MFSD2A
Summary: The protein encoded by this gene is a transmembrane protein and sodium-dependent lysophosphatidylcholine transporter. The encoded protein is involved in the establishment of the blood-brain barrier and is required for brain growth and function. Defects in this gene are a cause of a progressive microcephaly syndrome. [provided by RefSeq, Mar 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| major facilitator superfamily domain containing 2A | MIM:614397 | Ensembl:ENSG00000168389 | HGNC:HGNC:25897 | PA165751549 | 1p34.2 |
GO terms in MFSD2A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0005887 | integral component of plasma membrane |
| BP | TAS | GO:0006656 | phosphatidylcholine biosynthetic process |
| BP | ISS | GO:0015908 | fatty acid transport |
| BP | ISS | GO:0021766 | hippocampus development |
| BP | ISS | GO:0045056 | transcytosis |
| BP | IDA | GO:0051977 | lysophospholipid transport |
| BP | IEA | GO:0055085 | transmembrane transport |
| BP | ISS | GO:0060856 | establishment of blood-brain barrier |
| BP | ISS | GO:1990379 | lipid transport across blood brain barrier |
| MF | ISS | GO:0005548 | phospholipid transporter activity |
| MF | TAS | GO:0005548 | phospholipid transporter activity |
| MF | ISS | GO:0015245 | fatty acid transmembrane transporter activity |
| MF | ISS | GO:0015293 | symporter activity |
| MF | IDA | GO:0051978 | lysophospholipid transporter activity |
Gene expression in normal tissue: MFSD2A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MFSD2A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483191 | Synthesis of PC |
| reactome | R-HSA-1483206 | Glycerophospholipid biosynthesis |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 3 |
| iGMDRD474 | Avrainvillamide | 5 |
| iGMDRD138 | PX 12 | 5 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD885 | Compound 110 | 5 |
| iGMDRD782 | DC-45-A2 | 4 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD188 | Piperlongumine | 10 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD268 | Cerulenin | 5 |
| iGMDRD1008 | SR-II-138A | 10 |
| iGMDRD772 | BRD4770 | 5 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD889 | Compound 7d-cis | 10 |
| iGMDRD427 | ABT737 | 8 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD144 | NSC95397 | 9 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD201 | SKI II | 10 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 6 |
| iGMDRD280 | CYTOCHALASIN B | 15 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD213 | SMR000068650 | 6 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD289 | Parthenolide | 8 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD82 | Quiflapon | 10 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD300 | Tozasertib | 5 |
| iGMDRD148 | Pifithrin-mu | 5 |
| iGMDRD584 | VER 155008 | 3 |
| iGMDRD307 | Manumycin A | 9 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD511 | CHEMBL399379 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MFSD2A
CLASSFICATION
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