CCNT1


Summary: This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:143055
PHARMGKB IDPA26163
Map Location12q13.11-q13.12

GO terms in CCNT1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0000307 cyclin-dependent protein kinase holoenzyme complex
CC IBA GO:0005634 nucleus
CC IDA GO:0005634 nucleus
CC IDA GO:0005654 nucleoplasm
CC TAS GO:0005654 nucleoplasm
CC IDA GO:0005730 nucleolus
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Gene expression in normal tissue: CCNT1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CCNT1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-112382 Formation of RNA Pol II elongation complex
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-162587 HIV Life Cycle
reactome R-HSA-162587 HIV Life Cycle
reactome R-HSA-162599 Late Phase of HIV Life Cycle
reactome R-HSA-162599 Late Phase of HIV Life Cycle
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD60 Quinoclamine 2
iGMDRD886 Compound 1541A 3
iGMDRD887 Compound 23 citrate 3
iGMDRD100 Zebularine 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCNT1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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