FES
Summary: This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| FES proto-oncogene, tyrosine kinase | MIM:190030 | Ensembl:ENSG00000182511 | HGNC:HGNC:3657 | PA28098 | 15q26.1 |
GO terms in FES
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0015630 | microtubule cytoskeleton |
| CC | IBA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | IDA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | IDA | GO:0031410 | cytoplasmic vesicle |
| BP | IEA | GO:0001578 | microtubule bundle formation |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0006935 | chemotaxis |
| BP | IEA | GO:0007098 | centrosome cycle |
| BP | IBA | GO:0007155 | cell adhesion |
| BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IMP | GO:0008360 | regulation of cell shape |
| BP | IMP | GO:0010976 | positive regulation of neuron projection development |
| BP | IBA | GO:0016477 | cell migration |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IMP | GO:0030155 | regulation of cell adhesion |
| BP | IMP | GO:0031116 | positive regulation of microtubule polymerization |
| BP | IBA | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | IBA | GO:0042127 | regulation of cell proliferation |
| BP | IMP | GO:0042127 | regulation of cell proliferation |
| BP | IBA | GO:0043304 | regulation of mast cell degranulation |
| BP | IMP | GO:0043304 | regulation of mast cell degranulation |
| BP | IBA | GO:0045087 | innate immune response |
| BP | IMP | GO:0045595 | regulation of cell differentiation |
| BP | IMP | GO:0045639 | positive regulation of myeloid cell differentiation |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | TAS | GO:0060627 | regulation of vesicle-mediated transport |
| BP | IMP | GO:2000145 | regulation of cell motility |
| BP | IMP | GO:2000251 | positive regulation of actin cytoskeleton reorganization |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IDA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IBA | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0008017 | microtubule binding |
| MF | IDA | GO:0034987 | immunoglobulin receptor binding |
| MF | IDA | GO:0035091 | phosphatidylinositol binding |
Gene expression in normal tissue: FES
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FES
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_IL11 | IL11 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_KitReceptor | KitReceptor |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-399954 | Sema3A PAK dependent Axon repulsion |
| reactome | R-HSA-399955 | SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| reactome | R-HSA-399956 | CRMPs in Sema3A signaling |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD138 | PX 12 | 1 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD554 | CHEMBL1434137 | 6 |
| iGMDRD599 | Salermide | 6 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD107 | Valdecoxib | 3 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD434 | BMS-536924 | 5 |
| iGMDRD267 | Oligomycin A | 7 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD367 | Ro 28-1675 | 6 |
| iGMDRD300 | Tozasertib | 6 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD330 | BRD4132 | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD154 | NSC23766 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FES
CLASSFICATION
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