SUZ12


Summary: This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SUZ12, polycomb repressive complex 2 subunitMIM:606245Ensembl:ENSG00000178691HGNC:HGNC:17101PA13493603517q11.2

GO terms in SUZ12


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIBAGO:0031490chromatin DNA binding
MFIDAGO:0035064methylated histone binding
MFIBAGO:0042054histone methyltransferase activity
MFIMPGO:0042054histone methyltransferase activity
MFIMPGO:0042054histone methyltransferase activity
MFIEAGO:0046872metal ion binding
MFIMPGO:0046976histone methyltransferase activity (H3-K27 specific)
MFIEAGO:1990841promoter-specific chromatin binding
CCIEAGO:0001739sex chromatin
CCHDAGO:0005634nucleus
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIBAGO:0016586RSC-type complex
CCIDAGO:0016604nuclear body
CCIEAGO:0032993protein-DNA complex
CCIBAGO:0035098ESC/E(Z) complex
CCIDAGO:0035098ESC/E(Z) complex
CCIMPGO:0035098ESC/E(Z) complex
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006351transcription, DNA-templated
BPIBAGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0008284positive regulation of cell proliferation
BPIEAGO:0016574histone ubiquitination
BPIMPGO:0045596negative regulation of cell differentiation
BPTASGO:0045814negative regulation of gene expression, epigenetic
BPTASGO:0070317negative regulation of G0 to G1 transition
BPIEAGO:0070734histone H3-K27 methylation

Gene expression in normal tissue: SUZ12

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SUZ12


DatabasePathway IDPathway Des.
wikipathwaysWP2916Interactome of polycomb repressive complex 2 (PRC2)
wikipathwaysWP3404Oxidative Stress Induced Senescence
wikipathwaysWP4204Tumor suppressor activity of SMARCB1
wikipathwaysWP4239EMT transition in Colorectal Cancer
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-212165Epigenetic regulation of gene expression
reactomeR-HSA-212300PRC2 methylates histones and DNA
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3214841PKMTs methylate histone lysines
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-4551638SUMOylation of chromatin organization proteins
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesis
reactomeR-HSA-5619507Activation of HOX genes during differentiation
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6807070PTEN Regulation
reactomeR-HSA-6807070PTEN Regulation
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8943724Regulation of PTEN gene transcription
reactomeR-HSA-8943724Regulation of PTEN gene transcription
reactomeR-HSA-8953750Transcriptional Regulation by E2F6
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006925Intracellular signaling by second messengers
biocartaprc2pathwaythe prc2 complex sets long-term gene silencing through modification of histone tails

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD105Triptolide6
iGMDRD255SB2250023
iGMDRD270Ciclosporin3
iGMDRD474Avrainvillamide1
iGMDRD835BET inhibitor3
iGMDRD506Fedratinib3
iGMDRD577BIX012946
iGMDRD780PP-301
iGMDRD562Navitoclax9
iGMDRD887Compound 23 citrate2
iGMDRD523Cyanoquinoline, 113
iGMDRD483SCH-5290746
iGMDRD781Sirolimus5
iGMDRD779PRL-3 Inhibitor I3
iGMDRD427ABT7373
iGMDRD126Tipifarnib4
iGMDRD351GW843682X5
iGMDRD61Kinetin riboside4
iGMDRD341Triacsin c1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SUZ12

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