FES


Summary: This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
FES proto-oncogene, tyrosine kinaseMIM:190030Ensembl:ENSG00000182511HGNC:HGNC:3657PA2809815q26.1

GO terms in FES


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005737cytoplasm
CCIEAGO:0005794Golgi apparatus
CCTASGO:0005829cytosol
CCIDAGO:0005925focal adhesion
CCIDAGO:0015630microtubule cytoskeleton
CCIBAGO:0031234extrinsic component of cytoplasmic side of plasma membrane
CCIDAGO:0031234extrinsic component of cytoplasmic side of plasma membrane
CCIDAGO:0031410cytoplasmic vesicle
BPIEAGO:0001578microtubule bundle formation
BPTASGO:0006468protein phosphorylation
BPIBAGO:0006935chemotaxis
BPIEAGO:0007098centrosome cycle
BPIBAGO:0007155cell adhesion
BPIBAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPTASGO:0007275multicellular organism development
BPTASGO:0008283cell proliferation
BPIMPGO:0008360regulation of cell shape
BPIMPGO:0010976positive regulation of neuron projection development
BPIBAGO:0016477cell migration
BPIDAGO:0018108peptidyl-tyrosine phosphorylation
BPIBAGO:0030154cell differentiation
BPIMPGO:0030155regulation of cell adhesion
BPIMPGO:0031116positive regulation of microtubule polymerization
BPIBAGO:0038083peptidyl-tyrosine autophosphorylation
BPIBAGO:0042127regulation of cell proliferation
BPIMPGO:0042127regulation of cell proliferation
BPIBAGO:0043304regulation of mast cell degranulation
BPIMPGO:0043304regulation of mast cell degranulation
BPIBAGO:0045087innate immune response
BPIMPGO:0045595regulation of cell differentiation
BPIMPGO:0045639positive regulation of myeloid cell differentiation
BPIDAGO:0046777protein autophosphorylation
BPTASGO:0060627regulation of vesicle-mediated transport
BPIMPGO:2000145regulation of cell motility
BPIMPGO:2000251positive regulation of actin cytoskeleton reorganization
MFIDAGO:0004713protein tyrosine kinase activity
MFTASGO:0004713protein tyrosine kinase activity
MFIBAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIDAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIBAGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0008017microtubule binding
MFIDAGO:0034987immunoglobulin receptor binding
MFIDAGO:0035091phosphatidylinositol binding

Gene expression in normal tissue: FES

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FES


DatabasePathway IDPathway Des.
netpathPathway_IL11IL11
netpathPathway_IL3IL3
netpathPathway_IL4IL4
netpathPathway_KitReceptorKitReceptor
pidangiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
pidil4_2pathwayIL4-mediated signaling events
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
kegghsa04360Axon guidance - Homo sapiens (human)
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP2332Interleukin-11 Signaling Pathway
wikipathwaysWP395IL-4 Signaling Pathway
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1433557Signaling by SCF-KIT
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-373755Semaphorin interactions
reactomeR-HSA-373755Semaphorin interactions
reactomeR-HSA-399954Sema3A PAK dependent Axon repulsion
reactomeR-HSA-399955SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
reactomeR-HSA-399956CRMPs in Sema3A signaling
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD138PX 121
iGMDRD474Avrainvillamide2
iGMDRD255SB2250021
iGMDRD885Compound 1103
iGMDRD318PAC-16
iGMDRD506Fedratinib5
iGMDRD60Quinoclamine2
iGMDRD126Tipifarnib3
iGMDRD554CHEMBL14341376
iGMDRD599Salermide6
iGMDRD420Leucascandrolide A3
iGMDRD779PRL-3 Inhibitor I1
iGMDRD781Sirolimus6
iGMDRD446LY 21832402
iGMDRD107Valdecoxib3
iGMDRD679Bistramide A1
iGMDRD280CYTOCHALASIN B2
iGMDRD158NSC1415403
iGMDRD105Triptolide2
iGMDRD6AM-5803
iGMDRD434BMS-5369245
iGMDRD267Oligomycin A7
iGMDRD871BRD63686
iGMDRD367Ro 28-16756
iGMDRD300Tozasertib6
iGMDRD886Compound 1541A3
iGMDRD552AZD-17753
iGMDRD82Quiflapon2
iGMDRD84Lovastatin acid3
iGMDRD486Tosedostat1
iGMDRD330BRD41321
iGMDRD512nutlin 33
iGMDRD248BRD43541
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD424Tamatinib3
iGMDRD351GW843682X1
iGMDRD177Teniposide3
iGMDRD435BI-25363
iGMDRD154NSC237663

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FES

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