MMP1


Summary: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
matrix metallopeptidase 1MIM:120353Ensembl:ENSG00000196611HGNC:HGNC:7155PA3086711q22.2

GO terms in MMP1


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0006508proteolysis
BPIEAGO:0016032viral process
BPTASGO:0019221cytokine-mediated signaling pathway
BPTASGO:0022617extracellular matrix disassembly
BPTASGO:0030574collagen catabolic process
BPIDAGO:0032461positive regulation of protein oligomerization
BPTASGO:0044267cellular protein metabolic process
BPTASGO:0050900leukocyte migration
CCTASGO:0005576extracellular region
CCIEAGO:0031012extracellular matrix
MFIDAGO:0004175endopeptidase activity
MFIDAGO:0004222metalloendopeptidase activity
MFTASGO:0004222metalloendopeptidase activity
MFTASGO:0004252serine-type endopeptidase activity
MFIEAGO:0008270zinc ion binding

Gene expression in normal tissue: MMP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MMP1


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1442490Collagen degradation
reactomeR-HSA-1442490Collagen degradation
reactomeR-HSA-1474228Degradation of the extracellular matrix
reactomeR-HSA-1474228Degradation of the extracellular matrix
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1592389Activation of Matrix Metalloproteinases
reactomeR-HSA-168256Immune System
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-210991Basigin interactions
reactomeR-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
kegghsa03320PPAR signaling pathway - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
pidajdiss_2pathwayPosttranslational regulation of adherens junction stability and dissassembly
pidap1_pathwayAP-1 transcription factor network
pidendothelinpathwayEndothelins
pidfra_pathwayValidated transcriptional targets of AP1 family members Fra1 and Fra2
pidp75ntrpathwayp75(NTR)-mediated signaling
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidsyndecan_1_pathwaySyndecan-1-mediated signaling events
pidupa_upar_pathwayUrokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
wikipathwaysWP129Matrix Metalloproteinases
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2435Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis
wikipathwaysWP2828Bladder Cancer
wikipathwaysWP3617Photodynamic therapy-induced NF-kB survival signaling
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3942PPAR signaling pathway
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP4066Interleukin-4 and 13 signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD211(1S,3R)-RSL32
iGMDRD280CYTOCHALASIN B1
iGMDRD414MST-3123
iGMDRD871BRD63682
iGMDRD577BIX012946
iGMDRD314Tanespimycin1
iGMDRD150RITA1
iGMDRD427ABT7373
iGMDRD8012,4-dideoxy-DC-45-A21
iGMDRD441TW 373
iGMDRD84Lovastatin acid3
iGMDRD474Avrainvillamide3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MMP1

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