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TNK2

Summary: This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
tyrosine kinase non receptor 2	MIM:606994	Ensembl:ENSG00000061938	HGNC:HGNC:19297	PA134909759	3q29

Gene Categories:

DRUGGABLE GENOME TYROSINE KINASE SERINE THREONINE KINASE KINASE

GO terms in TNK2

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0006897	endocytosis
BP	TAS	GO:0007166	cell surface receptor signaling pathway
BP	IBA	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
BP	TAS	GO:0007264	small GTPase mediated signal transduction
BP	IDA	GO:0016310	phosphorylation
BP	IBA	GO:0030154	cell differentiation
BP	IEA	GO:0034260	negative regulation of GTPase activity
BP	IBA	GO:0038083	peptidyl-tyrosine autophosphorylation
BP	IBA	GO:0042127	regulation of cell proliferation
BP	IBA	GO:0045087	innate immune response
BP	IDA	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
BP	IDA	GO:2000369	regulation of clathrin-dependent endocytosis
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005737	cytoplasm
CC	ISS	GO:0005768	endosome
CC	IDA	GO:0005886	plasma membrane
CC	IDA	GO:0005905	clathrin-coated pit
CC	IEA	GO:0005912	adherens junction
CC	HDA	GO:0016020	membrane
CC	IDA	GO:0030136	clathrin-coated vesicle
CC	IEA	GO:0030659	cytoplasmic vesicle membrane
CC	IBA	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
CC	IEA	GO:0048471	perinuclear region of cytoplasm
CC	IDA	GO:0070436	Grb2-EGFR complex
MF	IEA	GO:0004674	protein serine/threonine kinase activity
MF	IDA	GO:0004712	protein serine/threonine/tyrosine kinase activity
MF	IDA	GO:0004713	protein tyrosine kinase activity
MF	IBA	GO:0004715	non-membrane spanning protein tyrosine kinase activity
MF	TAS	GO:0005095	GTPase inhibitor activity
MF	IBA	GO:0005102	signaling receptor binding
MF	IDA	GO:0005154	epidermal growth factor receptor binding
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IPI	GO:0031625	ubiquitin protein ligase binding
MF	IPI	GO:0042802	identical protein binding
MF	IEA	GO:0046872	metal ion binding
MF	ISS	GO:0050699	WW domain binding

Gene expression in normal tissue: TNK2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TNK2

Database	Pathway ID	Pathway Des.
wikipathways	WP306	Focal Adhesion
wikipathways	WP3941	Oxidative Damage
wikipathways	WP437	EGF-EGFR Signaling Pathway
wikipathways	WP524	G13 Signaling Pathway
pid	cdc42_pathway	CDC42 signaling events
netpath	Pathway_EGFR1	EGFR1

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD405	PIK-75	2
iGMDRD345	Compound 10b [PMID: 11504634]	2
iGMDRD512	nutlin 3	2
iGMDRD123	Isoevodiamine	2
iGMDRD237	ABT-751	5
iGMDRD314	Tanespimycin	2
iGMDRD57	Chloropentafluorobenzene	3
iGMDRD351	GW843682X	4
iGMDRD415	LE-135	2
iGMDRD289	Parthenolide	2
iGMDRD6	AM-580	1
iGMDRD105	Triptolide	2
iGMDRD5	Tyrphostin AG 1478	2
iGMDRD137	Indisulam	12
iGMDRD202	Curcumin	4
iGMDRD103	SN-38	5
iGMDRD82	Quiflapon	1
iGMDRD246	NPC26	2
iGMDRD505	Pevonedistat	3
iGMDRD483	SCH-529074	1
iGMDRD494	Neopeltolide	2
iGMDRD1008	SR-II-138A	3
iGMDRD772	BRD4770	2
iGMDRD425	ERASTIN	2
iGMDRD634	SCHEMBL2608041	2
iGMDRD375	GW-405833	1
iGMDRD679	Bistramide A	2
iGMDRD394	BX-795	1
iGMDRD280	CYTOCHALASIN B	1
iGMDRD466	Chaetocin	3
iGMDRD2	PK-11195	2
iGMDRD152	179324-69-7	2
iGMDRD193	Fqi1	4
iGMDRD316	N9-Isopropyl-olomoucine	1
iGMDRD446	LY 2183240	1
iGMDRD294	Batimastat	2
iGMDRD870	BRD63610	2
iGMDRD171	Pemetrexed	6
iGMDRD802	4-methylfasudil	2
iGMDRD474	Avrainvillamide	2
iGMDRD513	BML-259	2
iGMDRD524	ISX-9	5
iGMDRD356	PNU-74654	2
iGMDRD60	Quinoclamine	3
iGMDRD64	Parbendazole	4
iGMDRD562	Navitoclax	2
iGMDRD887	Compound 23 citrate	2
iGMDRD399	Selumetinib	3
iGMDRD74	Idarubicin	5
iGMDRD188	Piperlongumine	5
iGMDRD100	Zebularine	4

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNK2

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.