CDC7
Summary: This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cell division cycle 7 | MIM:603311 | Ensembl:ENSG00000097046 | HGNC:HGNC:1745 | PA26272 | 1p22.1 |
GO terms in CDC7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016301 | kinase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0045171 | intercellular bridge |
| CC | IDA | GO:0072686 | mitotic spindle |
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IBA | GO:0000727 | double-strand break repair via break-induced replication |
| BP | TAS | GO:0006260 | DNA replication |
| BP | IBA | GO:0006270 | DNA replication initiation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0010571 | positive regulation of nuclear cell cycle DNA replication |
| BP | IMP | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IMP | GO:0044770 | cell cycle phase transition |
| BP | IEA | GO:0051301 | cell division |
| BP | TAS | GO:0070317 | negative regulation of G0 to G1 transition |
Gene expression in normal tissue: CDC7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDC7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP466 | DNA Replication |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-176187 | Activation of ATR in response to replication stress |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-68874 | M/G1 Transition |
| reactome | R-HSA-68962 | Activation of the pre-replicative complex |
| reactome | R-HSA-69002 | DNA Replication Pre-Initiation |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953750 | Transcriptional Regulation by E2F6 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD150 | RITA | 5 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD415 | LE-135 | 2 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD505 | Pevonedistat | 5 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDC7
CLASSFICATION
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