FYN
Summary: This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| FYN proto-oncogene, Src family tyrosine kinase | MIM:137025 | Ensembl:ENSG00000010810 | HGNC:HGNC:4037 | PA28454 | 6q21 |
GO terms in FYN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | ISS | GO:0000304 | response to singlet oxygen |
| BP | IEA | GO:0001764 | neuron migration |
| BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | IGI | GO:0003015 | heart process |
| BP | NAS | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | NAS | GO:0006816 | calcium ion transport |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | TAS | GO:0007411 | axon guidance |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | TAS | GO:0007612 | learning |
| BP | TAS | GO:0007631 | feeding behavior |
| BP | ISS | GO:0008360 | regulation of cell shape |
| BP | IEA | GO:0010629 | negative regulation of gene expression |
| BP | ISS | GO:0010730 | negative regulation of hydrogen peroxide biosynthetic process |
| BP | IEA | GO:0010976 | positive regulation of neuron projection development |
| BP | IEA | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| BP | IMP | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | ISS | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | TAS | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IEA | GO:0030900 | forebrain development |
| BP | TAS | GO:0031295 | T cell costimulation |
| BP | IEA | GO:0031397 | negative regulation of protein ubiquitination |
| BP | TAS | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0036120 | cellular response to platelet-derived growth factor stimulus |
| BP | IBA | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | IBA | GO:0042110 | T cell activation |
| BP | IBA | GO:0042127 | regulation of cell proliferation |
| BP | IEA | GO:0042177 | negative regulation of protein catabolic process |
| BP | IEA | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | ISS | GO:0042542 | response to hydrogen peroxide |
| BP | IBA | GO:0042981 | regulation of apoptotic process |
| BP | IEA | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IBA | GO:0045087 | innate immune response |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | TAS | GO:0048013 | ephrin receptor signaling pathway |
| BP | IEA | GO:0048813 | dendrite morphogenesis |
| BP | TAS | GO:0050690 | regulation of defense response to virus by virus |
| BP | ISS | GO:0050730 | regulation of peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0050798 | activated T cell proliferation |
| BP | IBA | GO:0050852 | T cell receptor signaling pathway |
| BP | IDA | GO:0050852 | T cell receptor signaling pathway |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IEA | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IEA | GO:0071375 | cellular response to peptide hormone stimulus |
| BP | IEA | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| BP | ISS | GO:0090314 | positive regulation of protein targeting to membrane |
| BP | TAS | GO:0097062 | dendritic spine maintenance |
| BP | IEA | GO:1900182 | positive regulation of protein localization to nucleus |
| BP | ISS | GO:1900449 | regulation of glutamate receptor signaling pathway |
| BP | ISS | GO:1901216 | positive regulation of neuron death |
| BP | ISS | GO:1902951 | negative regulation of dendritic spine maintenance |
| BP | ISS | GO:1903202 | negative regulation of oxidative stress-induced cell death |
| BP | TAS | GO:1903997 | positive regulation of non-membrane spanning protein tyrosine kinase activity |
| BP | ISS | GO:1904645 | response to amyloid-beta |
| BP | ISS | GO:1905232 | cellular response to L-glutamate |
| BP | ISS | GO:1905430 | cellular response to glycine |
| BP | TAS | GO:1905477 | positive regulation of protein localization to membrane |
| BP | ISS | GO:1905664 | regulation of calcium ion import across plasma membrane |
| BP | ISS | GO:2001056 | positive regulation of cysteine-type endopeptidase activity |
| BP | IEA | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| CC | ISS | GO:0005634 | nucleus |
| CC | ISS | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005768 | endosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005884 | actin filament |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0014069 | postsynaptic density |
| CC | ISS | GO:0030425 | dendrite |
| CC | IBA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | ISS | GO:0044297 | cell body |
| CC | IDA | GO:0045121 | membrane raft |
| CC | IMP | GO:0045121 | membrane raft |
| CC | ISS | GO:0045121 | membrane raft |
| CC | TAS | GO:0045121 | membrane raft |
| CC | ISS | GO:0048471 | perinuclear region of cytoplasm |
| CC | ISS | GO:0097038 | perinuclear endoplasmic reticulum |
| CC | ISS | GO:0097386 | glial cell projection |
| MF | EXP | GO:0004713 | protein tyrosine kinase activity |
| MF | IMP | GO:0004713 | protein tyrosine kinase activity |
| MF | ISS | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | NAS | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | ISS | GO:0031802 | type 5 metabotropic glutamate receptor binding |
| MF | IEA | GO:0042608 | T cell receptor binding |
| MF | IEA | GO:0042609 | CD4 receptor binding |
| MF | IEA | GO:0042610 | CD8 receptor binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | ISS | GO:0043014 | alpha-tubulin binding |
| MF | IEA | GO:0043548 | phosphatidylinositol 3-kinase binding |
| MF | IEA | GO:0044325 | ion channel binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IPI | GO:0046875 | ephrin receptor binding |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| MF | ISS | GO:0048156 | tau protein binding |
| MF | TAS | GO:0048156 | tau protein binding |
| MF | IEA | GO:0051428 | peptide hormone receptor binding |
