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FN1

Summary: This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. The encoded preproprotein is proteolytically processed to generate the mature protein. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants, at least one of which encodes an isoform that undergoes proteolytic processing. The full-length nature of some variants has not been determined. [provided by RefSeq, Jan 2016].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namefibronectin 1 OMIM IDMIM:135600 Ensembl IDEnsembl:ENSG00000115414 HGNC IDHGNC:HGNC:3778 PHARMGKB IDPA28194 Map Location2q35

Gene Categories:

PROTEASE DRUGGABLE GENOME

GO terms in FN1

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	HDA	GO:0005576	extracellular region
CC	NAS	GO:0005576	extracellular region
CC	TAS	GO:0005576	extracellular region
CC	IDA	GO:0005577	fibrinogen complex
CC	HDA	GO:0005615	extracellular space
CC	IDA	GO:0005615	extracellular space

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Gene expression in normal tissue: FN1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FN1

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-114608	Platelet degranulation
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-1474228	Degradation of the extracellular matrix
reactome	R-HSA-1474228	Degradation of the extracellular matrix
reactome	R-HSA-1474244	Extracellular matrix organization

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD690	PRIMA-1MET	3
iGMDRD60	Quinoclamine	3
iGMDRD369	TGX-115	3
iGMDRD64	Parbendazole	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FN1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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