SUZ12
Summary: This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606245 Ensembl IDEnsembl:ENSG00000178691 HGNC IDHGNC:HGNC:17101 PHARMGKB IDPA134936035 Map Location17q11.2 | |||||
GO terms in SUZ12
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0031490 | chromatin DNA binding |
| MF | IDA | GO:0035064 | methylated histone binding |
| MF | IBA | GO:0042054 | histone methyltransferase activity |
Gene expression in normal tissue: SUZ12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SUZ12
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2916 | Interactome of polycomb repressive complex 2 (PRC2) |
| wikipathways | WP3404 | Oxidative Stress Induced Senescence |
| wikipathways | WP4204 | Tumor suppressor activity of SMARCB1 |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SUZ12
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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