Summary: Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008].

protein kinase C thetaMIM:600448Ensembl:ENSG00000065675HGNC:HGNC:9410PA3377310p15.1

GO terms in PRKCQ

Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004672protein kinase activity
MFEXPGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFNASGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIEAGO:0004697protein kinase C activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0046872metal ion binding
BPNASGO:0001558regulation of cell growth
BPISSGO:0006355regulation of transcription, DNA-templated
BPISSGO:0006509membrane protein ectodomain proteolysis
BPIEAGO:0006954inflammatory response
BPTASGO:0007411axon guidance
BPIBAGO:0018105peptidyl-serine phosphorylation
BPTASGO:0030168platelet activation
BPIMPGO:0032212positive regulation of telomere maintenance via telomerase
BPISSGO:0032740positive regulation of interleukin-17 production
BPISSGO:0032753positive regulation of interleukin-4 production
BPIBAGO:0035556intracellular signal transduction
BPNASGO:0035556intracellular signal transduction
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPIEAGO:0042102positive regulation of T cell proliferation
BPIEAGO:0045086positive regulation of interleukin-2 biosynthetic process
BPTASGO:0045652regulation of megakaryocyte differentiation
BPIMPGO:0046627negative regulation of insulin receptor signaling pathway
BPTASGO:0050852T cell receptor signaling pathway
BPISSGO:0050870positive regulation of T cell activation
BPIDAGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIMPGO:0051973positive regulation of telomerase activity
BPIMPGO:0060326cell chemotaxis
BPIMPGO:0070233negative regulation of T cell apoptotic process
BPISSGO:0090330regulation of platelet aggregation
BPIMPGO:1904355positive regulation of telomere capping
BPISSGO:2000318positive regulation of T-helper 17 type immune response
BPISSGO:2000570positive regulation of T-helper 2 cell activation
CCIEAGO:0001772immunological synapse
CCIDAGO:0005815microtubule organizing center
CCTASGO:0005886plasma membrane

Gene expression in normal tissue: PRKCQ

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKCQ

DatabasePathway IDPathway Des.
pharmgkbPA2024Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
pharmgkbPA2032VEGF Signaling Pathway
pidcd8tcrdownstreampathwayDownstream signaling in naïve CD8+ T cells
pidcd8tcrpathwayTCR signaling in naïve CD8+ T cells
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
pidtcr_pathwayTCR signaling in naïve CD4+ T cells
pidtxa2pathwayThromboxane A2 receptor signaling
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
wikipathwaysWP2012miRs in Muscle Cell Differentiation
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP3301MFAP5-mediated ovarian cancer cell motility and invasiveness
wikipathwaysWP35G Protein Signaling Pathways
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4132RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
wikipathwaysWP481Insulin Signaling
wikipathwaysWP536Calcium Regulation in the Cardiac Cell
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
reactomeR-HSA-111465Apoptotic cleavage of cellular proteins
reactomeR-HSA-114508Effects of PIP2 hydrolysis
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2187338Visual phototransduction
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2514856The phototransduction cascade
reactomeR-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascade
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373752Netrin-1 signaling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-418597G alpha (z) signalling events
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-75153Apoptotic execution phase
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
biocartakeratinocytepathwaykeratinocyte differentiation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD267Oligomycin A4
iGMDRD286Nsc 6328396
iGMDRD887Compound 23 citrate2
iGMDRD512nutlin 31
iGMDRD889Compound 7d-cis3
iGMDRD341Triacsin c3
iGMDRD446LY 21832403

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKCQ