PINK1
Summary: This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| PTEN induced putative kinase 1 | MIM:608309 | Ensembl:ENSG00000158828 | HGNC:HGNC:14581 | PA33325 | 1p36.12 |
GO terms in PINK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000422 | autophagy of mitochondrion |
| BP | IMP | GO:0000422 | autophagy of mitochondrion |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IDA | GO:0002082 | regulation of oxidative phosphorylation |
| BP | IEA | GO:0002931 | response to ischemia |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006511 | ubiquitin-dependent protein catabolic process |
| BP | IGI | GO:0006979 | response to oxidative stress |
| BP | IMP | GO:0007005 | mitochondrion organization |
| BP | IEA | GO:0010310 | regulation of hydrogen peroxide metabolic process |
| BP | ISS | GO:0010629 | negative regulation of gene expression |
| BP | IMP | GO:0010821 | regulation of mitochondrion organization |
| BP | TAS | GO:0010952 | positive regulation of peptidase activity |
| BP | TAS | GO:0016236 | macroautophagy |
| BP | IMP | GO:0016239 | positive regulation of macroautophagy |
| BP | IMP | GO:0016242 | negative regulation of macroautophagy |
| BP | IMP | GO:0016567 | protein ubiquitination |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | ISS | GO:0018105 | peptidyl-serine phosphorylation |
| BP | TAS | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IEA | GO:0022904 | respiratory electron transport chain |
| BP | IDA | GO:0031396 | regulation of protein ubiquitination |
| BP | IMP | GO:0031396 | regulation of protein ubiquitination |
| BP | ISS | GO:0031398 | positive regulation of protein ubiquitination |
| BP | IC | GO:0032148 | activation of protein kinase B activity |
| BP | IEA | GO:0032226 | positive regulation of synaptic transmission, dopaminergic |
| BP | IDA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IMP | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | TAS | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IEA | GO:0033603 | positive regulation of dopamine secretion |
| BP | IMP | GO:0034599 | cellular response to oxidative stress |
| BP | IEA | GO:0035307 | positive regulation of protein dephosphorylation |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | IMP | GO:0036289 | peptidyl-serine autophosphorylation |
| BP | TAS | GO:0036289 | peptidyl-serine autophosphorylation |
| BP | IC | GO:0038203 | TORC2 signaling |
| BP | IBA | GO:0042981 | regulation of apoptotic process |
| BP | IDA | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0043254 | regulation of protein complex assembly |
| BP | IMP | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IEA | GO:0045727 | positive regulation of translation |
| BP | TAS | GO:0046329 | negative regulation of JNK cascade |
| BP | IMP | GO:0050821 | protein stabilization |
| BP | IEA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | TAS | GO:0051443 | positive regulation of ubiquitin-protein transferase activity |
| BP | IGI | GO:0051881 | regulation of mitochondrial membrane potential |
| BP | IMP | GO:0051881 | regulation of mitochondrial membrane potential |
| BP | IC | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | NAS | GO:0061136 | regulation of proteasomal protein catabolic process |
| BP | IMP | GO:0071456 | cellular response to hypoxia |
| BP | IMP | GO:0072655 | establishment of protein localization to mitochondrion |
| BP | IMP | GO:0072656 | maintenance of protein location in mitochondrion |
| BP | IBA | GO:0090141 | positive regulation of mitochondrial fission |
| BP | IMP | GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
| BP | IMP | GO:0090258 | negative regulation of mitochondrial fission |
| BP | TAS | GO:0097237 | cellular response to toxic substance |
| BP | IMP | GO:0098779 | positive regulation of mitophagy in response to mitochondrial depolarization |
| BP | IMP | GO:0099074 | mitochondrion to lysosome transport |
| BP | IMP | GO:1900407 | regulation of cellular response to oxidative stress |
| BP | IEA | GO:1901727 | positive regulation of histone deacetylase activity |
| BP | TAS | GO:1902803 | regulation of synaptic vesicle transport |
