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RPTOR

Summary: This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
regulatory associated protein of MTOR complex 1	MIM:607130	Ensembl:ENSG00000141564	HGNC:HGNC:30287	PA165432629	17q25.3

Gene Categories:

TYROSINE KINASE SERINE THREONINE KINASE TRANSCRIPTION FACTOR BINDING TUMOR SUPPRESSOR KINASE CLINICALLY ACTIONABLE

GO terms in RPTOR

Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0005654	nucleoplasm
CC	TAS	GO:0005654	nucleoplasm
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005764	lysosome
CC	IMP	GO:0005764	lysosome
CC	HDA	GO:0005765	lysosomal membrane
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0010494	cytoplasmic stress granule
CC	IEA	GO:0030425	dendrite
CC	IBA	GO:0031931	TORC1 complex
CC	IDA	GO:0031931	TORC1 complex
CC	IEA	GO:0043025	neuronal cell body
BP	IMP	GO:0001558	regulation of cell growth
BP	IEA	GO:0001938	positive regulation of endothelial cell proliferation
BP	TAS	GO:0007050	cell cycle arrest
BP	IBA	GO:0008361	regulation of cell size
BP	IMP	GO:0008361	regulation of cell size
BP	IBA	GO:0009267	cellular response to starvation
BP	IBA	GO:0010506	regulation of autophagy
BP	IMP	GO:0010800	positive regulation of peptidyl-threonine phosphorylation
BP	TAS	GO:0016241	regulation of macroautophagy
BP	IBA	GO:0030307	positive regulation of cell growth
BP	IMP	GO:0030307	positive regulation of cell growth
BP	IMP	GO:0031669	cellular response to nutrient levels
BP	IBA	GO:0031929	TOR signaling
BP	IDA	GO:0031929	TOR signaling
BP	IDA	GO:0032008	positive regulation of TOR signaling
BP	IEA	GO:0032147	activation of protein kinase activity
BP	IMP	GO:0033138	positive regulation of peptidyl-serine phosphorylation
BP	IMP	GO:0038202	TORC1 signaling
BP	IMP	GO:0045945	positive regulation of transcription by RNA polymerase III
BP	IBA	GO:0071230	cellular response to amino acid stimulus
BP	IMP	GO:0071230	cellular response to amino acid stimulus
BP	IDA	GO:0071233	cellular response to leucine
BP	IEA	GO:0071901	negative regulation of protein serine/threonine kinase activity
BP	IBA	GO:0071902	positive regulation of protein serine/threonine kinase activity
BP	IDA	GO:0071902	positive regulation of protein serine/threonine kinase activity
BP	TAS	GO:1900034	regulation of cellular response to heat
BP	IMP	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle
MF	IDA	GO:0001030	RNA polymerase III type 1 promoter DNA binding
MF	IDA	GO:0001031	RNA polymerase III type 2 promoter DNA binding
MF	IDA	GO:0001032	RNA polymerase III type 3 promoter DNA binding
MF	IDA	GO:0001156	TFIIIC-class transcription factor binding
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0019901	protein kinase binding
MF	IDA	GO:0030291	protein serine/threonine kinase inhibitor activity
MF	IDA	GO:0030295	protein kinase activator activity
MF	IBA	GO:0030674	protein binding, bridging
MF	IDA	GO:0030674	protein binding, bridging
MF	IPI	GO:0044877	protein-containing complex binding
MF	IDA	GO:0071889	14-3-3 protein binding

