MECOM
Summary: The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| MDS1 and EVI1 complex locus | MIM:165215 | Ensembl:ENSG00000085276 | HGNC:HGNC:3498 | PA27912 | 3q26.2 |
GO terms in MECOM
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0034968 | histone lysine methylation |
| BP | IMP | GO:0043069 | negative regulation of programmed cell death |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0046329 | negative regulation of JNK cascade |
| BP | IDA | GO:0051726 | regulation of cell cycle |
| BP | ISS | GO:0071425 | hematopoietic stem cell proliferation |
| CC | IDA | GO:0000118 | histone deacetylase complex |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016607 | nuclear speck |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISS | GO:0003677 | DNA binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0018024 | histone-lysine N-methyltransferase activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: MECOM
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MECOM
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-3214841 | PKMTs methylate histone lysines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| wikipathways | WP3946 | White fat cell differentiation |
| wikipathways | WP4149 | White fat cell differentiation |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD150 | RITA | 2 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD276 | AS 605240 | 1 |
| iGMDRD341 | Triacsin c | 4 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD39 | Pyrimethamine | 1 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD158 | NSC141540 | 5 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD705 | Nakiterpiosin | 9 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD126 | Tipifarnib | 7 |
| iGMDRD420 | Leucascandrolide A | 6 |
| iGMDRD484 | Pluripotin | 3 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD187 | BRD9876 | 6 |
| iGMDRD1019 | TL-2-105 | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD74 | Idarubicin | 8 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD369 | TGX-115 | 1 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD307 | Manumycin A | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 1 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD116 | CD437 | 5 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD178 | MG-132 | 1 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD415 | LE-135 | 1 |
| iGMDRD872 | BRD7137 | 5 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD772 | BRD4770 | 4 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD129 | SB-216763 | 1 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD298 | L-685458 | 2 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD451 | Serdemetan | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MECOM
CLASSFICATION
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