BCL11B


Summary: This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
B cell CLL/lymphoma 11BMIM:606558Ensembl:ENSG00000127152HGNC:HGNC:13222PA2530114q32.2

GO terms in BCL11B


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005634nucleus
CCIEAGO:0043005neuron projection
BPIEAGO:0003334keratinocyte development
BPIEAGO:0003382epithelial cell morphogenesis
BPIBAGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006366transcription by RNA polymerase II
BPIBAGO:0007275multicellular organism development
BPIEAGO:0008285negative regulation of cell proliferation
BPIEAGO:0010837regulation of keratinocyte proliferation
BPIEAGO:0019216regulation of lipid metabolic process
BPIEAGO:0021773striatal medium spiny neuron differentiation
BPIEAGO:0021902commitment of neuronal cell to specific neuron type in forebrain
BPIEAGO:0031077post-embryonic camera-type eye development
BPIEAGO:0033077T cell differentiation in thymus
BPIEAGO:0033153T cell receptor V(D)J recombination
BPIMPGO:0035701hematopoietic stem cell migration
BPIEAGO:0042475odontogenesis of dentin-containing tooth
BPIEAGO:0043066negative regulation of apoptotic process
BPIEAGO:0043368positive T cell selection
BPIEAGO:0045664regulation of neuron differentiation
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046632alpha-beta T cell differentiation
BPIEAGO:0048538thymus development
BPIEAGO:0071678olfactory bulb axon guidance
BPIMPGO:0097535lymphoid lineage cell migration into thymus
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIBAGO:0043565sequence-specific DNA binding
MFIBAGO:0044212transcription regulatory region DNA binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: BCL11B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BCL11B


DatabasePathway IDPathway Des.
wikipathwaysWP3893Development and heterogeneity of the ILC family
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD486Tosedostat1
iGMDRD512nutlin 32
iGMDRD584VER 1550082
iGMDRD424Tamatinib3
iGMDRD520Pictilisib1
iGMDRD79Gemcitabine3
iGMDRD701NVP-AUY9222
iGMDRD536PLX-47201
iGMDRD698Neratinib5
iGMDRD57Chloropentafluorobenzene2
iGMDRD123Isoevodiamine4
iGMDRD901ELCPK4
iGMDRD883CIL55A4
iGMDRD945ML2146
iGMDRD154NSC237664
iGMDRD202Curcumin3
iGMDRD121GMX17781
iGMDRD434BMS-5369242
iGMDRD105Triptolide1
iGMDRD289Parthenolide5
iGMDRD481Dactolisib2
iGMDRD871BRD63684
iGMDRD414MST-3123
iGMDRD366PI-1032
iGMDRD329Merck603
iGMDRD263AACOCF34
iGMDRD300Tozasertib8
iGMDRD151CHM-14
iGMDRD126Tipifarnib4
iGMDRD579PF7502
iGMDRD546BMS-7548072
iGMDRD144NSC953979
iGMDRD494Neopeltolide4
iGMDRD446LY 21832402
iGMDRD152179324-69-77
iGMDRD61Kinetin riboside1
iGMDRD193Fqi14
iGMDRD280CYTOCHALASIN B4
iGMDRD466Chaetocin1
iGMDRD138PX 123
iGMDRD474Avrainvillamide3
iGMDRD255SB2250025
iGMDRD568SCHEMBL150055121
iGMDRD8024-methylfasudil2
iGMDRD260FQI-24
iGMDRD870BRD636103
iGMDRD187BRD98762
iGMDRD885Compound 1104
iGMDRD399Selumetinib1
iGMDRD188Piperlongumine6
iGMDRD780PP-306
iGMDRD577BIX012945
iGMDRD506Fedratinib3
iGMDRD369TGX-1153
iGMDRD64Parbendazole5
iGMDRD356PNU-746541
iGMDRD874BRD89581
iGMDRD23Gossypol2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BCL11B

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