FES
Summary: This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:190030 Ensembl IDEnsembl:ENSG00000182511 HGNC IDHGNC:HGNC:3657 PHARMGKB IDPA28098 Map Location15q26.1 | |||||
GO terms in FES
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0015630 | microtubule cytoskeleton |
| CC | IBA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
Gene expression in normal tissue: FES
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FES
Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_IL11 | IL11 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_KitReceptor | KitReceptor |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | il4_2pathway | IL4-mediated signaling events |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FES
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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