TRIP11

Summary: This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namethyroid hormone receptor interactor 11
OMIM IDMIM:604505
Ensembl IDEnsembl:ENSG00000100815
HGNC IDHGNC:HGNC:12305
PHARMGKB IDPA36984
Map Location14q32.12

GO terms in TRIP11


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0000139 Golgi membrane
CC IEA GO:0002079 inner acrosomal membrane
CC IEA GO:0002081 outer acrosomal membrane
CC IDA GO:0005634 nucleus
CC IDA GO:0005794 Golgi apparatus
CC IEA GO:0005801 cis-Golgi network
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Gene expression in normal tissue: TRIP11

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined41Apoptosis regulation2Protein stability and degradation1Purine metabolism1Cell cycle1DNA replication1ABL signaling1Stilbenoid, diarylheptanoid and gingerol biosynthesis1

Pathways in TRIP11


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1852241 Organelle biogenesis and maintenance
reactome R-HSA-199991 Membrane Trafficking
reactome R-HSA-5617833 Cilium Assembly
reactome R-HSA-5620924 Intraflagellar transport
reactome R-HSA-5653656 Vesicle-mediated transport
reactome R-HSA-6811438 Intra-Golgi traffic
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD190 Nilotinib 1
iGMDRD64 Parbendazole 6
iGMDRD524 ISX-9 2
iGMDRD356 PNU-74654 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRIP11

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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