TNK2


Summary: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008].

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GO terms in TNK2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0006897 endocytosis
BP TAS GO:0007166 cell surface receptor signaling pathway
BP IBA GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
BP TAS GO:0007264 small GTPase mediated signal transduction
BP IDA GO:0016310 phosphorylation
BP IBA GO:0030154 cell differentiation
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Gene expression in normal tissue: TNK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined40Leukocyte transendothelial migration1One carbon pool by folate1Apoptosis regulation1ERK MAPK signaling1Proteasome1DNA replication1Protein stability and degradation1Cell cycle1Chromatin histone acetylation1

Pathways in TNK2


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Database
Pathway ID
Pathway Des.
wikipathways WP306 Focal Adhesion
wikipathways WP3941 Oxidative Damage
wikipathways WP437 EGF-EGFR Signaling Pathway
wikipathways WP524 G13 Signaling Pathway
pid cdc42_pathway CDC42 signaling events
netpath Pathway_EGFR1 EGFR1
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD405 PIK-75 2
iGMDRD345 Compound 10b [PMID: 11504634] 2
iGMDRD512 nutlin 3 2
iGMDRD123 Isoevodiamine 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNK2

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Model
Level
Reference ID
Tissue
Cancer
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Clinical Response
Source
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