GPR119

Summary: This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameG protein-coupled receptor 119
OMIM IDMIM:300513
Ensembl IDEnsembl:ENSG00000147262
HGNC IDHGNC:HGNC:19060
PHARMGKB IDPA134928131
Map LocationXq26.1

GO terms in GPR119


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0004930 G-protein coupled receptor activity
MF IEA GO:0031210 phosphatidylcholine binding
CC IEA GO:0005886 plasma membrane
CC IEA GO:0016021 integral component of membrane
CC IDA GO:0043235 receptor complex
BP IEA GO:0007186 G-protein coupled receptor signaling pathway
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Gene expression in normal tissue: GPR119

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 11undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 17

Gene-drug pathway distribution

Pathways in GPR119


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Database
Pathway ID
Pathway Des.
kegg hsa04024 cAMP signaling pathway - Homo sapiens (human)
kegg hsa04911 Insulin secretion - Homo sapiens (human)
reactome R-HSA-2980736 Peptide hormone metabolism
reactome R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-400508 Incretin synthesis, secretion, and inactivation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD434 BMS-536924 2
iGMDRD474 Avrainvillamide 5
iGMDRD126 Tipifarnib 3
iGMDRD60 Quinoclamine 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GPR119

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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