| BP | IMP | GO:1902902 | negative regulation of autophagosome assembly |
| BP | TAS | GO:1902958 | positive regulation of mitochondrial electron transport, NADH to ubiquinone |
| BP | TAS | GO:1903146 | regulation of autophagy of mitochondrion |
| BP | IMP | GO:1903147 | negative regulation of autophagy of mitochondrion |
| BP | IDA | GO:1903202 | negative regulation of oxidative stress-induced cell death |
| BP | TAS | GO:1903204 | negative regulation of oxidative stress-induced neuron death |
| BP | IDA | GO:1903214 | regulation of protein targeting to mitochondrion |
| BP | IGI | GO:1903214 | regulation of protein targeting to mitochondrion |
| BP | IMP | GO:1903214 | regulation of protein targeting to mitochondrion |
| BP | IEA | GO:1903298 | negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway |
| BP | IDA | GO:1903384 | negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway |
| BP | IMP | GO:1903384 | negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway |
| BP | IDA | GO:1903751 | negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide |
| BP | IMP | GO:1903852 | positive regulation of cristae formation |
| BP | HMP | GO:1903955 | positive regulation of protein targeting to mitochondrion |
| BP | ISS | GO:1904544 | positive regulation of free ubiquitin chain polymerization |
| BP | IEA | GO:1904783 | positive regulation of NMDA glutamate receptor activity |
| BP | IEA | GO:1904881 | cellular response to hydrogen sulfide |
| BP | IGI | GO:2000377 | regulation of reactive oxygen species metabolic process |
| BP | IMP | GO:2000377 | regulation of reactive oxygen species metabolic process |
| BP | IMP | GO:2000378 | negative regulation of reactive oxygen species metabolic process |
| BP | TAS | GO:2001171 | positive regulation of ATP biosynthetic process |
| BP | IDA | GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway |
| CC | ISS | GO:0000151 | ubiquitin ligase complex |
| CC | IDA | GO:0000785 | chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IGI | GO:0005739 | mitochondrion |
| CC | IMP | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005741 | mitochondrial outer membrane |
| CC | IMP | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005741 | mitochondrial outer membrane |
| CC | IMP | GO:0005742 | mitochondrial outer membrane translocase complex |
| CC | IDA | GO:0005743 | mitochondrial inner membrane |
| CC | IDA | GO:0005758 | mitochondrial intermembrane space |
| CC | TAS | GO:0005758 | mitochondrial intermembrane space |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005856 | cytoskeleton |
| CC | IDA | GO:0016020 | membrane |
| CC | IDA | GO:0030424 | axon |
| CC | IEA | GO:0030426 | growth cone |
| CC | IDA | GO:0031307 | integral component of mitochondrial outer membrane |
| CC | IPI | GO:0031932 | TORC2 complex |
| CC | IDA | GO:0044297 | cell body |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | TAS | GO:0097413 | Lewy body |
| CC | IDA | GO:0097449 | astrocyte projection |
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IPI | GO:0002020 | protease binding |
| MF | TAS | GO:0002020 | protease binding |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | IMP | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IDA | GO:0010857 | calcium-dependent protein kinase activity |
| MF | IDA | GO:0016301 | kinase activity |
| MF | NAS | GO:0016301 | kinase activity |
| MF | TAS | GO:0016504 | peptidase activator activity |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IDA | GO:0043422 | protein kinase B binding |
| MF | IPI | GO:0055131 | C3HC4-type RING finger domain binding |
Gene expression in normal tissue: PINK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PINK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-5205647 | Mitophagy |
| reactome | R-HSA-5205685 | Pink/Parkin Mediated Mitophagy |
| kegg | hsa04137 | Mitophagy - animal - Homo sapiens (human) |
| kegg | hsa05012 | Parkinson,s disease - Homo sapiens (human) |
| wikipathways | WP2371 | Parkinsons Disease Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD154 | NSC23766 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PINK1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.