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RORA

Summary: The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
RAR related orphan receptor A	MIM:600825	Ensembl:ENSG00000069667	HGNC:HGNC:10258	PA34630	15q22.2

Gene Categories:

DRUGGABLE GENOME NUCLEAR HORMONE RECEPTOR TRANSCRIPTION FACTOR BINDING

GO terms in RORA

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IMP	GO:0001525	angiogenesis
BP	IDA	GO:0006355	regulation of transcription, DNA-templated
BP	TAS	GO:0006367	transcription initiation from RNA polymerase II promoter
BP	ISS	GO:0006805	xenobiotic metabolic process
BP	IEA	GO:0006809	nitric oxide biosynthetic process
BP	ISS	GO:0008589	regulation of smoothened signaling pathway
BP	IMP	GO:0010575	positive regulation of vascular endothelial growth factor production
BP	ISS	GO:0010906	regulation of glucose metabolic process
BP	ISS	GO:0019218	regulation of steroid metabolic process
BP	TAS	GO:0019221	cytokine-mediated signaling pathway
BP	IEA	GO:0021702	cerebellar Purkinje cell differentiation
BP	ISS	GO:0021930	cerebellar granule cell precursor proliferation
BP	IDA	GO:0030522	intracellular receptor signaling pathway
BP	ISS	GO:0032922	circadian regulation of gene expression
BP	IDA	GO:0036315	cellular response to sterol
BP	IMP	GO:0036315	cellular response to sterol
BP	ISS	GO:0042632	cholesterol homeostasis
BP	IMP	GO:0042692	muscle cell differentiation
BP	ISS	GO:0042753	positive regulation of circadian rhythm
BP	IEA	GO:0043030	regulation of macrophage activation
BP	IMP	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
BP	IEA	GO:0043401	steroid hormone mediated signaling pathway
BP	ISS	GO:0045599	negative regulation of fat cell differentiation
BP	IDA	GO:0045893	positive regulation of transcription, DNA-templated
BP	IDA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IEA	GO:0046068	cGMP metabolic process
BP	IBA	GO:0050728	negative regulation of inflammatory response
BP	IMP	GO:0050728	negative regulation of inflammatory response
BP	ISS	GO:0060850	regulation of transcription involved in cell fate commitment
BP	IMP	GO:0070328	triglyceride homeostasis
BP	IEA	GO:0071347	cellular response to interleukin-1
BP	IEA	GO:0071356	cellular response to tumor necrosis factor
BP	IMP	GO:0071456	cellular response to hypoxia
BP	ISS	GO:0072539	T-helper 17 cell differentiation
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
MF	IDA	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
MF	IDA	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IPI	GO:0001222	transcription corepressor binding
MF	IBA	GO:0001223	transcription coactivator binding
MF	IPI	GO:0001223	transcription coactivator binding
MF	IC	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MF	IDA	GO:0003677	DNA binding
MF	IDA	GO:0003700	DNA-binding transcription factor activity
MF	IEA	GO:0003707	steroid hormone receptor activity
MF	IEA	GO:0004879	nuclear receptor activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0008013	beta-catenin binding
MF	IPI	GO:0008134	transcription factor binding
MF	IBA	GO:0008142	oxysterol binding
MF	IDA	GO:0008142	oxysterol binding
MF	IEA	GO:0008270	zinc ion binding
MF	IDA	GO:0043565	sequence-specific DNA binding
MF	IDA	GO:0098531	transcription factor activity, direct ligand regulated sequence-specific DNA binding

