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RALB

Summary: This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
RAS like proto-oncogene B	MIM:179551	Ensembl:ENSG00000144118	HGNC:HGNC:9840	PA34198	2q14.2

Gene Categories:

KINASE SERINE THREONINE KINASE

GO terms in RALB

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0003924	GTPase activity
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0005525	GTP binding
MF	IMP	GO:0005525	GTP binding
MF	IDA	GO:0019003	GDP binding
MF	IPI	GO:0031625	ubiquitin protein ligase binding
MF	IPI	GO:0051117	ATPase binding
CC	IDA	GO:0000145	exocyst
CC	IDA	GO:0005776	autophagosome
CC	IDA	GO:0005886	plasma membrane
CC	IDA	GO:0030496	midbody
CC	HDA	GO:0070062	extracellular exosome
BP	ISS	GO:0001928	regulation of exocyst assembly
BP	IMP	GO:0001934	positive regulation of protein phosphorylation
BP	IEA	GO:0006915	apoptotic process
BP	IEA	GO:0007049	cell cycle
BP	TAS	GO:0007165	signal transduction
BP	IEA	GO:0007265	Ras protein signal transduction
BP	IDA	GO:0009267	cellular response to starvation
BP	IMP	GO:0032091	negative regulation of protein binding
BP	IMP	GO:0032092	positive regulation of protein binding
BP	IEA	GO:0051301	cell division
BP	ISS	GO:0060178	regulation of exocyst localization
BP	IMP	GO:0071360	cellular response to exogenous dsRNA
BP	IMP	GO:0071902	positive regulation of protein serine/threonine kinase activity
BP	IMP	GO:2000786	positive regulation of autophagosome assembly

Gene expression in normal tissue: RALB

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RALB

Database	Pathway ID	Pathway Des.
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-166520	Signaling by NTRKs
reactome	R-HSA-167044	Signalling to RAS
reactome	R-HSA-171007	p38MAPK events
reactome	R-HSA-187037	Signaling by NTRK1 (TRKA)
reactome	R-HSA-187687	Signalling to ERKs
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
wikipathways	WP4216	Chromosomal and microsatellite instability in colorectal cancer
wikipathways	WP4223	Ras Signaling
wikipathways	WP437	EGF-EGFR Signaling Pathway
pid	cxcr4_pathway	CXCR4-mediated signaling events
pid	foxopathway	FoxO family signaling
pid	p38alphabetapathway	Regulation of p38-alpha and p38-beta
kegg	hsa04014	Ras signaling pathway - Homo sapiens (human)
kegg	hsa04015	Rap1 signaling pathway - Homo sapiens (human)
kegg	hsa04072	Phospholipase D signaling pathway - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05210	Colorectal cancer - Homo sapiens (human)
kegg	hsa05212	Pancreatic cancer - Homo sapiens (human)
netpath	Pathway_EGFR1	EGFR1

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD210	AC55649	2
iGMDRD579	PF750	1
iGMDRD427	ABT737	3
iGMDRD61	Kinetin riboside	2
iGMDRD219	Bax channel blocker	2
iGMDRD945	ML214	1
iGMDRD883	CIL55A	1
iGMDRD634	SCHEMBL2608041	2
iGMDRD474	Avrainvillamide	1
iGMDRD513	BML-259	1
iGMDRD187	BRD9876	1
iGMDRD887	Compound 23 citrate	2
iGMDRD100	Zebularine	4
iGMDRD886	Compound 1541A	2
iGMDRD451	Serdemetan	2
iGMDRD353	PD0325901	2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RALB

SITE

DATATYPES

CLASSFICATION

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