CDC7
Summary: This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:603311 Ensembl IDEnsembl:ENSG00000097046 HGNC IDHGNC:HGNC:1745 PHARMGKB IDPA26272 Map Location1p22.1 | |||||
GO terms in CDC7
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016301 | kinase activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: CDC7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDC7
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP466 | DNA Replication |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-176187 | Activation of ATR in response to replication stress |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDC7
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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