SKP2


Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
S-phase kinase associated protein 2MIM:601436Ensembl:ENSG00000145604HGNC:HGNC:10901PA358015p13.2

Gene Categories:

TUMOR SUPPRESSOR

GO terms in SKP2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0000082G1/S transition of mitotic cell cycle
BPIBAGO:0000086G2/M transition of mitotic cell cycle
BPIEAGO:0000086G2/M transition of mitotic cell cycle
BPTASGO:0000209protein polyubiquitination
BPIEAGO:0006511ubiquitin-dependent protein catabolic process
BPTASGO:0008283cell proliferation
BPTASGO:0016579protein deubiquitination
BPIBAGO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
BPIEAGO:0033148positive regulation of intracellular estrogen receptor signaling pathway
BPIDAGO:0042981regulation of apoptotic process
BPTASGO:0043687post-translational protein modification
BPIEAGO:0048661positive regulation of smooth muscle cell proliferation
BPIBAGO:0051726regulation of cell cycle
BPIEAGO:0051726regulation of cell cycle
BPIEAGO:0071460cellular response to cell-matrix adhesion
BPIEAGO:1902916positive regulation of protein polyubiquitination
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIBAGO:0019005SCF ubiquitin ligase complex
CCIDAGO:0019005SCF ubiquitin ligase complex
MFEXPGO:0004842ubiquitin-protein transferase activity
MFTASGO:0004842ubiquitin-protein transferase activity
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
MFIBAGO:0061630ubiquitin protein ligase activity
MFIEAGO:0061630ubiquitin protein ligase activity

Gene expression in normal tissue: SKP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SKP2


DatabasePathway IDPathway Des.
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
pidfoxm1pathwayFOXM1 transcription factor network
pidfoxopathwayFoxO family signaling
pidmyc_pathwayC-MYC pathway
pidnotch_pathwayNotch signaling pathway
pidp53regulationpathwayp53 pathway
pidrb_1pathwayRegulation of retinoblastoma protein
netpathPathway_NotchNotch
wikipathwaysWP179Cell Cycle
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP3640Imatinib and Chronic Myeloid Leukemia
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-168256Immune System
reactomeR-HSA-174143APC/C-mediated degradation of cell cycle proteins
reactomeR-HSA-174178APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
reactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-453276Regulation of mitotic cell cycle
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-68949Orc1 removal from chromatin
reactomeR-HSA-69052Switching of origins to a post-replicative state
reactomeR-HSA-69202Cyclin E associated events during G1/S transition
reactomeR-HSA-69206G1/S Transition
reactomeR-HSA-69231Cyclin D associated events in G1
reactomeR-HSA-69236G1 Phase
reactomeR-HSA-69239Synthesis of DNA
reactomeR-HSA-69242S Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-69306DNA Replication
reactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entry
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878166Transcriptional regulation by RUNX2
reactomeR-HSA-8939902Regulation of RUNX2 expression and activity
reactomeR-HSA-8951664Neddylation
reactomeR-HSA-983168Antigen processing: Ubiquitination & Proteasome degradation
reactomeR-HSA-983169Class I MHC mediated antigen processing & presentation
biocartap27pathwayregulation of p27 phosphorylation during cell cycle progression
biocartaskp2e2fpathwaye2f1 destruction pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD483SCH-5290741
iGMDRD231Importazole2
iGMDRD116CD4372
iGMDRD427ABT7373
iGMDRD387CHIR-990211
iGMDRD126Tipifarnib3
iGMDRD474Avrainvillamide3
iGMDRD210AC556493
iGMDRD886Compound 1541A6
iGMDRD280CYTOCHALASIN B3
iGMDRD577BIX012943
iGMDRD399Selumetinib3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SKP2

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