ADAM29
Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is highly expressed in testis and may be involved in human spermatogenesis. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ADAM metallopeptidase domain 29 | MIM:604778 | Ensembl:ENSG00000168594 | HGNC:HGNC:207 | PA24524 | 4q34.1 |
GO terms in ADAM29
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006508 | proteolysis |
| BP | TAS | GO:0007283 | spermatogenesis |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| MF | IEA | GO:0004222 | metalloendopeptidase activity |
| MF | TAS | GO:0008237 | metallopeptidase activity |
Gene expression in normal tissue: ADAM29
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADAM29
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD269 | Purmorphamine | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD103 | SN-38 | 1 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD121 | GMX1778 | 5 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD150 | RITA | 4 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD607 | Ubistatin B | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD730 | Kahalalide F | 2 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD255 | SB225002 | 5 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD163 | all trans Retinoic Acid | 2 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD483 | SCH-529074 | 4 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD420 | Leucascandrolide A | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADAM29
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.