DLC1
Summary: This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| DLC1 Rho GTPase activating protein | MIM:604258 | Ensembl:ENSG00000164741 | HGNC:HGNC:2897 | PA27351 | 8p22 |
Gene Categories:
PROTEASEGO terms in DLC1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005901 | caveola |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0030864 | cortical actin cytoskeleton |
| CC | IDA | GO:0032587 | ruffle membrane |
| BP | ISS | GO:0001843 | neural tube closure |
| BP | ISS | GO:0003007 | heart morphogenesis |
| BP | IDA | GO:0006915 | apoptotic process |
| BP | IDA | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | IMP | GO:0008285 | negative regulation of cell proliferation |
| BP | IMP | GO:0008360 | regulation of cell shape |
| BP | ISS | GO:0021575 | hindbrain morphogenesis |
| BP | ISS | GO:0030036 | actin cytoskeleton organization |
| BP | IDA | GO:0030336 | negative regulation of cell migration |
| BP | IMP | GO:0030336 | negative regulation of cell migration |
| BP | ISS | GO:0030900 | forebrain development |
| BP | IMP | GO:0032956 | regulation of actin cytoskeleton organization |
| BP | IMP | GO:0035024 | negative regulation of Rho protein signal transduction |
| BP | IDA | GO:0035307 | positive regulation of protein dephosphorylation |
| BP | IEA | GO:0043547 | positive regulation of GTPase activity |
| BP | ISS | GO:0048041 | focal adhesion assembly |
| BP | TAS | GO:0051056 | regulation of small GTPase mediated signal transduction |
| BP | IDA | GO:0051497 | negative regulation of stress fiber assembly |
| BP | IDA | GO:0051895 | negative regulation of focal adhesion assembly |
| BP | IDA | GO:1900119 | positive regulation of execution phase of apoptosis |
| MF | IDA | GO:0005096 | GTPase activator activity |
| MF | IDA | GO:0005096 | GTPase activator activity |
| MF | IMP | GO:0005096 | GTPase activator activity |
| MF | TAS | GO:0005096 | GTPase activator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008289 | lipid binding |
| MF | IPI | GO:0042169 | SH2 domain binding |
Gene expression in normal tissue: DLC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DLC1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | rhoa_reg_pathway | Regulation of RhoA activity |
| biocarta | plcdpathway | phospholipase c delta in phospholipid associated cell signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD314 | Tanespimycin | 7 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 1 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD522 | ML-030 | 2 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD150 | RITA | 1 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD662 | JQ-1 | 1 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD552 | AZD-1775 | 5 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD158 | NSC141540 | 7 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD359 | OSW-1 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD599 | Salermide | 4 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD126 | Tipifarnib | 6 |
| iGMDRD76 | Simvastatin | 2 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD690 | PRIMA-1MET | 3 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD138 | PX 12 | 5 |
| iGMDRD474 | Avrainvillamide | 2 |
| iGMDRD270 | Ciclosporin | 1 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD171 | Pemetrexed | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DLC1
CLASSFICATION
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