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TRIP11

Summary: This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
thyroid hormone receptor interactor 11	MIM:604505	Ensembl:ENSG00000100815	HGNC:HGNC:12305	PA36984	14q32.12

GO terms in TRIP11

Term Type	Evidence Type	GO Term ID	GO Des.
CC	TAS	GO:0000139	Golgi membrane
CC	IEA	GO:0002079	inner acrosomal membrane
CC	IEA	GO:0002081	outer acrosomal membrane
CC	IDA	GO:0005634	nucleus
CC	IDA	GO:0005794	Golgi apparatus
CC	IEA	GO:0005801	cis-Golgi network
CC	IEA	GO:0005856	cytoskeleton
CC	IEA	GO:0005929	cilium
CC	IDA	GO:0016607	nuclear speck
CC	TAS	GO:0030133	transport vesicle
BP	IEA	GO:0003281	ventricular septum development
BP	IEA	GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis
BP	TAS	GO:0006366	transcription by RNA polymerase II
BP	IEA	GO:0006486	protein glycosylation
BP	IEA	GO:0007030	Golgi organization
BP	TAS	GO:0035735	intraciliary transport involved in cilium assembly
BP	IEA	GO:0060122	inner ear receptor cell stereocilium organization
BP	IEA	GO:1903508	positive regulation of nucleic acid-templated transcription
MF	TAS	GO:0003713	transcription coactivator activity
MF	IPI	GO:0005515	protein binding

Gene expression in normal tissue: TRIP11

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TRIP11

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1852241	Organelle biogenesis and maintenance
reactome	R-HSA-199991	Membrane Trafficking
reactome	R-HSA-5617833	Cilium Assembly
reactome	R-HSA-5620924	Intraflagellar transport
reactome	R-HSA-5653656	Vesicle-mediated transport
reactome	R-HSA-6811438	Intra-Golgi traffic
reactome	R-HSA-6811442	Intra-Golgi and retrograde Golgi-to-ER traffic

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD190	Nilotinib	1
iGMDRD64	Parbendazole	6
iGMDRD524	ISX-9	2
iGMDRD356	PNU-74654	2
iGMDRD100	Zebularine	2
iGMDRD188	Piperlongumine	2
iGMDRD562	Navitoclax	6
iGMDRD187	BRD9876	3
iGMDRD318	PAC-1	1
iGMDRD474	Avrainvillamide	1
iGMDRD260	FQI-2	2
iGMDRD802	4-methylfasudil	6
iGMDRD280	CYTOCHALASIN B	2
iGMDRD466	Chaetocin	3
iGMDRD634	SCHEMBL2608041	2
iGMDRD446	LY 2183240	4
iGMDRD61	Kinetin riboside	2
iGMDRD193	Fqi1	4
iGMDRD718	Pyrvinium pamoate	1
iGMDRD427	ABT737	1
iGMDRD483	SCH-529074	3
iGMDRD494	Neopeltolide	3
iGMDRD151	CHM-1	3
iGMDRD1008	SR-II-138A	2
iGMDRD889	Compound 7d-cis	3
iGMDRD552	AZD-1775	2
iGMDRD505	Pevonedistat	7
iGMDRD871	BRD6368	2
iGMDRD414	MST-312	3
iGMDRD329	Merck60	2
iGMDRD434	BMS-536924	3
iGMDRD705	Nakiterpiosin	2
iGMDRD77	Itraconazole	4
iGMDRD415	LE-135	2
iGMDRD137	Indisulam	7
iGMDRD158	NSC141540	1
iGMDRD121	GMX1778	2
iGMDRD202	Curcumin	1
iGMDRD227	Fatostatin A	6
iGMDRD177	Teniposide	4
iGMDRD123	Isoevodiamine	5
iGMDRD237	ABT-751	3
iGMDRD351	GW843682X	3
iGMDRD314	Tanespimycin	2
iGMDRD345	Compound 10b [PMID: 11504634]	6
iGMDRD150	RITA	5
iGMDRD79	Gemcitabine	4
iGMDRD405	PIK-75	6
iGMDRD512	nutlin 3	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRIP11

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.