GPR119
Summary: This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| G protein-coupled receptor 119 | MIM:300513 | Ensembl:ENSG00000147262 | HGNC:HGNC:19060 | PA134928131 | Xq26.1 |
GO terms in GPR119
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004930 | G-protein coupled receptor activity |
| MF | IEA | GO:0031210 | phosphatidylcholine binding |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0043235 | receptor complex |
| BP | IEA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0030073 | insulin secretion |
Gene expression in normal tissue: GPR119
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GPR119
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| reactome | R-HSA-2980736 | Peptide hormone metabolism |
| reactome | R-HSA-381771 | Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-400508 | Incretin synthesis, secretion, and inactivation |
| reactome | R-HSA-400511 | Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD474 | Avrainvillamide | 5 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD60 | Quinoclamine | 1 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD23 | Gossypol | 4 |
| iGMDRD871 | BRD6368 | 5 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD506 | Fedratinib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GPR119
CLASSFICATION
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