RORA


Summary: The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
RAR related orphan receptor AMIM:600825Ensembl:ENSG00000069667HGNC:HGNC:10258PA3463015q22.2

GO terms in RORA


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0001525angiogenesis
BPIDAGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006367transcription initiation from RNA polymerase II promoter
BPISSGO:0006805xenobiotic metabolic process
BPIEAGO:0006809nitric oxide biosynthetic process
BPISSGO:0008589regulation of smoothened signaling pathway
BPIMPGO:0010575positive regulation of vascular endothelial growth factor production
BPISSGO:0010906regulation of glucose metabolic process
BPISSGO:0019218regulation of steroid metabolic process
BPTASGO:0019221cytokine-mediated signaling pathway
BPIEAGO:0021702cerebellar Purkinje cell differentiation
BPISSGO:0021930cerebellar granule cell precursor proliferation
BPIDAGO:0030522intracellular receptor signaling pathway
BPISSGO:0032922circadian regulation of gene expression
BPIDAGO:0036315cellular response to sterol
BPIMPGO:0036315cellular response to sterol
BPISSGO:0042632cholesterol homeostasis
BPIMPGO:0042692muscle cell differentiation
BPISSGO:0042753positive regulation of circadian rhythm
BPIEAGO:0043030regulation of macrophage activation
BPIMPGO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0043401steroid hormone mediated signaling pathway
BPISSGO:0045599negative regulation of fat cell differentiation
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0046068cGMP metabolic process
BPIBAGO:0050728negative regulation of inflammatory response
BPIMPGO:0050728negative regulation of inflammatory response
BPISSGO:0060850regulation of transcription involved in cell fate commitment
BPIMPGO:0070328triglyceride homeostasis
BPIEAGO:0071347cellular response to interleukin-1
BPIEAGO:0071356cellular response to tumor necrosis factor
BPIMPGO:0071456cellular response to hypoxia
BPISSGO:0072539T-helper 17 cell differentiation
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
MFIDAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIPIGO:0001222transcription corepressor binding
MFIBAGO:0001223transcription coactivator binding
MFIPIGO:0001223transcription coactivator binding
MFICGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIDAGO:0003677DNA binding
MFIDAGO:0003700DNA-binding transcription factor activity
MFIEAGO:0003707steroid hormone receptor activity
MFIEAGO:0004879nuclear receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0008013beta-catenin binding
MFIPIGO:0008134transcription factor binding
MFIBAGO:0008142oxysterol binding
MFIDAGO:0008142oxysterol binding
MFIEAGO:0008270zinc ion binding
MFIDAGO:0043565sequence-specific DNA binding
MFIDAGO:0098531transcription factor activity, direct ligand regulated sequence-specific DNA binding

Gene expression in normal tissue: RORA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RORA


DatabasePathway IDPathway Des.
pidhif1_tfpathwayHIF-1-alpha transcription factor network
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04710Circadian rhythm - Homo sapiens (human)
kegghsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)
wikipathwaysWP170Nuclear Receptors
wikipathwaysWP1797Circadian Clock
wikipathwaysWP236Adipogenesis
wikipathwaysWP3355BMAL1-CLOCK,NPAS2 activates circadian gene expression
wikipathwaysWP3893Development and heterogeneity of the ILC family
wikipathwaysWP3946White fat cell differentiation
wikipathwaysWP4066Interleukin-4 and 13 signaling
wikipathwaysWP4149White fat cell differentiation
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1368082RORA activates gene expression
reactomeR-HSA-1368082RORA activates gene expression
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-168256Immune System
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-383280Nuclear Receptor transcription pathway
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-4090294SUMOylation of intracellular receptors
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signaling
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD405PIK-755
iGMDRD79Gemcitabine4
iGMDRD522ML-0302
iGMDRD150RITA6
iGMDRD532Olaparib2
iGMDRD219Bax channel blocker6
iGMDRD237ABT-7513
iGMDRD698Neratinib5
iGMDRD314Tanespimycin5
iGMDRD341Triacsin c2
iGMDRD945ML2145
iGMDRD123Isoevodiamine7
iGMDRD5Tyrphostin AG 14783
iGMDRD158NSC1415402
iGMDRD121GMX17782
iGMDRD202Curcumin3
iGMDRD137Indisulam11
iGMDRD251ML1623
iGMDRD77Itraconazole2
iGMDRD289Parthenolide8
iGMDRD329Merck606
iGMDRD286Nsc 6328397
iGMDRD871BRD63684
iGMDRD367Ro 28-16752
iGMDRD420Leucascandrolide A3
iGMDRD433Lexibulin2
iGMDRD151CHM-15
iGMDRD76Simvastatin3
iGMDRD126Tipifarnib5
iGMDRD781Sirolimus10
iGMDRD483SCH-5290745
iGMDRD427ABT7377
iGMDRD61Kinetin riboside2
iGMDRD639YK 4-2793
iGMDRD466Chaetocin1
iGMDRD394BX-7951
iGMDRD474Avrainvillamide4
iGMDRD513BML-2593
iGMDRD187BRD98767
iGMDRD294Batimastat2
iGMDRD8012,4-dideoxy-DC-45-A25
iGMDRD171Pemetrexed6
iGMDRD780PP-305
iGMDRD224Necrostatin-16
iGMDRD506Fedratinib8
iGMDRD399Selumetinib3
iGMDRD730Kahalalide F2
iGMDRD74Idarubicin4
iGMDRD188Piperlongumine6
iGMDRD524ISX-96
iGMDRD23Gossypol2
iGMDRD64Parbendazole7
iGMDRD148Pifithrin-mu1
iGMDRD512nutlin 32
iGMDRD307Manumycin A2
iGMDRD84Lovastatin acid2
iGMDRD701NVP-AUY9224
iGMDRD345Compound 10b [PMID: 11504634]6
iGMDRD424Tamatinib2
iGMDRD351GW843682X11
iGMDRD85Ursolic acid3
iGMDRD435BI-25362
iGMDRD177Teniposide2
iGMDRD901ELCPK2
iGMDRD267Oligomycin A3
iGMDRD481Dactolisib2
iGMDRD872BRD71372
iGMDRD882CIL415
iGMDRD414MST-3123
iGMDRD353PD03259012
iGMDRD82Quiflapon3
iGMDRD300Tozasertib7
iGMDRD886Compound 1541A2
iGMDRD505Pevonedistat9
iGMDRD772BRD47702
iGMDRD599Salermide1
iGMDRD144NSC953975
iGMDRD193Fqi15
iGMDRD446LY 21832405
iGMDRD380Pifithrin-alpha1
iGMDRD634SCHEMBL26080413
iGMDRD280CYTOCHALASIN B4
iGMDRD8024-methylfasudil5
iGMDRD255SB2250028
iGMDRD138PX 122
iGMDRD298L-6854582
iGMDRD870BRD636105
iGMDRD885Compound 1109
iGMDRD318PAC-17
iGMDRD782DC-45-A22
iGMDRD562Navitoclax2
iGMDRD577BIX012946
iGMDRD100Zebularine4
iGMDRD451Serdemetan3
iGMDRD444Tivantinib2
iGMDRD268Cerulenin3
iGMDRD60Quinoclamine2
iGMDRD690PRIMA-1MET2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RORA

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