DYRK2


Summary: DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008].

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GO terms in DYRK2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0006468 protein phosphorylation
BP IEP GO:0006974 cellular response to DNA damage stimulus
BP IMP GO:0007224 smoothened signaling pathway
BP IEA GO:0018108 peptidyl-tyrosine phosphorylation
BP IDA GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
BP IDA GO:0045725 positive regulation of glycogen biosynthetic process
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Gene expression in normal tissue: DYRK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined25Apoptosis regulation2Biosynthesis of secondary metabolites2Proteasome1Metabolism1Ferroptosis1PI3K/MTOR signaling1

Pathways in DYRK2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-212436 Generic Transcription Pathway
reactome R-HSA-3700989 Transcriptional Regulation by TP53
reactome R-HSA-5633007 Regulation of TP53 Activity
reactome R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
reactome R-HSA-73857 RNA Polymerase II Transcription
reactome R-HSA-74160 Gene expression (Transcription)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD560 MK-2206 3
iGMDRD148 Pifithrin-mu 2
iGMDRD154 NSC23766 1
iGMDRD132 (-)-gallocatechin-3-O-gallate 5
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DYRK2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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