MYLK3
Summary: Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| myosin light chain kinase 3 | MIM:612147 | Ensembl:ENSG00000140795 | HGNC:HGNC:29826 | PA162396375 | 16q11.2 |
GO terms in MYLK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0004683 | calmodulin-dependent protein kinase activity |
| MF | IBA | GO:0004687 | myosin light chain kinase activity |
| MF | ISS | GO:0004687 | myosin light chain kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| BP | IMP | GO:0002528 | regulation of vascular permeability involved in acute inflammatory response |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0045214 | sarcomere organization |
| BP | ISS | GO:0045214 | sarcomere organization |
| BP | ISS | GO:0048769 | sarcomerogenesis |
| BP | IBA | GO:0055003 | cardiac myofibril assembly |
| BP | ISS | GO:0055003 | cardiac myofibril assembly |
| BP | ISS | GO:0060298 | positive regulation of sarcomere organization |
| BP | IMP | GO:0071347 | cellular response to interleukin-1 |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005829 | cytosol |
| CC | IBA | GO:0015629 | actin cytoskeleton |
| CC | IEA | GO:0015629 | actin cytoskeleton |
Gene expression in normal tissue: MYLK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MYLK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP2406 | Cardiac Progenitor Differentiation |
| wikipathways | WP306 | Focal Adhesion |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04971 | Gastric acid secretion - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD562 | Navitoclax | 8 |
| iGMDRD506 | Fedratinib | 9 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD60 | Quinoclamine | 6 |
| iGMDRD886 | Compound 1541A | 6 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD434 | BMS-536924 | 7 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD231 | Importazole | 2 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD152 | 179324-69-7 | 5 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD718 | Pyrvinium pamoate | 4 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD150 | RITA | 6 |
| iGMDRD781 | Sirolimus | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MYLK3
CLASSFICATION
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