BCL11B
Summary: This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| B cell CLL/lymphoma 11B | MIM:606558 | Ensembl:ENSG00000127152 | HGNC:HGNC:13222 | PA25301 | 14q32.2 |
GO terms in BCL11B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IEA | GO:0043005 | neuron projection |
| BP | IEA | GO:0003334 | keratinocyte development |
| BP | IEA | GO:0003382 | epithelial cell morphogenesis |
| BP | IBA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0010837 | regulation of keratinocyte proliferation |
| BP | IEA | GO:0019216 | regulation of lipid metabolic process |
| BP | IEA | GO:0021773 | striatal medium spiny neuron differentiation |
| BP | IEA | GO:0021902 | commitment of neuronal cell to specific neuron type in forebrain |
| BP | IEA | GO:0031077 | post-embryonic camera-type eye development |
| BP | IEA | GO:0033077 | T cell differentiation in thymus |
| BP | IEA | GO:0033153 | T cell receptor V(D)J recombination |
| BP | IMP | GO:0035701 | hematopoietic stem cell migration |
| BP | IEA | GO:0042475 | odontogenesis of dentin-containing tooth |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043368 | positive T cell selection |
| BP | IEA | GO:0045664 | regulation of neuron differentiation |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0046632 | alpha-beta T cell differentiation |
| BP | IEA | GO:0048538 | thymus development |
| BP | IEA | GO:0071678 | olfactory bulb axon guidance |
| BP | IMP | GO:0097535 | lymphoid lineage cell migration into thymus |
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0043565 | sequence-specific DNA binding |
| MF | IBA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: BCL11B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BCL11B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3893 | Development and heterogeneity of the ILC family |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD520 | Pictilisib | 1 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD698 | Neratinib | 5 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD901 | ELCPK | 4 |
| iGMDRD883 | CIL55A | 4 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD871 | BRD6368 | 4 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD263 | AACOCF3 | 4 |
| iGMDRD300 | Tozasertib | 8 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD144 | NSC95397 | 9 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD152 | 179324-69-7 | 7 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD255 | SB225002 | 5 |
| iGMDRD568 | SCHEMBL15005512 | 1 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD260 | FQI-2 | 4 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD885 | Compound 110 | 4 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD780 | PP-30 | 6 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD64 | Parbendazole | 5 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD874 | BRD8958 | 1 |
| iGMDRD23 | Gossypol | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BCL11B
CLASSFICATION
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