NUAK1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NUAK family kinase 1 | MIM:608130 | Ensembl:ENSG00000074590 | HGNC:HGNC:14311 | PA142671242 | 12q23.3 |
GO terms in NUAK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0002039 | p53 binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004679 | AMP-activated protein kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0035174 | histone serine kinase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IDA | GO:0030155 | regulation of cell adhesion |
| BP | IDA | GO:0035507 | regulation of myosin-light-chain-phosphatase activity |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0042127 | regulation of cell proliferation |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
| BP | IDA | GO:2000772 | regulation of cellular senescence |
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0015630 | microtubule cytoskeleton |
Gene expression in normal tissue: NUAK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NUAK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD441 | TW 37 | 1 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD105 | Triptolide | 5 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD446 | LY 2183240 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NUAK1
CLASSFICATION
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