SOX11


Summary: This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SRY-box 11MIM:600898Ensembl:ENSG00000176887HGNC:HGNC:11191PA360282p25.2

Gene Categories:

TUMOR SUPPRESSOR

GO terms in SOX11


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000122negative regulation of transcription by RNA polymerase II
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPISSGO:0001501skeletal system development
BPIBAGO:0001654eye development
BPIEAGO:0001822kidney development
BPISSGO:0001841neural tube formation
BPISSGO:0002089lens morphogenesis in camera-type eye
BPISSGO:0003151outflow tract morphogenesis
BPISSGO:0003211cardiac ventricle formation
BPISSGO:0003357noradrenergic neuron differentiation
BPIBAGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006366transcription by RNA polymerase II
BPIEAGO:0006412translation
BPISSGO:0008284positive regulation of cell proliferation
BPIBAGO:0009653anatomical structure morphogenesis
BPIMPGO:0010628positive regulation of gene expression
BPIMPGO:0010629negative regulation of gene expression
BPIEAGO:0014003oligodendrocyte development
BPISSGO:0014009glial cell proliferation
BPISSGO:0014032neural crest cell development
BPIEPGO:0017015regulation of transforming growth factor beta receptor signaling pathway
BPISSGO:0021510spinal cord development
BPISSGO:0021782glial cell development
BPIBAGO:0030154cell differentiation
BPIBAGO:0030182neuron differentiation
BPIEPGO:0030182neuron differentiation
BPISSGO:0030513positive regulation of BMP signaling pathway
BPISSGO:0035332positive regulation of hippo signaling
BPIEAGO:0035914skeletal muscle cell differentiation
BPIMPGO:0045666positive regulation of neuron differentiation
BPIMPGO:0045669positive regulation of osteoblast differentiation
BPIMPGO:0045778positive regulation of ossification
BPISSGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0046887positive regulation of hormone secretion
BPISSGO:0048485sympathetic nervous system development
BPISSGO:0048557embryonic digestive tract morphogenesis
BPISSGO:0048704embryonic skeletal system morphogenesis
BPIMPGO:0050672negative regulation of lymphocyte proliferation
BPISSGO:0050769positive regulation of neurogenesis
BPISSGO:0060022hard palate development
BPISSGO:0060023soft palate development
BPISSGO:0060174limb bud formation
BPIMPGO:0060253negative regulation of glial cell proliferation
BPISSGO:0060412ventricular septum morphogenesis
BPISSGO:0060425lung morphogenesis
BPISSGO:0060548negative regulation of cell death
BPISSGO:0060563neuroepithelial cell differentiation
BPISSGO:0061029eyelid development in camera-type eye
BPISSGO:0061053somite development
BPISSGO:0061303cornea development in camera-type eye
BPISSGO:0061386closure of optic fissure
BPIEPGO:0072395signal transduction involved in cell cycle checkpoint
BPIMPGO:2000648positive regulation of stem cell proliferation
BPISSGO:2000678negative regulation of transcription regulatory region DNA binding
BPISSGO:2001111positive regulation of lens epithelial cell proliferation
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCIBAGO:0044798nuclear transcription factor complex
MFISSGO:0000976transcription regulatory region sequence-specific DNA binding
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFISSGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIDAGO:0001158enhancer sequence-specific DNA binding
MFISSGO:0003700DNA-binding transcription factor activity
MFISSGO:0003713transcription coactivator activity
MFIDAGO:0008135translation factor activity, RNA binding

Gene expression in normal tissue: SOX11

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SOX11


DatabasePathway IDPathway Des.
wikipathwaysWP3527Preimplantation Embryo

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD8012,4-dideoxy-DC-45-A26
iGMDRD318PAC-16
iGMDRD294Batimastat1
iGMDRD513BML-2593
iGMDRD247Blebbistatin6
iGMDRD474Avrainvillamide3
iGMDRD8024-methylfasudil6
iGMDRD255SB2250021
iGMDRD690PRIMA-1MET6
iGMDRD60Quinoclamine6
iGMDRD268Cerulenin6
iGMDRD23Gossypol3
iGMDRD451Serdemetan3
iGMDRD188Piperlongumine3
iGMDRD74Idarubicin1
iGMDRD577BIX012946
iGMDRD224Necrostatin-13
iGMDRD506Fedratinib3
iGMDRD888Compound 443
iGMDRD144NSC953971
iGMDRD427ABT7373
iGMDRD126Tipifarnib3
iGMDRD772BRD47706
iGMDRD579PF7503
iGMDRD634SCHEMBL26080416
iGMDRD375GW-4058333
iGMDRD380Pifithrin-alpha6
iGMDRD446LY 21832403
iGMDRD201SKI II3
iGMDRD434BMS-5369243
iGMDRD213SMR0000686506
iGMDRD300Tozasertib3
iGMDRD147Prima-13
iGMDRD353PD03259012
iGMDRD82Quiflapon3
iGMDRD871BRD63686
iGMDRD872BRD71373
iGMDRD329Merck606
iGMDRD150RITA1
iGMDRD701NVP-AUY9223
iGMDRD307Manumycin A3
iGMDRD607Ubistatin B6
iGMDRD148Pifithrin-mu6
iGMDRD219Bax channel blocker3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SOX11

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