TFEB
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transcription factor EB | MIM:600744 | Ensembl:ENSG00000112561 | HGNC:HGNC:11753 | PA36468 | 6p21.1 |
GO terms in TFEB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | NAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IEA | GO:0046983 | protein dimerization activity |
| CC | IDA | GO:0005634 | nucleus |
| CC | NAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| BP | ISS | GO:0001892 | embryonic placenta development |
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | NAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006914 | autophagy |
| BP | ISS | GO:0006959 | humoral immune response |
| BP | IMP | GO:0007040 | lysosome organization |
| BP | IMP | GO:0010508 | positive regulation of autophagy |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Gene expression in normal tissue: TFEB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TFEB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04137 | Mitophagy - animal - Homo sapiens (human) |
| wikipathways | WP3844 | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |
| wikipathways | WP4241 | Type 2 papillary renal cell carcinoma |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD126 | Tipifarnib | 7 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD351 | GW843682X | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TFEB
CLASSFICATION
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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.