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PINK1

Summary: This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NamePTEN induced putative kinase 1 OMIM IDMIM:608309 Ensembl IDEnsembl:ENSG00000158828 HGNC IDHGNC:HGNC:14581 PHARMGKB IDPA33325 Map Location1p36.12

Gene Categories:

PROTEASE KINASE SERINE THREONINE KINASE DRUGGABLE GENOME HISTONE MODIFICATION

GO terms in PINK1

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0000422	autophagy of mitochondrion
BP	IMP	GO:0000422	autophagy of mitochondrion
BP	IDA	GO:0001934	positive regulation of protein phosphorylation
BP	IDA	GO:0002082	regulation of oxidative phosphorylation
BP	IEA	GO:0002931	response to ischemia
BP	IBA	GO:0006468	protein phosphorylation

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Gene expression in normal tissue: PINK1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PINK1

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-5205647	Mitophagy
reactome	R-HSA-5205685	Pink/Parkin Mediated Mitophagy
kegg	hsa04137	Mitophagy - animal - Homo sapiens (human)
kegg	hsa05012	Parkinson,s disease - Homo sapiens (human)
wikipathways	WP2371	Parkinsons Disease Pathway

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD121	GMX1778	4
iGMDRD474	Avrainvillamide	3
iGMDRD512	nutlin 3	1
iGMDRD780	PP-30	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PINK1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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