CYP17A1

Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. It has both 17alpha-hydroxylase and 17,20-lyase activities and is a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecytochrome P450 family 17 subfamily A member 1
OMIM IDMIM:609300
Ensembl IDEnsembl:ENSG00000148795
HGNC IDHGNC:HGNC:2593
PHARMGKB IDPA27090
Map Location10q24.32

GO terms in CYP17A1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
CC NAS GO:0005783 endoplasmic reticulum
CC TAS GO:0005789 endoplasmic reticulum membrane
CC IEA GO:0030424 axon
CC IEA GO:0043025 neuronal cell body
BP TAS GO:0006694 steroid biosynthetic process
BP TAS GO:0006702 androgen biosynthetic process
Showing 1 to 6 of 24 rows rows per page

Gene expression in normal tissue: CYP17A1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 34undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 60undefinedtissue: undefined cancer: NON_SMALL_CELL_CARCINOMA model num: 9BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 10UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 1PROSTATtissue: PROSTAT cancer: PROSTATE model num: 0PROSTATEtissue: PROSTATE cancer: Prostate Adenocarcinoma (PRAD) model num: 2

Gene-drug pathway distribution

undefined34Apoptosis regulation2Proteasome1DNA replication1Chromatin histone acetylation1Biosynthesis of secondary metabolites1

Pathways in CYP17A1


Loading, please wait...
Database
Pathway ID
Pathway Des.
smpdb SMP00068 Androgen and Estrogen Metabolism
smpdb SMP00130 Steroidogenesis
smpdb SMP00356 17-Beta Hydroxysteroid Dehydrogenase III Deficiency
smpdb SMP00371 Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH
smpdb SMP00372 Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia due to 17 Alpha-hydroxylase Deficiency
smpdb SMP00373 Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia due to 21-hydroxylase Deficiency
Showing 1 to 6 of 41 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD886 Compound 1541A 3
iGMDRD263 AACOCF3 3
iGMDRD414 MST-312 8
iGMDRD286 Nsc 632839 6
Showing 1 to 4 of 40 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CYP17A1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.