| MF | IPI | GO:0070851 | growth factor receptor binding |
| MF | IPI | GO:0097718 | disordered domain specific binding |
Gene expression in normal tissue: FYN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FYN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | il7pathway | il-7 signal transduction |
| biocarta | integrinpathway | integrin signaling pathway |
| biocarta | mef2dpathway | role of mef2d in t-cell apoptosis |
| biocarta | tcrapathway | lck and fyn tyrosine kinases in initiation of tcr activation |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| biocarta | tsp1pathway | tsp-1 induced apoptosis in microvascular endothelial cell |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-1433559 | Regulation of KIT signaling |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-164944 | Nef and signal transduction |
| reactome | R-HSA-164952 | The role of Nef in HIV-1 replication and disease pathogenesis |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029481 | FCGR activation |
| reactome | R-HSA-210990 | PECAM1 interactions |
| reactome | R-HSA-2172127 | DAP12 interactions |
| reactome | R-HSA-2172127 | DAP12 interactions |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-2424491 | DAP12 signaling |
| reactome | R-HSA-2424491 | DAP12 signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2682334 | EPH-Ephrin signaling |
| reactome | R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-373752 | Netrin-1 signaling |
| reactome | R-HSA-373753 | Nephrin family interactions |
| reactome | R-HSA-373753 | Nephrin family interactions |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-375165 | NCAM signaling for neurite out-growth |
| reactome | R-HSA-375165 | NCAM signaling for neurite out-growth |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389356 | CD28 co-stimulation |
| reactome | R-HSA-389357 | CD28 dependent PI3K/Akt signaling |
| reactome | R-HSA-389359 | CD28 dependent Vav1 pathway |
| reactome | R-HSA-389513 | CTLA4 inhibitory signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928662 | EPHB-mediated forward signaling |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928663 | EPHA-mediated growth cone collapse |
| reactome | R-HSA-3928664 | Ephrin signaling |
| reactome | R-HSA-3928664 | Ephrin signaling |
| reactome | R-HSA-3928665 | EPH-ephrin mediated repulsion of cells |
| reactome | R-HSA-399954 | Sema3A PAK dependent Axon repulsion |
| reactome | R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| reactome | R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| reactome | R-HSA-399956 | CRMPs in Sema3A signaling |
| reactome | R-HSA-399956 | CRMPs in Sema3A signaling |
| reactome | R-HSA-418885 | DCC mediated attractive signaling |
| reactome | R-HSA-418885 | DCC mediated attractive signaling |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-5621480 | Dectin-2 family |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-5621575 | CD209 (DC-SIGN) signaling |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-75892 | Platelet Adhesion to exposed collagen |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-8866376 | Reelin signalling pathway |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9032500 | Activated NTRK2 signals through FYN |
| reactome | R-HSA-9032500 | Activated NTRK2 signals through FYN |
| reactome | R-HSA-9032759 | NTRK2 activates RAC1 |
| reactome | R-HSA-9032759 | NTRK2 activates RAC1 |
| reactome | R-HSA-912631 | Regulation of signaling by CBL |
| reactome | R-HSA-912631 | Regulation of signaling by CBL |
| reactome | R-HSA-983695 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP205 | IL-7 Signaling Pathway |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP2272 | Pathogenic Escherichia coli infection |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP2583 | T-Cell Receptor and Co-stimulatory Signaling |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3995 | Prion disease pathway |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP585 | Interferon type I signaling pathways |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| smpdb | SMP00358 | Fc Epsilon Receptor I Signaling in Mast Cells |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | alphasynuclein_pathway | Alpha-synuclein signaling |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | ecadherin_keratinocyte_pathway | E-cadherin signaling in keratinocytes |
| pid | epha_fwdpathway | EPHA forward signaling |
| pid | ephrinarevpathway | Ephrin A reverse signaling |
| pid | ephrinbrevpathway | Ephrin B reverse signaling |
| pid | erbb4_pathway | ErbB4 signaling events |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | glypican_1pathway | Glypican 1 network |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | nephrin_neph1_pathway | Nephrin/Neph1 signaling in the kidney podocyte |
| pid | netrin_pathway | Netrin-mediated signaling events |
| pid | p38alphabetapathway | Regulation of p38-alpha and p38-beta |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | reelinpathway | Reelin signaling pathway |
| pid | syndecan_3_pathway | Syndecan-3-mediated signaling events |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Ghrelin | Ghrelin |
| netpath | Pathway_IL-7 | IL-7 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_TCR | TCR |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa05020 | Prion diseases - Homo sapiens (human) |
| kegg | hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05416 | Viral myocarditis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD309 | 17AAG | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FYN
CLASSFICATION
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