HERC2
Summary: This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| HECT and RLD domain containing E3 ubiquitin protein ligase 2 | MIM:605837 | Ensembl:ENSG00000128731 | HGNC:HGNC:4868 | PA29243 | 15q13.1 |
Gene Categories:
DNA REPAIRGO terms in HERC2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | NAS | GO:0005085 | guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IDA | GO:0032183 | SUMO binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005814 | centriole |
| CC | HDA | GO:0016020 | membrane |
| BP | TAS | GO:0006303 | double-strand break repair via nonhomologous end joining |
| BP | NAS | GO:0006886 | intracellular protein transport |
| BP | IBA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IDA | GO:0016567 | protein ubiquitination |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | IBA | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
Gene expression in normal tissue: HERC2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HERC2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| wikipathways | WP3998 | Prader-Willi and Angelman Syndrome |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108214 | SUMOylation of DNA damage response and repair proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) |
| reactome | R-HSA-5693606 | DNA Double Strand Break Response |
| reactome | R-HSA-5693607 | Processing of DNA double-strand break ends |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-69473 | G2/M DNA damage checkpoint |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-983168 | Antigen processing: Ubiquitination & Proteasome degradation |
| reactome | R-HSA-983169 | Class I MHC mediated antigen processing & presentation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD427 | ABT737 | 2 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD126 | Tipifarnib | 7 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD420 | Leucascandrolide A | 5 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD23 | Gossypol | 4 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD74 | Idarubicin | 6 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD237 | ABT-751 | 5 |
| iGMDRD213 | SMR000068650 | 1 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD121 | GMX1778 | 7 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD322 | FK 866 | 6 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD486 | Tosedostat | 2 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD351 | GW843682X | 6 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD415 | LE-135 | 2 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD872 | BRD7137 | 12 |
| iGMDRD882 | CIL41 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HERC2
CLASSFICATION
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