DLC1


Summary: This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

Gene Categories:

PROTEASE

GO terms in DLC1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005634 nucleus
CC IDA GO:0005737 cytoplasm
CC IDA GO:0005829 cytosol
CC TAS GO:0005829 cytosol
CC IDA GO:0005901 caveola
CC IDA GO:0005925 focal adhesion
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Gene expression in normal tissue: DLC1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined39Cell cycle2Apoptosis regulation2Longevity regulating pathway1Terpenoid backbone biosynthesis1p53 pathway1One carbon pool by folate1Th17 cell differentiation1Chromatin histone acetylation1DNA replication1

Pathways in DLC1


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Database
Pathway ID
Pathway Des.
pid rhoa_reg_pathway Regulation of RhoA activity
biocarta plcdpathway phospholipase c delta in phospholipid associated cell signaling
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-194315 Signaling by Rho GTPases
reactome R-HSA-194840 Rho GTPase cycle
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD237 ABT-751 1
iGMDRD351 GW843682X 1
iGMDRD314 Tanespimycin 7
iGMDRD85 Ursolic acid 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DLC1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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