CHD6
Summary: This gene encodes a member of the SNF2/RAD54 helicase protein family. The encoded protein contains two chromodomains, a helicase domain, and an ATPase domain. Several multi-subunit protein complexes remodel chromatin to allow patterns of cell type-specific gene expression, and the encoded protein is thought to be a core member of one or more of these chromatin remodeling complexes. The encoded protein may function as a transcriptional repressor and is involved in the cellular repression of influenza virus replication. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| chromodomain helicase DNA binding protein 6 | MIM:616114 | Ensembl:ENSG00000124177 | HGNC:HGNC:19057 | PA134974700 | 20q12 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in CHD6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0001221 | transcription cofactor binding |
| MF | IEA | GO:0003677 | DNA binding |
| MF | IEA | GO:0004386 | helicase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0008094 | DNA-dependent ATPase activity |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005665 | DNA-directed RNA polymerase II, core complex |
| BP | IEA | GO:0006325 | chromatin organization |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0016032 | viral process |
| BP | IMP | GO:0036091 | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress |
Gene expression in normal tissue: CHD6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHD6
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD150 | RITA | 5 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD251 | ML162 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD271 | Brefeldin A | 4 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD289 | Parthenolide | 7 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD505 | Pevonedistat | 8 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD462 | OSI-906 (Linsitinib) | 2 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD670 | ML 210 | 1 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD427 | ABT737 | 4 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD870 | BRD63610 | 4 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD444 | Tivantinib | 3 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD690 | PRIMA-1MET | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHD6
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