RORA


Summary: The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in RORA


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IMP GO:0001525 angiogenesis
BP IDA GO:0006355 regulation of transcription, DNA-templated
BP TAS GO:0006367 transcription initiation from RNA polymerase II promoter
BP ISS GO:0006805 xenobiotic metabolic process
BP IEA GO:0006809 nitric oxide biosynthetic process
BP ISS GO:0008589 regulation of smoothened signaling pathway
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Gene expression in normal tissue: RORA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined75Apoptosis regulation2ERK MAPK signaling2Protein stability and degradation2Cell cycle2Biosynthesis of secondary metabolites1Mitosis1RTK signaling1p53 pathway1Other, kinases1

Pathways in RORA


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Database
Pathway ID
Pathway Des.
pid hif1_tfpathway HIF-1-alpha transcription factor network
kegg hsa04659 Th17 cell differentiation - Homo sapiens (human)
kegg hsa04710 Circadian rhythm - Homo sapiens (human)
kegg hsa05321 Inflammatory bowel disease (IBD) - Homo sapiens (human)
wikipathways WP170 Nuclear Receptors
wikipathways WP1797 Circadian Clock
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD405 PIK-75 5
iGMDRD79 Gemcitabine 4
iGMDRD522 ML-030 2
iGMDRD150 RITA 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RORA

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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