MECOM


Summary: The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
MDS1 and EVI1 complex locusMIM:165215Ensembl:ENSG00000085276HGNC:HGNC:3498PA279123q26.2

GO terms in MECOM


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006915apoptotic process
BPIEAGO:0030154cell differentiation
BPIEAGO:0034968histone lysine methylation
BPIMPGO:0043069negative regulation of programmed cell death
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0046329negative regulation of JNK cascade
BPIDAGO:0051726regulation of cell cycle
BPISSGO:0071425hematopoietic stem cell proliferation
CCIDAGO:0000118histone deacetylase complex
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCTASGO:0005829cytosol
CCIDAGO:0016607nuclear speck
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISSGO:0003677DNA binding
MFIDAGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFTASGO:0018024histone-lysine N-methyltransferase activity
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: MECOM

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MECOM


DatabasePathway IDPathway Des.
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-3214841PKMTs methylate histone lysines
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-6807070PTEN Regulation
reactomeR-HSA-6807070PTEN Regulation
reactomeR-HSA-8943724Regulation of PTEN gene transcription
reactomeR-HSA-8943724Regulation of PTEN gene transcription
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006925Intracellular signaling by second messengers
wikipathwaysWP3946White fat cell differentiation
wikipathwaysWP4149White fat cell differentiation
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD150RITA2
iGMDRD560MK-22063
iGMDRD79Gemcitabine2
iGMDRD405PIK-753
iGMDRD276AS 6052401
iGMDRD341Triacsin c4
iGMDRD123Isoevodiamine3
iGMDRD154NSC237663
iGMDRD945ML2143
iGMDRD39Pyrimethamine1
iGMDRD137Indisulam1
iGMDRD158NSC1415405
iGMDRD121GMX17784
iGMDRD103SN-383
iGMDRD105Triptolide3
iGMDRD289Parthenolide6
iGMDRD705Nakiterpiosin9
iGMDRD286Nsc 6328394
iGMDRD871BRD63683
iGMDRD366PI-1031
iGMDRD662JQ-13
iGMDRD433Lexibulin2
iGMDRD151CHM-14
iGMDRD126Tipifarnib7
iGMDRD420Leucascandrolide A6
iGMDRD484Pluripotin3
iGMDRD483SCH-5290742
iGMDRD152179324-69-72
iGMDRD61Kinetin riboside3
iGMDRD316N9-Isopropyl-olomoucine2
iGMDRD466Chaetocin4
iGMDRD474Avrainvillamide1
iGMDRD513BML-2592
iGMDRD260FQI-23
iGMDRD52Rotenone1
iGMDRD187BRD98766
iGMDRD1019TL-2-1051
iGMDRD399Selumetinib1
iGMDRD74Idarubicin8
iGMDRD188Piperlongumine5
iGMDRD506Fedratinib5
iGMDRD64Parbendazole2
iGMDRD369TGX-1151
iGMDRD356PNU-746542
iGMDRD307Manumycin A1
iGMDRD84Lovastatin acid3
iGMDRD512nutlin 33
iGMDRD345Compound 10b [PMID: 11504634]1
iGMDRD424Tamatinib3
iGMDRD116CD4375
iGMDRD536PLX-47201
iGMDRD351GW843682X3
iGMDRD178MG-1321
iGMDRD901ELCPK3
iGMDRD267Oligomycin A1
iGMDRD481Dactolisib1
iGMDRD415LE-1351
iGMDRD872BRD71375
iGMDRD269Purmorphamine2
iGMDRD246NPC263
iGMDRD505Pevonedistat6
iGMDRD82Quiflapon2
iGMDRD772BRD47704
iGMDRD1008SR-II-138A3
iGMDRD579PF7502
iGMDRD387CHIR-990211
iGMDRD144NSC953972
iGMDRD129SB-2167631
iGMDRD494Neopeltolide2
iGMDRD446LY 21832404
iGMDRD193Fqi14
iGMDRD280CYTOCHALASIN B5
iGMDRD138PX 123
iGMDRD298L-6854582
iGMDRD255SB2250024
iGMDRD8024-methylfasudil3
iGMDRD441TW 372
iGMDRD318PAC-12
iGMDRD887Compound 23 citrate3
iGMDRD100Zebularine3
iGMDRD562Navitoclax2
iGMDRD451Serdemetan1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MECOM

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