MYLK3


Summary: Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in MYLK3


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISS GO:0004683 calmodulin-dependent protein kinase activity
MF IBA GO:0004687 myosin light chain kinase activity
MF ISS GO:0004687 myosin light chain kinase activity
MF IEA GO:0005524 ATP binding
BP IMP GO:0002528 regulation of vascular permeability involved in acute inflammatory response
BP ISS GO:0006468 protein phosphorylation
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Gene expression in normal tissue: MYLK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined19Apoptosis regulation2Protein stability and degradation1Longevity regulating pathway1Cell cycle1Other, kinases1ERK MAPK signaling1Proteasome1

Pathways in MYLK3


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Database
Pathway ID
Pathway Des.
wikipathways WP1544 MicroRNAs in cardiomyocyte hypertrophy
wikipathways WP2406 Cardiac Progenitor Differentiation
wikipathways WP306 Focal Adhesion
kegg hsa04020 Calcium signaling pathway - Homo sapiens (human)
kegg hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
kegg hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD399 Selumetinib 1
iGMDRD100 Zebularine 2
iGMDRD188 Piperlongumine 2
iGMDRD562 Navitoclax 8
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MYLK3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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