DGKG
Summary: This gene encodes an enzyme that is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| diacylglycerol kinase gamma | MIM:601854 | Ensembl:ENSG00000058866 | HGNC:HGNC:2853 | PA27314 | 3q27.2-q27.3 |
Gene Categories:
KINASEGO terms in DGKG
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0030168 | platelet activation |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0046486 | glycerolipid metabolic process |
| BP | IDA | GO:0046834 | lipid phosphorylation |
| BP | IEA | GO:0048666 | neuron development |
| MF | IEA | GO:0003951 | NAD+ kinase activity |
| MF | IDA | GO:0004143 | diacylglycerol kinase activity |
| MF | TAS | GO:0004143 | diacylglycerol kinase activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: DGKG
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DGKG
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00561 | Glycerolipid metabolism - Homo sapiens (human) |
| kegg | hsa00564 | Glycerophospholipid metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114508 | Effects of PIP2 hydrolysis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD330 | BRD4132 | 6 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD341 | Triacsin c | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD271 | Brefeldin A | 4 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD420 | Leucascandrolide A | 1 |
| iGMDRD1008 | SR-II-138A | 5 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD546 | BMS-754807 | 5 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD359 | OSW-1 | 2 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD474 | Avrainvillamide | 1 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD524 | ISX-9 | 5 |
| iGMDRD451 | Serdemetan | 1 |
| iGMDRD23 | Gossypol | 5 |
| iGMDRD356 | PNU-74654 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DGKG
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