PPP1R3A
Summary: The glycogen-associated form of protein phosphatase-1 (PP1) derived from skeletal muscle is a heterodimer composed of a 37-kD catalytic subunit and a 124-kD targeting and regulatory subunit. This gene encodes the regulatory subunit which binds to muscle glycogen with high affinity, thereby enhancing dephosphorylation of glycogen-bound substrates for PP1 such as glycogen synthase and glycogen phosphorylase kinase. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein phosphatase 1 regulatory subunit 3A | MIM:600917 | Ensembl:ENSG00000154415 | HGNC:HGNC:9291 | PA33651 | 7q31.1 |
GO terms in PPP1R3A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0005977 | glycogen metabolic process |
| CC | IEA | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: PPP1R3A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PPP1R3A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP481 | Insulin Signaling |
| pid | insulin_glucose_pathway | Insulin-mediated glucose transport |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD359 | OSW-1 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD61 | Kinetin riboside | 8 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD779 | PRL-3 Inhibitor I | 2 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD369 | TGX-115 | 1 |
| iGMDRD398 | Sepantronium | 4 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD870 | BRD63610 | 4 |
| iGMDRD318 | PAC-1 | 6 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD474 | Avrainvillamide | 5 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD499 | PDMP | 2 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 5 |
| iGMDRD49 | Mitomycin | 2 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD116 | CD437 | 6 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD202 | Curcumin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PPP1R3A
CLASSFICATION
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