Gene expression in normal tissue: RPTOR

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RPTOR

Database	Pathway ID	Pathway Des.
kegg	hsa04136	Autophagy - other - Homo sapiens (human)
kegg	hsa04140	Autophagy - animal - Homo sapiens (human)
kegg	hsa04150	mTOR signaling pathway - Homo sapiens (human)
kegg	hsa04151	PI3K-Akt signaling pathway - Homo sapiens (human)
kegg	hsa04152	AMPK signaling pathway - Homo sapiens (human)
kegg	hsa04211	Longevity regulating pathway - Homo sapiens (human)
kegg	hsa04213	Longevity regulating pathway - multiple species - Homo sapiens (human)
kegg	hsa04714	Thermogenesis - Homo sapiens (human)
kegg	hsa04910	Insulin signaling pathway - Homo sapiens (human)
kegg	hsa05206	MicroRNAs in cancer - Homo sapiens (human)
pid	lkb1_pathway	LKB1 signaling events
pid	met_pathway	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pid	mtor_4pathway	mTOR signaling pathway
wikipathways	WP1403	AMP-activated Protein Kinase (AMPK) Signaling
wikipathways	WP1471	Target Of Rapamycin (TOR) Signaling
wikipathways	WP3844	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
wikipathways	WP3915	Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways	WP3932	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways	WP4011	Steatosis AOP
wikipathways	WP4018	Pathways in clear cell renal cell carcinoma
wikipathways	WP4172	PI3K-Akt Signaling Pathway
wikipathways	WP585	Interferon type I signaling pathways
reactome	R-HSA-1257604	PIP3 activates AKT signaling
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1632852	Macroautophagy
reactome	R-HSA-165159	mTOR signalling
reactome	R-HSA-166208	mTORC1-mediated signalling
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-2262752	Cellular responses to stress
reactome	R-HSA-3371556	Cellular response to heat stress
reactome	R-HSA-3371571	HSF1-dependent transactivation
reactome	R-HSA-3700989	Transcriptional Regulation by TP53
reactome	R-HSA-380972	Energy dependent regulation of mTOR by LKB1-AMPK
reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
reactome	R-HSA-6807070	PTEN Regulation
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-8943724	Regulation of PTEN gene transcription
reactome	R-HSA-8953897	Cellular responses to external stimuli
reactome	R-HSA-9006925	Intracellular signaling by second messengers

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD366	PI-103	6
iGMDRD329	Merck60	5
iGMDRD286	Nsc 632839	2
iGMDRD263	AACOCF3	3
iGMDRD552	AZD-1775	3
iGMDRD300	Tozasertib	6
iGMDRD505	Pevonedistat	6
iGMDRD5	Tyrphostin AG 1478	3
iGMDRD202	Curcumin	3
iGMDRD415	LE-135	2
iGMDRD481	Dactolisib	6
iGMDRD434	BMS-536924	3
iGMDRD289	Parthenolide	3
iGMDRD105	Triptolide	1
iGMDRD698	Neratinib	3
iGMDRD177	Teniposide	2
iGMDRD211	(1S,3R)-RSL3	2
iGMDRD512	nutlin 3	2
iGMDRD584	VER 155008	3
iGMDRD486	Tosedostat	3
iGMDRD84	Lovastatin acid	1
iGMDRD345	Compound 10b [PMID: 11504634]	4
iGMDRD424	Tamatinib	3
iGMDRD150	RITA	3
iGMDRD562	Navitoclax	3
iGMDRD577	BIX01294	5
iGMDRD188	Piperlongumine	5
iGMDRD60	Quinoclamine	2
iGMDRD802	4-methylfasudil	1
iGMDRD474	Avrainvillamide	3
iGMDRD870	BRD63610	2
iGMDRD171	Pemetrexed	2
iGMDRD782	DC-45-A2	3
iGMDRD152	179324-69-7	2
iGMDRD634	SCHEMBL2608041	4
iGMDRD375	GW-405833	2
iGMDRD679	Bistramide A	1
iGMDRD280	CYTOCHALASIN B	10
iGMDRD466	Chaetocin	2
iGMDRD394	BX-795	3
iGMDRD781	Sirolimus	3
iGMDRD670	ML 210	2
iGMDRD144	NSC95397	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPTOR

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DATATYPES

CLASSFICATION

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