MYLK3
Summary: Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:612147 Ensembl IDEnsembl:ENSG00000140795 HGNC IDHGNC:HGNC:29826 PHARMGKB IDPA162396375 Map Location16q11.2 | |||||
GO terms in MYLK3
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0004683 | calmodulin-dependent protein kinase activity |
| MF | IBA | GO:0004687 | myosin light chain kinase activity |
| MF | ISS | GO:0004687 | myosin light chain kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| BP | IMP | GO:0002528 | regulation of vascular permeability involved in acute inflammatory response |
| BP | ISS | GO:0006468 | protein phosphorylation |
Gene expression in normal tissue: MYLK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MYLK3
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP2406 | Cardiac Progenitor Differentiation |
| wikipathways | WP306 | Focal Adhesion |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MYLK3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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