MFSD2A


Summary: The protein encoded by this gene is a transmembrane protein and sodium-dependent lysophosphatidylcholine transporter. The encoded protein is involved in the establishment of the blood-brain barrier and is required for brain growth and function. Defects in this gene are a cause of a progressive microcephaly syndrome. [provided by RefSeq, Mar 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
major facilitator superfamily domain containing 2AMIM:614397Ensembl:ENSG00000168389HGNC:HGNC:25897PA1657515491p34.2

GO terms in MFSD2A


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005789endoplasmic reticulum membrane
CCTASGO:0005886plasma membrane
CCISSGO:0005887integral component of plasma membrane
BPTASGO:0006656phosphatidylcholine biosynthetic process
BPISSGO:0015908fatty acid transport
BPISSGO:0021766hippocampus development
BPISSGO:0045056transcytosis
BPIDAGO:0051977lysophospholipid transport
BPIEAGO:0055085transmembrane transport
BPISSGO:0060856establishment of blood-brain barrier
BPISSGO:1990379lipid transport across blood brain barrier
MFISSGO:0005548phospholipid transporter activity
MFTASGO:0005548phospholipid transporter activity
MFISSGO:0015245fatty acid transmembrane transporter activity
MFISSGO:0015293symporter activity
MFIDAGO:0051978lysophospholipid transporter activity

Gene expression in normal tissue: MFSD2A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MFSD2A


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483191Synthesis of PC
reactomeR-HSA-1483206Glycerophospholipid biosynthesis
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-556833Metabolism of lipids

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD255SB2250023
iGMDRD474Avrainvillamide5
iGMDRD138PX 125
iGMDRD226ML0063
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD885Compound 1105
iGMDRD782DC-45-A24
iGMDRD562Navitoclax6
iGMDRD577BIX012945
iGMDRD188Piperlongumine10
iGMDRD524ISX-93
iGMDRD268Cerulenin5
iGMDRD1008SR-II-138A10
iGMDRD772BRD47705
iGMDRD599Salermide2
iGMDRD889Compound 7d-cis10
iGMDRD427ABT7378
iGMDRD546BMS-7548072
iGMDRD144NSC953979
iGMDRD152179324-69-71
iGMDRD201SKI II10
iGMDRD446LY 21832403
iGMDRD634SCHEMBL26080416
iGMDRD280CYTOCHALASIN B15
iGMDRD158NSC1415402
iGMDRD213SMR0000686506
iGMDRD105Triptolide1
iGMDRD289Parthenolide8
iGMDRD286Nsc 6328393
iGMDRD322FK 8663
iGMDRD82Quiflapon10
iGMDRD353PD03259011
iGMDRD300Tozasertib5
iGMDRD148Pifithrin-mu5
iGMDRD584VER 1550083
iGMDRD307Manumycin A9
iGMDRD330BRD41322
iGMDRD523Cyanoquinoline, 112
iGMDRD351GW843682X3
iGMDRD698Neratinib3
iGMDRD85Ursolic acid3
iGMDRD154NSC237662
iGMDRD945ML2146
iGMDRD511CHEMBL3993792

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MFSD2A

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