RGL2
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ral guanine nucleotide dissociation stimulator like 2 | MIM:602306 | Ensembl:ENSG00000237441 | HGNC:HGNC:9769 | PA34120 | 6p21.32 |
GO terms in RGL2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IEA | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| CC | ND | GO:0005575 | cellular_component |
| CC | IEA | GO:0005622 | intracellular |
| BP | NAS | GO:0007265 | Ras protein signal transduction |
| BP | IEA | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process |
| BP | IEA | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| BP | IEA | GO:0032485 | regulation of Ral protein signal transduction |
Gene expression in normal tissue: RGL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RGL2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4223 | Ras Signaling |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD882 | CIL41 | 2 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD314 | Tanespimycin | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD148 | Pifithrin-mu | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD424 | Tamatinib | 5 |
| iGMDRD150 | RITA | 2 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD885 | Compound 110 | 1 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD61 | Kinetin riboside | 8 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD425 | ERASTIN | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD546 | BMS-754807 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RGL2
CLASSFICATION
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