MECOM

Summary: The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameMDS1 and EVI1 complex locus
OMIM IDMIM:165215
Ensembl IDEnsembl:ENSG00000085276
HGNC IDHGNC:HGNC:3498
PHARMGKB IDPA27912
Map Location3q26.2

GO terms in MECOM


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0006351 transcription, DNA-templated
BP IEA GO:0006357 regulation of transcription by RNA polymerase II
BP IEA GO:0006915 apoptotic process
BP IEA GO:0030154 cell differentiation
BP IEA GO:0034968 histone lysine methylation
BP IMP GO:0043069 negative regulation of programmed cell death
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Gene expression in normal tissue: MECOM

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined60PI3K/MTOR signaling4Apoptosis regulation3ERK MAPK signaling2DNA replication2WNT signaling2Cell cycle1p53 pathway1Protein stability and degradation1Biosynthesis of secondary metabolites1

Pathways in MECOM


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1257604 PIP3 activates AKT signaling
reactome R-HSA-1257604 PIP3 activates AKT signaling
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-3214841 PKMTs methylate histone lysines
reactome R-HSA-3247509 Chromatin modifying enzymes
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD150 RITA 2
iGMDRD560 MK-2206 3
iGMDRD79 Gemcitabine 2
iGMDRD405 PIK-75 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MECOM

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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