Gene expression in normal tissue: RORA

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RORA

Database	Pathway ID	Pathway Des.
pid	hif1_tfpathway	HIF-1-alpha transcription factor network
kegg	hsa04659	Th17 cell differentiation - Homo sapiens (human)
kegg	hsa04710	Circadian rhythm - Homo sapiens (human)
kegg	hsa05321	Inflammatory bowel disease (IBD) - Homo sapiens (human)
wikipathways	WP170	Nuclear Receptors
wikipathways	WP1797	Circadian Clock
wikipathways	WP236	Adipogenesis
wikipathways	WP3355	BMAL1-CLOCK,NPAS2 activates circadian gene expression
wikipathways	WP3893	Development and heterogeneity of the ILC family
wikipathways	WP3946	White fat cell differentiation
wikipathways	WP4066	Interleukin-4 and 13 signaling
wikipathways	WP4149	White fat cell differentiation
wikipathways	WP706	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-1368082	RORA activates gene expression
reactome	R-HSA-1368082	RORA activates gene expression
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-168256	Immune System
reactome	R-HSA-1989781	PPARA activates gene expression
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-2990846	SUMOylation
reactome	R-HSA-3108232	SUMO E3 ligases SUMOylate target proteins
reactome	R-HSA-383280	Nuclear Receptor transcription pathway
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-400206	Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactome	R-HSA-400253	Circadian Clock
reactome	R-HSA-400253	Circadian Clock
reactome	R-HSA-4090294	SUMOylation of intracellular receptors
reactome	R-HSA-449147	Signaling by Interleukins
reactome	R-HSA-556833	Metabolism of lipids
reactome	R-HSA-597592	Post-translational protein modification
reactome	R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD405	PIK-75	5
iGMDRD79	Gemcitabine	4
iGMDRD522	ML-030	2
iGMDRD150	RITA	6
iGMDRD532	Olaparib	2
iGMDRD219	Bax channel blocker	6
iGMDRD237	ABT-751	3
iGMDRD698	Neratinib	5
iGMDRD314	Tanespimycin	5
iGMDRD341	Triacsin c	2
iGMDRD945	ML214	5
iGMDRD123	Isoevodiamine	7
iGMDRD5	Tyrphostin AG 1478	3
iGMDRD158	NSC141540	2
iGMDRD121	GMX1778	2
iGMDRD202	Curcumin	3
iGMDRD137	Indisulam	11
iGMDRD251	ML162	3
iGMDRD77	Itraconazole	2
iGMDRD289	Parthenolide	8
iGMDRD329	Merck60	6
iGMDRD286	Nsc 632839	7
iGMDRD871	BRD6368	4
iGMDRD367	Ro 28-1675	2
iGMDRD420	Leucascandrolide A	3
iGMDRD433	Lexibulin	2
iGMDRD151	CHM-1	5
iGMDRD76	Simvastatin	3
iGMDRD126	Tipifarnib	5
iGMDRD781	Sirolimus	10
iGMDRD483	SCH-529074	5
iGMDRD427	ABT737	7
iGMDRD61	Kinetin riboside	2
iGMDRD639	YK 4-279	3
iGMDRD466	Chaetocin	1
iGMDRD394	BX-795	1
iGMDRD474	Avrainvillamide	4
iGMDRD513	BML-259	3
iGMDRD187	BRD9876	7
iGMDRD294	Batimastat	2
iGMDRD801	2,4-dideoxy-DC-45-A2	5
iGMDRD171	Pemetrexed	6
iGMDRD780	PP-30	5
iGMDRD224	Necrostatin-1	6
iGMDRD506	Fedratinib	8
iGMDRD399	Selumetinib	3
iGMDRD730	Kahalalide F	2
iGMDRD74	Idarubicin	4
iGMDRD188	Piperlongumine	6
iGMDRD524	ISX-9	6
iGMDRD23	Gossypol	2
iGMDRD64	Parbendazole	7
iGMDRD148	Pifithrin-mu	1
iGMDRD512	nutlin 3	2
iGMDRD307	Manumycin A	2
iGMDRD84	Lovastatin acid	2
iGMDRD701	NVP-AUY922	4
iGMDRD345	Compound 10b [PMID: 11504634]	6
iGMDRD424	Tamatinib	2
iGMDRD351	GW843682X	11
iGMDRD85	Ursolic acid	3
iGMDRD435	BI-2536	2
iGMDRD177	Teniposide	2
iGMDRD901	ELCPK	2
iGMDRD267	Oligomycin A	3
iGMDRD481	Dactolisib	2
iGMDRD872	BRD7137	2
iGMDRD882	CIL41	5
iGMDRD414	MST-312	3
iGMDRD353	PD0325901	2
iGMDRD82	Quiflapon	3
iGMDRD300	Tozasertib	7
iGMDRD886	Compound 1541A	2
iGMDRD505	Pevonedistat	9
iGMDRD772	BRD4770	2
iGMDRD599	Salermide	1
iGMDRD144	NSC95397	5
iGMDRD193	Fqi1	5
iGMDRD446	LY 2183240	5
iGMDRD380	Pifithrin-alpha	1
iGMDRD634	SCHEMBL2608041	3
iGMDRD280	CYTOCHALASIN B	4
iGMDRD802	4-methylfasudil	5
iGMDRD255	SB225002	8
iGMDRD138	PX 12	2
iGMDRD298	L-685458	2
iGMDRD870	BRD63610	5
iGMDRD885	Compound 110	9
iGMDRD318	PAC-1	7
iGMDRD782	DC-45-A2	2
iGMDRD562	Navitoclax	2
iGMDRD577	BIX01294	6
iGMDRD100	Zebularine	4
iGMDRD451	Serdemetan	3
iGMDRD444	Tivantinib	2
iGMDRD268	Cerulenin	3
iGMDRD60	Quinoclamine	2
iGMDRD690	PRIMA-1MET	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RORA

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DATATYPES

CLASSFICATION

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