RALB


Summary: This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
RAS like proto-oncogene BMIM:179551Ensembl:ENSG00000144118HGNC:HGNC:9840PA341982q14.2

GO terms in RALB


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0003924GTPase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005525GTP binding
MFIMPGO:0005525GTP binding
MFIDAGO:0019003GDP binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIPIGO:0051117ATPase binding
CCIDAGO:0000145exocyst
CCIDAGO:0005776autophagosome
CCIDAGO:0005886plasma membrane
CCIDAGO:0030496midbody
CCHDAGO:0070062extracellular exosome
BPISSGO:0001928regulation of exocyst assembly
BPIMPGO:0001934positive regulation of protein phosphorylation
BPIEAGO:0006915apoptotic process
BPIEAGO:0007049cell cycle
BPTASGO:0007165signal transduction
BPIEAGO:0007265Ras protein signal transduction
BPIDAGO:0009267cellular response to starvation
BPIMPGO:0032091negative regulation of protein binding
BPIMPGO:0032092positive regulation of protein binding
BPIEAGO:0051301cell division
BPISSGO:0060178regulation of exocyst localization
BPIMPGO:0071360cellular response to exogenous dsRNA
BPIMPGO:0071902positive regulation of protein serine/threonine kinase activity
BPIMPGO:2000786positive regulation of autophagosome assembly

Gene expression in normal tissue: RALB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RALB


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-167044Signalling to RAS
reactomeR-HSA-171007p38MAPK events
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP4223Ras Signaling
wikipathwaysWP437EGF-EGFR Signaling Pathway
pidcxcr4_pathwayCXCR4-mediated signaling events
pidfoxopathwayFoxO family signaling
pidp38alphabetapathwayRegulation of p38-alpha and p38-beta
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
netpathPathway_EGFR1EGFR1

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD210AC556492
iGMDRD579PF7501
iGMDRD427ABT7373
iGMDRD61Kinetin riboside2
iGMDRD219Bax channel blocker2
iGMDRD945ML2141
iGMDRD883CIL55A1
iGMDRD634SCHEMBL26080412
iGMDRD474Avrainvillamide1
iGMDRD513BML-2591
iGMDRD187BRD98761
iGMDRD887Compound 23 citrate2
iGMDRD100Zebularine4
iGMDRD886Compound 1541A2
iGMDRD451Serdemetan2
iGMDRD353PD03259012

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RALB

​​​​