TNK2
Summary: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
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OMIM IDMIM:606994 Ensembl IDEnsembl:ENSG00000061938 HGNC IDHGNC:HGNC:19297 PHARMGKB IDPA134909759 Map Location3q29 |
GO terms in TNK2
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IEA | GO:0006897 | endocytosis |
BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
BP | IBA | GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
BP | TAS | GO:0007264 | small GTPase mediated signal transduction |
BP | IDA | GO:0016310 | phosphorylation |
BP | IBA | GO:0030154 | cell differentiation |
Gene expression in normal tissue: TNK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TNK2
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP306 | Focal Adhesion |
wikipathways | WP3941 | Oxidative Damage |
wikipathways | WP437 | EGF-EGFR Signaling Pathway |
wikipathways | WP524 | G13 Signaling Pathway |
pid | cdc42_pathway | CDC42 signaling events |
netpath | Pathway_EGFR1 | EGFR1 |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in TNK2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |