VEGFD


Summary: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
vascular endothelial growth factor DMIM:300091Ensembl:ENSG00000165197HGNC:HGNC:3708PA28146Xp22.2

GO terms in VEGFD


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIEAGO:0016020membrane
CCTASGO:0031093platelet alpha granule lumen
BPIBAGO:0001525angiogenesis
BPIBAGO:0001666response to hypoxia
BPIBAGO:0001934positive regulation of protein phosphorylation
BPIBAGO:0001938positive regulation of endothelial cell proliferation
BPIBAGO:0002040sprouting angiogenesis
BPTASGO:0002576platelet degranulation
BPIEAGO:0008283cell proliferation
BPTASGO:0008284positive regulation of cell proliferation
BPIEAGO:0010469regulation of signaling receptor activity
BPIBAGO:0038084vascular endothelial growth factor signaling pathway
BPIBAGO:0045766positive regulation of angiogenesis
BPIBAGO:0048010vascular endothelial growth factor receptor signaling pathway
BPTASGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIEAGO:0050918positive chemotaxis
BPIBAGO:0050930induction of positive chemotaxis
BPIDAGO:0050930induction of positive chemotaxis
BPIEAGO:0051781positive regulation of cell division
BPIBAGO:0060754positive regulation of mast cell chemotaxis
BPIDAGO:0060754positive regulation of mast cell chemotaxis
BPIEAGO:0071542dopaminergic neuron differentiation
MFTASGO:0005161platelet-derived growth factor receptor binding
MFIPIGO:0005172vascular endothelial growth factor receptor binding
MFIPIGO:0005515protein binding
MFIBAGO:0008083growth factor activity
MFIBAGO:0042056chemoattractant activity
MFIDAGO:0042056chemoattractant activity
MFIEAGO:0042803protein homodimerization activity
MFIBAGO:0043185vascular endothelial growth factor receptor 3 binding

Gene expression in normal tissue: VEGFD

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in VEGFD


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-114608Platelet degranulation
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-194313VEGF ligand-receptor interactions
reactomeR-HSA-195399VEGF binds to VEGFR leading to receptor dimerization
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76005Response to elevated platelet cytosolic Ca2+
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
pidintegrin_a9b1_pathwayAlpha9 beta1 integrin signaling events
pidlymphangiogenesis_pathwayVEGFR3 signaling in lymphatic endothelium
pidvegf_vegfr_pathwayVEGF and VEGFR signaling network

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD307Manumycin A3
iGMDRD116CD4371
iGMDRD560MK-22063
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD523Cyanoquinoline, 114
iGMDRD871BRD63682
iGMDRD286Nsc 6328391
iGMDRD872BRD71373
iGMDRD329Merck602
iGMDRD662JQ-12
iGMDRD246NPC262
iGMDRD42Vorinostat3
iGMDRD202Curcumin2
iGMDRD6AM-5802
iGMDRD481Dactolisib4
iGMDRD267Oligomycin A4
iGMDRD61Kinetin riboside2
iGMDRD359OSW-13
iGMDRD375GW-4058332
iGMDRD554CHEMBL14341372
iGMDRD599Salermide5
iGMDRD1008SR-II-138A3
iGMDRD772BRD47702
iGMDRD546BMS-7548073
iGMDRD494Neopeltolide2
iGMDRD781Sirolimus2
iGMDRD100Zebularine2
iGMDRD399Selumetinib5
iGMDRD888Compound 445
iGMDRD562Navitoclax2
iGMDRD60Quinoclamine2
iGMDRD524ISX-95
iGMDRD451Serdemetan2
iGMDRD474Avrainvillamide3
iGMDRD318PAC-12
iGMDRD885Compound 1105
iGMDRD870BRD636102
iGMDRD52Rotenone2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in VEGFD

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