VEGFD

Summary: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namevascular endothelial growth factor D
OMIM IDMIM:300091
Ensembl IDEnsembl:ENSG00000165197
HGNC IDHGNC:HGNC:3708
PHARMGKB IDPA28146
Map LocationXp22.2

GO terms in VEGFD


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005576 extracellular region
CC IBA GO:0005615 extracellular space
CC IEA GO:0016020 membrane
CC TAS GO:0031093 platelet alpha granule lumen
BP IBA GO:0001525 angiogenesis
BP IBA GO:0001666 response to hypoxia
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Gene expression in normal tissue: VEGFD

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined26PI3K/MTOR signaling2Apoptosis regulation2Biosynthesis of secondary metabolites1ERK MAPK signaling1p53 pathway1IGFR signaling1Chromatin other1Chromatin histone acetylation1Stilbenoid, diarylheptanoid and gingerol biosynthesis1

Pathways in VEGFD


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-114608 Platelet degranulation
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-194138 Signaling by VEGF
reactome R-HSA-194313 VEGF ligand-receptor interactions
reactome R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD307 Manumycin A 3
iGMDRD116 CD437 1
iGMDRD560 MK-2206 3
iGMDRD345 Compound 10b [PMID: 11504634] 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in VEGFD

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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