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VEGFD

Summary: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
vascular endothelial growth factor D	MIM:300091	Ensembl:ENSG00000165197	HGNC:HGNC:3708	PA28146	Xp22.2

Gene Categories:

DRUGGABLE GENOME GROWTH FACTOR

GO terms in VEGFD

Term Type	Evidence Type	GO Term ID	GO Des.
CC	TAS	GO:0005576	extracellular region
CC	IBA	GO:0005615	extracellular space
CC	IEA	GO:0016020	membrane
CC	TAS	GO:0031093	platelet alpha granule lumen
BP	IBA	GO:0001525	angiogenesis
BP	IBA	GO:0001666	response to hypoxia
BP	IBA	GO:0001934	positive regulation of protein phosphorylation
BP	IBA	GO:0001938	positive regulation of endothelial cell proliferation
BP	IBA	GO:0002040	sprouting angiogenesis
BP	TAS	GO:0002576	platelet degranulation
BP	IEA	GO:0008283	cell proliferation
BP	TAS	GO:0008284	positive regulation of cell proliferation
BP	IEA	GO:0010469	regulation of signaling receptor activity
BP	IBA	GO:0038084	vascular endothelial growth factor signaling pathway
BP	IBA	GO:0045766	positive regulation of angiogenesis
BP	IBA	GO:0048010	vascular endothelial growth factor receptor signaling pathway
BP	TAS	GO:0048010	vascular endothelial growth factor receptor signaling pathway
BP	IEA	GO:0050918	positive chemotaxis
BP	IBA	GO:0050930	induction of positive chemotaxis
BP	IDA	GO:0050930	induction of positive chemotaxis
BP	IEA	GO:0051781	positive regulation of cell division
BP	IBA	GO:0060754	positive regulation of mast cell chemotaxis
BP	IDA	GO:0060754	positive regulation of mast cell chemotaxis
BP	IEA	GO:0071542	dopaminergic neuron differentiation
MF	TAS	GO:0005161	platelet-derived growth factor receptor binding
MF	IPI	GO:0005172	vascular endothelial growth factor receptor binding
MF	IPI	GO:0005515	protein binding
MF	IBA	GO:0008083	growth factor activity
MF	IBA	GO:0042056	chemoattractant activity
MF	IDA	GO:0042056	chemoattractant activity
MF	IEA	GO:0042803	protein homodimerization activity
MF	IBA	GO:0043185	vascular endothelial growth factor receptor 3 binding

Gene expression in normal tissue: VEGFD

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in VEGFD

Database	Pathway ID	Pathway Des.
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-114608	Platelet degranulation
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-194138	Signaling by VEGF
reactome	R-HSA-194313	VEGF ligand-receptor interactions
reactome	R-HSA-195399	VEGF binds to VEGFR leading to receptor dimerization
reactome	R-HSA-76002	Platelet activation, signaling and aggregation
reactome	R-HSA-76005	Response to elevated platelet cytosolic Ca2+
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
wikipathways	WP306	Focal Adhesion
wikipathways	WP3932	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways	WP4172	PI3K-Akt Signaling Pathway
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
kegg	hsa04014	Ras signaling pathway - Homo sapiens (human)
kegg	hsa04015	Rap1 signaling pathway - Homo sapiens (human)
kegg	hsa04060	Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegg	hsa04151	PI3K-Akt signaling pathway - Homo sapiens (human)
kegg	hsa04510	Focal adhesion - Homo sapiens (human)
kegg	hsa04926	Relaxin signaling pathway - Homo sapiens (human)
kegg	hsa04933	AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
pid	integrin_a9b1_pathway	Alpha9 beta1 integrin signaling events
pid	lymphangiogenesis_pathway	VEGFR3 signaling in lymphatic endothelium
pid	vegf_vegfr_pathway	VEGF and VEGFR signaling network

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD307	Manumycin A	3
iGMDRD116	CD437	1
iGMDRD560	MK-2206	3
iGMDRD345	Compound 10b [PMID: 11504634]	2
iGMDRD523	Cyanoquinoline, 11	4
iGMDRD871	BRD6368	2
iGMDRD286	Nsc 632839	1
iGMDRD872	BRD7137	3
iGMDRD329	Merck60	2
iGMDRD662	JQ-1	2
iGMDRD246	NPC26	2
iGMDRD42	Vorinostat	3
iGMDRD202	Curcumin	2
iGMDRD6	AM-580	2
iGMDRD481	Dactolisib	4
iGMDRD267	Oligomycin A	4
iGMDRD61	Kinetin riboside	2
iGMDRD359	OSW-1	3
iGMDRD375	GW-405833	2
iGMDRD554	CHEMBL1434137	2
iGMDRD599	Salermide	5
iGMDRD1008	SR-II-138A	3
iGMDRD772	BRD4770	2
iGMDRD546	BMS-754807	3
iGMDRD494	Neopeltolide	2
iGMDRD781	Sirolimus	2
iGMDRD100	Zebularine	2
iGMDRD399	Selumetinib	5
iGMDRD888	Compound 44	5
iGMDRD562	Navitoclax	2
iGMDRD60	Quinoclamine	2
iGMDRD524	ISX-9	5
iGMDRD451	Serdemetan	2
iGMDRD474	Avrainvillamide	3
iGMDRD318	PAC-1	2
iGMDRD885	Compound 110	5
iGMDRD870	BRD63610	2
iGMDRD52	Rotenone	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in VEGFD

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.