SUZ12
Summary: This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| SUZ12, polycomb repressive complex 2 subunit | MIM:606245 | Ensembl:ENSG00000178691 | HGNC:HGNC:17101 | PA134936035 | 17q11.2 |
GO terms in SUZ12
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0031490 | chromatin DNA binding |
| MF | IDA | GO:0035064 | methylated histone binding |
| MF | IBA | GO:0042054 | histone methyltransferase activity |
| MF | IMP | GO:0042054 | histone methyltransferase activity |
| MF | IMP | GO:0042054 | histone methyltransferase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IMP | GO:0046976 | histone methyltransferase activity (H3-K27 specific) |
| MF | IEA | GO:1990841 | promoter-specific chromatin binding |
| CC | IEA | GO:0001739 | sex chromatin |
| CC | HDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IBA | GO:0016586 | RSC-type complex |
| CC | IDA | GO:0016604 | nuclear body |
| CC | IEA | GO:0032993 | protein-DNA complex |
| CC | IBA | GO:0035098 | ESC/E(Z) complex |
| CC | IDA | GO:0035098 | ESC/E(Z) complex |
| CC | IMP | GO:0035098 | ESC/E(Z) complex |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0016574 | histone ubiquitination |
| BP | IMP | GO:0045596 | negative regulation of cell differentiation |
| BP | TAS | GO:0045814 | negative regulation of gene expression, epigenetic |
| BP | TAS | GO:0070317 | negative regulation of G0 to G1 transition |
| BP | IEA | GO:0070734 | histone H3-K27 methylation |
Gene expression in normal tissue: SUZ12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SUZ12
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2916 | Interactome of polycomb repressive complex 2 (PRC2) |
| wikipathways | WP3404 | Oxidative Stress Induced Senescence |
| wikipathways | WP4204 | Tumor suppressor activity of SMARCB1 |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-212165 | Epigenetic regulation of gene expression |
| reactome | R-HSA-212300 | PRC2 methylates histones and DNA |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3214841 | PKMTs methylate histone lysines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4551638 | SUMOylation of chromatin organization proteins |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8953750 | Transcriptional Regulation by E2F6 |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| biocarta | prc2pathway | the prc2 complex sets long-term gene silencing through modification of histone tails |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD105 | Triptolide | 6 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD835 | BET inhibitor | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD562 | Navitoclax | 9 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD483 | SCH-529074 | 6 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD351 | GW843682X | 5 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD341 | Triacsin c | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SUZ12
CLASSFICATION
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