway	t cell receptor signaling pathway

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD446	LY 2183240	1
iGMDRD351	GW843682X	3
iGMDRD57	Chloropentafluorobenzene	2
iGMDRD61	Kinetin riboside	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FYN

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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