DLC1
Summary: This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
DLC1 Rho GTPase activating protein | MIM:604258 | Ensembl:ENSG00000164741 | HGNC:HGNC:2897 | PA27351 | 8p22 |
Gene Categories:
PROTEASEGO terms in DLC1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IDA | GO:0005634 | nucleus |
CC | IDA | GO:0005737 | cytoplasm |
CC | IDA | GO:0005829 | cytosol |
CC | TAS | GO:0005829 | cytosol |
CC | IDA | GO:0005901 | caveola |
CC | IDA | GO:0005925 | focal adhesion |
CC | IDA | GO:0030864 | cortical actin cytoskeleton |
CC | IDA | GO:0032587 | ruffle membrane |
BP | ISS | GO:0001843 | neural tube closure |
BP | ISS | GO:0003007 | heart morphogenesis |
BP | IDA | GO:0006915 | apoptotic process |
BP | IDA | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
BP | IEA | GO:0007165 | signal transduction |
BP | IDA | GO:0008285 | negative regulation of cell proliferation |
BP | IMP | GO:0008285 | negative regulation of cell proliferation |
BP | IMP | GO:0008360 | regulation of cell shape |
BP | ISS | GO:0021575 | hindbrain morphogenesis |
BP | ISS | GO:0030036 | actin cytoskeleton organization |
BP | IDA | GO:0030336 | negative regulation of cell migration |
BP | IMP | GO:0030336 | negative regulation of cell migration |
BP | ISS | GO:0030900 | forebrain development |
BP | IMP | GO:0032956 | regulation of actin cytoskeleton organization |
BP | IMP | GO:0035024 | negative regulation of Rho protein signal transduction |
BP | IDA | GO:0035307 | positive regulation of protein dephosphorylation |
BP | IEA | GO:0043547 | positive regulation of GTPase activity |
BP | ISS | GO:0048041 | focal adhesion assembly |
BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
BP | IDA | GO:0051497 | negative regulation of stress fiber assembly |
BP | IDA | GO:0051895 | negative regulation of focal adhesion assembly |
BP | IDA | GO:1900119 | positive regulation of execution phase of apoptosis |
MF | IDA | GO:0005096 | GTPase activator activity |
MF | IDA | GO:0005096 | GTPase activator activity |
MF | IMP | GO:0005096 | GTPase activator activity |
MF | TAS | GO:0005096 | GTPase activator activity |
MF | IPI | GO:0005515 | protein binding |
MF | IEA | GO:0008289 | lipid binding |
MF | IPI | GO:0042169 | SH2 domain binding |
Gene expression in normal tissue: DLC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DLC1
Database | Pathway ID | Pathway Des. |
---|---|---|
pid | rhoa_reg_pathway | Regulation of RhoA activity |
biocarta | plcdpathway | phospholipase c delta in phospholipid associated cell signaling |
reactome | R-HSA-162582 | Signal Transduction |
reactome | R-HSA-194315 | Signaling by Rho GTPases |
reactome | R-HSA-194840 | Rho GTPase cycle |
Gene-Drug: Aster Plot
Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD237 | ABT-751 | 1 |
iGMDRD351 | GW843682X | 1 |
iGMDRD314 | Tanespimycin | 7 |
iGMDRD85 | Ursolic acid | 1 |
iGMDRD154 | NSC23766 | 2 |
iGMDRD435 | BI-2536 | 3 |
iGMDRD945 | ML214 | 2 |
iGMDRD123 | Isoevodiamine | 2 |
iGMDRD211 | (1S,3R)-RSL3 | 1 |
iGMDRD901 | ELCPK | 2 |
iGMDRD148 | Pifithrin-mu | 3 |
iGMDRD307 | Manumycin A | 2 |
iGMDRD79 | Gemcitabine | 2 |
iGMDRD522 | ML-030 | 2 |
iGMDRD116 | CD437 | 1 |
iGMDRD532 | Olaparib | 2 |
iGMDRD150 | RITA | 1 |
iGMDRD329 | Merck60 | 1 |
iGMDRD662 | JQ-1 | 1 |
iGMDRD872 | BRD7137 | 2 |
iGMDRD246 | NPC26 | 2 |
iGMDRD552 | AZD-1775 | 5 |
iGMDRD300 | Tozasertib | 3 |
iGMDRD137 | Indisulam | 1 |
iGMDRD158 | NSC141540 | 7 |
iGMDRD202 | Curcumin | 3 |
iGMDRD434 | BMS-536924 | 1 |
iGMDRD289 | Parthenolide | 2 |
iGMDRD193 | Fqi1 | 3 |
iGMDRD359 | OSW-1 | 3 |
iGMDRD280 | CYTOCHALASIN B | 3 |
iGMDRD394 | BX-795 | 3 |
iGMDRD679 | Bistramide A | 2 |
iGMDRD1008 | SR-II-138A | 2 |
iGMDRD599 | Salermide | 4 |
iGMDRD151 | CHM-1 | 4 |
iGMDRD126 | Tipifarnib | 6 |
iGMDRD76 | Simvastatin | 2 |
iGMDRD781 | Sirolimus | 1 |
iGMDRD779 | PRL-3 Inhibitor I | 1 |
iGMDRD427 | ABT737 | 5 |
iGMDRD562 | Navitoclax | 2 |
iGMDRD74 | Idarubicin | 3 |
iGMDRD100 | Zebularine | 1 |
iGMDRD188 | Piperlongumine | 1 |
iGMDRD451 | Serdemetan | 3 |
iGMDRD64 | Parbendazole | 3 |
iGMDRD60 | Quinoclamine | 2 |
iGMDRD690 | PRIMA-1MET | 3 |
iGMDRD260 | FQI-2 | 1 |
iGMDRD138 | PX 12 | 5 |
iGMDRD474 | Avrainvillamide | 2 |
iGMDRD270 | Ciclosporin | 1 |
iGMDRD187 | BRD9876 | 4 |
iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
iGMDRD318 | PAC-1 | 4 |
iGMDRD171 | Pemetrexed | 4 |
Gene in drug-gene network: Network Plot
![](image/gene_network_legends.png)
Gene-drug targets distribution
Gene Structure: PDB
Models in DLC1