MMP1
Summary: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| matrix metallopeptidase 1 | MIM:120353 | Ensembl:ENSG00000196611 | HGNC:HGNC:7155 | PA30867 | 11q22.2 |
GO terms in MMP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0006508 | proteolysis |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | TAS | GO:0022617 | extracellular matrix disassembly |
| BP | TAS | GO:0030574 | collagen catabolic process |
| BP | IDA | GO:0032461 | positive regulation of protein oligomerization |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | TAS | GO:0050900 | leukocyte migration |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IEA | GO:0031012 | extracellular matrix |
| MF | IDA | GO:0004175 | endopeptidase activity |
| MF | IDA | GO:0004222 | metalloendopeptidase activity |
| MF | TAS | GO:0004222 | metalloendopeptidase activity |
| MF | TAS | GO:0004252 | serine-type endopeptidase activity |
| MF | IEA | GO:0008270 | zinc ion binding |
Gene expression in normal tissue: MMP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MMP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1442490 | Collagen degradation |
| reactome | R-HSA-1442490 | Collagen degradation |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1592389 | Activation of Matrix Metalloproteinases |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210991 | Basigin interactions |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05219 | Bladder cancer - Homo sapiens (human) |
| kegg | hsa05323 | Rheumatoid arthritis - Homo sapiens (human) |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | endothelinpathway | Endothelins |
| pid | fra_pathway | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | syndecan_1_pathway | Syndecan-1-mediated signaling events |
| pid | upa_upar_pathway | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| wikipathways | WP129 | Matrix Metalloproteinases |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2435 | Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis |
| wikipathways | WP2828 | Bladder Cancer |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3942 | PPAR signaling pathway |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD150 | RITA | 1 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 1 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MMP1
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