BIRC3

Summary: This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namebaculoviral IAP repeat containing 3
OMIM IDMIM:601721
Ensembl IDEnsembl:ENSG00000023445
HGNC IDHGNC:HGNC:591
PHARMGKB IDPA25360
Map Location11q22.2

GO terms in BIRC3


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Term Type
Evidence Type
GO Term ID
GO Des.
MF EXP GO:0004842 ubiquitin-protein transferase activity
MF IDA GO:0004842 ubiquitin-protein transferase activity
MF TAS GO:0004842 ubiquitin-protein transferase activity
MF IPI GO:0005515 protein binding
MF EXP GO:0016740 transferase activity
MF IBA GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
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Gene expression in normal tissue: BIRC3

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 27undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 29BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 9

Gene-drug pathway distribution

undefined9Apoptosis regulation2Proteasome1Leukocyte transendothelial migration1Purine metabolism1Chromatin histone acetylation1Stilbenoid, diarylheptanoid and gingerol biosynthesis1Metabolism1ERK MAPK signaling1VEGF signaling pathway1

Pathways in BIRC3


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Database
Pathway ID
Pathway Des.
pid caspase_pathway Caspase Cascade in Apoptosis
pid cd40_pathway CD40/CD40L signaling
pid ceramide_pathway Ceramide signaling pathway
pid cmyb_pathway C-MYB transcription factor network
pid faspathway FAS (CD95) signaling pathway
pid hivnefpathway HIV-1 Nef: Negative effector of Fas and TNF-alpha
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD399 Selumetinib 3
iGMDRD398 Sepantronium 3
iGMDRD322 FK 866 3
iGMDRD474 Avrainvillamide 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BIRC3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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