BIRC3
Summary: This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| baculoviral IAP repeat containing 3 | MIM:601721 | Ensembl:ENSG00000023445 | HGNC:HGNC:591 | PA25360 | 11q22.2 |
GO terms in BIRC3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | EXP | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IDA | GO:0004842 | ubiquitin-protein transferase activity |
| MF | TAS | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | EXP | GO:0016740 | transferase activity |
| MF | IBA | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IBA | GO:0061630 | ubiquitin protein ligase activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0032991 | protein-containing complex |
| CC | IEA | GO:0045121 | membrane raft |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | TAS | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IDA | GO:0031398 | positive regulation of protein ubiquitination |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | TAS | GO:0034121 | regulation of toll-like receptor signaling pathway |
| BP | TAS | GO:0038061 | NIK/NF-kappaB signaling |
| BP | TAS | GO:0039535 | regulation of RIG-I signaling pathway |
| BP | IMP | GO:0042981 | regulation of apoptotic process |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | TAS | GO:0045088 | regulation of innate immune response |
| BP | TAS | GO:0050727 | regulation of inflammatory response |
| BP | IEA | GO:0051291 | protein heterooligomerization |
| BP | IMP | GO:0060544 | regulation of necroptotic process |
| BP | TAS | GO:0060544 | regulation of necroptotic process |
| BP | IBA | GO:0060546 | negative regulation of necroptotic process |
| BP | TAS | GO:0070424 | regulation of nucleotide-binding oligomerization domain containing signaling pathway |
| BP | IBA | GO:0090307 | mitotic spindle assembly |
| BP | IBA | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:2000116 | regulation of cysteine-type endopeptidase activity |
Gene expression in normal tissue: BIRC3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BIRC3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | cd40_pathway | CD40/CD40L signaling |
| pid | ceramide_pathway | Ceramide signaling pathway |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | faspathway | FAS (CD95) signaling pathway |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | tnfpathway | TNF receptor signaling pathway |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04120 | Ubiquitin mediated proteolysis - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2036 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2880 | Glucocorticoid Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168638 | NOD1/2 Signaling Pathway |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5213460 | RIPK1-mediated regulated necrosis |
| reactome | R-HSA-5218859 | Regulated Necrosis |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5357905 | Regulation of TNFR1 signaling |
| reactome | R-HSA-5357956 | TNFR1-induced NFkappaB signaling pathway |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5675482 | Regulation of necroptotic cell death |
| reactome | R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75893 | TNF signaling |
| reactome | R-HSA-937041 | IKK complex recruitment mediated by RIP1 |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | ceramidepathway | ceramide signaling pathway |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | mitochondriapathway | role of mitochondria in apoptotic signaling |
| biocarta | soddpathway | sodd/tnfr1 signaling pathway |
| biocarta | tnfr1pathway | tnfr1 signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD121 | GMX1778 | 6 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD134 | Sorafenib | 2 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD318 | PAC-1 | 7 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD210 | AC55649 | 3 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD607 | Ubistatin B | 3 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD494 | Neopeltolide | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BIRC3
CLASSFICATION
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