CXCR2
Summary: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| C-X-C motif chemokine receptor 2 | MIM:146928 | Ensembl:ENSG00000180871 | HGNC:HGNC:6027 | PA29843 | 2q35 |
GO terms in CXCR2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004918 | interleukin-8 receptor activity |
| MF | IDA | GO:0004930 | G-protein coupled receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016493 | C-C chemokine receptor activity |
| MF | IDA | GO:0016494 | C-X-C chemokine receptor activity |
| MF | IBA | GO:0019956 | chemokine binding |
| MF | IBA | GO:0019957 | C-C chemokine binding |
| MF | IPI | GO:0019959 | interleukin-8 binding |
| CC | IDA | GO:0005622 | intracellular |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | IDA | GO:0009986 | cell surface |
| CC | IDA | GO:0016020 | membrane |
| CC | TAS | GO:0030667 | secretory granule membrane |
| CC | IDA | GO:0042629 | mast cell granule |
| BP | TAS | GO:0002407 | dendritic cell chemotaxis |
| BP | IEA | GO:0002438 | acute inflammatory response to antigenic stimulus |
| BP | IBA | GO:0006935 | chemotaxis |
| BP | IDA | GO:0006935 | chemotaxis |
| BP | TAS | GO:0006954 | inflammatory response |
| BP | IBA | GO:0006955 | immune response |
| BP | IDA | GO:0006968 | cellular defense response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IDA | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IDA | GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | IEA | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0010666 | positive regulation of cardiac muscle cell apoptotic process |
| BP | IBA | GO:0019722 | calcium-mediated signaling |
| BP | IBA | GO:0030593 | neutrophil chemotaxis |
| BP | IDA | GO:0030593 | neutrophil chemotaxis |
| BP | IEA | GO:0030901 | midbrain development |
| BP | IDA | GO:0031623 | receptor internalization |
| BP | IEA | GO:0033030 | negative regulation of neutrophil apoptotic process |
| BP | IDA | GO:0038112 | interleukin-8-mediated signaling pathway |
| BP | IDA | GO:0042119 | neutrophil activation |
| BP | IEA | GO:0043117 | positive regulation of vascular permeability |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0045766 | positive regulation of angiogenesis |
| BP | IBA | GO:0060326 | cell chemotaxis |
| BP | IEA | GO:0070098 | chemokine-mediated signaling pathway |
| BP | IEA | GO:0072173 | metanephric tubule morphogenesis |
| BP | IEA | GO:0090023 | positive regulation of neutrophil chemotaxis |
Gene expression in normal tissue: CXCR2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CXCR2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375276 | Peptide ligand-binding receptors |
| reactome | R-HSA-380108 | Chemokine receptors bind chemokines |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-500792 | GPCR ligand binding |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| pid | il8cxcr2_pathway | IL8- and CXCR2-mediated signaling events |
| wikipathways | WP117 | GPCRs, Other |
| wikipathways | WP24 | Peptide GPCRs |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP455 | GPCRs, Class A Rhodopsin-like |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD150 | RITA | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD2 | PK-11195 | 1 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD474 | Avrainvillamide | 6 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD782 | DC-45-A2 | 6 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD42 | Vorinostat | 7 |
| iGMDRD300 | Tozasertib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CXCR2
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.