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CYP17A1

Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
cytochrome P450 family 17 subfamily A member 1	MIM:609300	Ensembl:ENSG00000148795	HGNC:HGNC:2593	PA27090	10q24.32

Gene Categories:

CYTOCHROME P450 DRUGGABLE GENOME

GO terms in CYP17A1

Term Type	Evidence Type	GO Term ID	GO Des.
CC	NAS	GO:0005783	endoplasmic reticulum
CC	TAS	GO:0005789	endoplasmic reticulum membrane
CC	IEA	GO:0030424	axon
CC	IEA	GO:0043025	neuronal cell body
BP	TAS	GO:0006694	steroid biosynthetic process
BP	TAS	GO:0006702	androgen biosynthetic process
BP	TAS	GO:0006704	glucocorticoid biosynthetic process
BP	TAS	GO:0007548	sex differentiation
BP	IDA	GO:0008202	steroid metabolic process
BP	TAS	GO:0016125	sterol metabolic process
BP	IBA	GO:0042446	hormone biosynthetic process
BP	IDA	GO:0042446	hormone biosynthetic process
BP	IBA	GO:0042448	progesterone metabolic process
BP	IDA	GO:0042448	progesterone metabolic process
BP	IEA	GO:0055114	oxidation-reduction process
MF	IBA	GO:0004508	steroid 17-alpha-monooxygenase activity
MF	IDA	GO:0004508	steroid 17-alpha-monooxygenase activity
MF	IMP	GO:0004508	steroid 17-alpha-monooxygenase activity
MF	TAS	GO:0004508	steroid 17-alpha-monooxygenase activity
MF	IEA	GO:0005506	iron ion binding
MF	TAS	GO:0019825	oxygen binding
MF	IDA	GO:0020037	heme binding
MF	IBA	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity
MF	IMP	GO:0047442	17-alpha-hydroxyprogesterone aldolase activity

Gene expression in normal tissue: CYP17A1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CYP17A1

Database	Pathway ID	Pathway Des.
smpdb	SMP00068	Androgen and Estrogen Metabolism
smpdb	SMP00130	Steroidogenesis
smpdb	SMP00356	17-Beta Hydroxysteroid Dehydrogenase III Deficiency
smpdb	SMP00371	Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH
smpdb	SMP00372	Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia due to 17 Alpha-hydroxylase Deficiency
smpdb	SMP00373	Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia due to 21-hydroxylase Deficiency
smpdb	SMP00565	Aromatase deficiency
smpdb	SMP00566	17-alpha-hydroxylase deficiency (CYP17)
smpdb	SMP00575	11-beta-hydroxylase deficiency (CYP11B1)
smpdb	SMP00576	21-hydroxylase deficiency (CYP21)
smpdb	SMP00577	Corticosterone methyl oxidase I deficiency (CMO I)
smpdb	SMP00578	Corticosterone methyl oxidase II deficiency - CMO II
smpdb	SMP00717	Apparent mineralocorticoid excess syndrome
smpdb	SMP00718	3-Beta-Hydroxysteroid Dehydrogenase Deficiency
wikipathways	WP2263	Androgen Receptor Network in Prostate Cancer
wikipathways	WP237	Glucocorticoid and Mineralcorticoid Metabolism
wikipathways	WP43	Oxidation by Cytochrome P450
wikipathways	WP496	Steroid Biosynthesis
wikipathways	WP702	Metapathway biotransformation Phase I and II
kegg	hsa00140	Steroid hormone biosynthesis - Homo sapiens (human)
kegg	hsa04913	Ovarian steroidogenesis - Homo sapiens (human)
kegg	hsa04917	Prolactin signaling pathway - Homo sapiens (human)
kegg	hsa04927	Cortisol synthesis and secretion - Homo sapiens (human)
kegg	hsa04934	Cushing,s syndrome - Homo sapiens (human)
humancyc	PWY-7305	superpathway of steroid hormone biosynthesis
humancyc	PWY66-378	androgen biosynthesis
humancyc	PWY66-381	glucocorticoid biosynthesis
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-1643685	Disease
reactome	R-HSA-193048	Androgen biosynthesis
reactome	R-HSA-194002	Glucocorticoid biosynthesis
reactome	R-HSA-196071	Metabolism of steroid hormones
reactome	R-HSA-211859	Biological oxidations
reactome	R-HSA-211897	Cytochrome P450 - arranged by substrate type
reactome	R-HSA-211945	Phase I - Functionalization of compounds
reactome	R-HSA-211976	Endogenous sterols
reactome	R-HSA-556833	Metabolism of lipids
reactome	R-HSA-5579028	Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
reactome	R-HSA-5579029	Metabolic disorders of biological oxidation enzymes
reactome	R-HSA-5668914	Diseases of metabolism
reactome	R-HSA-8957322	Metabolism of steroids

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD886	Compound 1541A	3
iGMDRD263	AACOCF3	3
iGMDRD414	MST-312	8
iGMDRD286	Nsc 632839	6
iGMDRD289	Parthenolide	2
iGMDRD105	Triptolide	2
iGMDRD434	BMS-536924	2
iGMDRD114	Abiraterone	1
iGMDRD103	SN-38	3
iGMDRD251	ML162	3
iGMDRD121	GMX1778	2
iGMDRD177	Teniposide	3
iGMDRD945	ML214	4
iGMDRD341	Triacsin c	1
iGMDRD219	Bax channel blocker	2
iGMDRD116	CD437	3
iGMDRD268	Cerulenin	1
iGMDRD23	Gossypol	5
iGMDRD188	Piperlongumine	4
iGMDRD887	Compound 23 citrate	2
iGMDRD577	BIX01294	2
iGMDRD562	Navitoclax	7
iGMDRD780	PP-30	2
iGMDRD782	DC-45-A2	6
iGMDRD318	PAC-1	3
iGMDRD870	BRD63610	1
iGMDRD138	PX 12	1
iGMDRD474	Avrainvillamide	3
iGMDRD255	SB225002	3
iGMDRD487	Enzalutamide	1
iGMDRD297	Austocystin D	4
iGMDRD466	Chaetocin	1
iGMDRD634	SCHEMBL2608041	2
iGMDRD446	LY 2183240	2
iGMDRD61	Kinetin riboside	4
iGMDRD152	179324-69-7	5
iGMDRD144	NSC95397	4
iGMDRD427	ABT737	1
iGMDRD126	Tipifarnib	2
iGMDRD420	Leucascandrolide A	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CYP17A1

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DATATYPES

CLASSFICATION

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