GPR119


Summary: This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
G protein-coupled receptor 119MIM:300513Ensembl:ENSG00000147262HGNC:HGNC:19060PA134928131Xq26.1

GO terms in GPR119


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0004930G-protein coupled receptor activity
MFIEAGO:0031210phosphatidylcholine binding
CCIEAGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCIDAGO:0043235receptor complex
BPIEAGO:0007186G-protein coupled receptor signaling pathway
BPIEAGO:0030073insulin secretion

Gene expression in normal tissue: GPR119

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GPR119


DatabasePathway IDPathway Des.
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
reactomeR-HSA-2980736Peptide hormone metabolism
reactomeR-HSA-381771Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-400508Incretin synthesis, secretion, and inactivation
reactomeR-HSA-400511Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD434BMS-5369242
iGMDRD474Avrainvillamide5
iGMDRD126Tipifarnib3
iGMDRD60Quinoclamine1
iGMDRD505Pevonedistat2
iGMDRD23Gossypol4
iGMDRD871BRD63685
iGMDRD398Sepantronium3
iGMDRD506Fedratinib3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GPR119

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